E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research 


Evaluation of analgesic properties of petroleum ether extract of Zingiber officinale

Prasanth Murukesan, Kala Kesavan.

Abstract
Background: Herbal remedies and alternative therapies have been employed in the treatment of pain from time immemorial. Ginger is a widely used spice with a lot of medicinal properties, and it is especially soothing to the gastro-intestinal system. Most of the analgesics used in modern medicine have side effects to either gastro-intestinal tract or nervous system. Ginger has neither. Scientific evaluation of the analgesic properties of Zingiber officinale is needed.

Aim and Objective: The aim of the study was to evaluate the analgesic effect of three doses of orally administered petroleum ether extract of Z. officinale and to compare with morphine. When tested for analgesic activity, to find out the difference in reaction time at various time intervals for each dose of the extract, and their significance.

Materials and Methods: Petroleum ether extract of Z. officinale rhizomes was used. Wistar strain albino rats (150-200 g) and Swiss albino mice (20-25 g) housed under standard laboratory conditions were used. The central analgesic activities of the extract were evaluated by the tail clip method and hot plate method. Statistical analysis was done by one-way analysis of variance to compare the means in the experimental groups.

Results: In tail clip method, pain was mechanically induced pain and the pain threshold was measured in terms of mice’ reaction time in seconds. All doses of the extract of Z. officinale were capable of increasing the reaction time in mice during the various time periods. Maximum analgesic activity was shown by 800 mg/kg of the extract at 90 minutes. In hot plate test, maximum analgesic activity was shown by 800 mg/kg of the extract at 180 min. At 30 and 60 min, 800 mg/kg of the extract was as effective as the standard drug, morphine.

Conclusions: The study revealed that Z. officinale has significant analgesic properties especially in higher doses.

Key words: Zingiber officinale; Hot Plate Test; Tail Clip Test; Analgesic


 
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Pubmed Style

Murukesan P, Kesavan K. Evaluation of analgesic properties of petroleum ether extract of Zingiber officinale. Natl J Physiol Pharm Pharmacol. 2022; 12(7): 1008-1012. doi:10.5455/njppp.2022.12.05228202220052022


Web Style

Murukesan P, Kesavan K. Evaluation of analgesic properties of petroleum ether extract of Zingiber officinale. https://www.njppp.com/?mno=40186 [Access: January 03, 2023]. doi:10.5455/njppp.2022.12.05228202220052022


AMA (American Medical Association) Style

Murukesan P, Kesavan K. Evaluation of analgesic properties of petroleum ether extract of Zingiber officinale. Natl J Physiol Pharm Pharmacol. 2022; 12(7): 1008-1012. doi:10.5455/njppp.2022.12.05228202220052022



Vancouver/ICMJE Style

Murukesan P, Kesavan K. Evaluation of analgesic properties of petroleum ether extract of Zingiber officinale. Natl J Physiol Pharm Pharmacol. (2022), [cited January 03, 2023]; 12(7): 1008-1012. doi:10.5455/njppp.2022.12.05228202220052022



Harvard Style

Murukesan, P. & Kesavan, . K. (2022) Evaluation of analgesic properties of petroleum ether extract of Zingiber officinale. Natl J Physiol Pharm Pharmacol, 12 (7), 1008-1012. doi:10.5455/njppp.2022.12.05228202220052022



Turabian Style

Murukesan, Prasanth, and Kala Kesavan. 2022. Evaluation of analgesic properties of petroleum ether extract of Zingiber officinale. National Journal of Physiology, Pharmacy and Pharmacology, 12 (7), 1008-1012. doi:10.5455/njppp.2022.12.05228202220052022



Chicago Style

Murukesan, Prasanth, and Kala Kesavan. "Evaluation of analgesic properties of petroleum ether extract of Zingiber officinale." National Journal of Physiology, Pharmacy and Pharmacology 12 (2022), 1008-1012. doi:10.5455/njppp.2022.12.05228202220052022



MLA (The Modern Language Association) Style

Murukesan, Prasanth, and Kala Kesavan. "Evaluation of analgesic properties of petroleum ether extract of Zingiber officinale." National Journal of Physiology, Pharmacy and Pharmacology 12.7 (2022), 1008-1012. Print. doi:10.5455/njppp.2022.12.05228202220052022



APA (American Psychological Association) Style

Murukesan, P. & Kesavan, . K. (2022) Evaluation of analgesic properties of petroleum ether extract of Zingiber officinale. National Journal of Physiology, Pharmacy and Pharmacology, 12 (7), 1008-1012. doi:10.5455/njppp.2022.12.05228202220052022