A randomized comparative study to assess the efficacy of topical luliconazole versus topical clotrimazole in tinea corporis and tinea cruris

LAKSHMI PRABHA M; MEENAKSHI B; NIRMALA DEVI P; EZHIL RAMYA J; REVATHY BALAN C

doi:10.5455/njppp.2019.9.0415222052019

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Original Research
Online Published: 08 Jun 2019

Natl J Physiol Pharm Pharmacol. 2019; 9(8): 756-762

doi: 10.5455/njppp.2019.9.0415222052019

A randomized comparative study to assess the efficacy of topical luliconazole versus topical clotrimazole in tinea corporis and tinea cruris

Lakshmi Prabha M, Meenakshi B, Nirmala Devi P, Ezhil Ramya J, Revathy Balan C.

Cited By:2

Abstract
Background: Dermatophytosis is a common cutaneous infection in India with prevalence varying from 36.6% to 78.4%. Topical azoles and allylamines are used to treat localized dermatophytosis but has disadvantages such as long duration of therapy, poor compliance, and high relapse rate. Luliconazole is a newer topical imidazole antifungal applied once daily with greater reservoir property in stratum corneum.

Aims and Objective: The aim of the study was to compare the efficacy of topical luliconazole versus topical clotrimazole in tinea corporis and tinea cruris.

Materials and Methods: An open-labeled randomized comparative study in the Dermatology Outpatient Department of Tirunelveli Medical College done from September 2015 to September 2016. Patients with tinea corporis/tinea cruris were randomized into two groups to receive topical luliconazole cream once daily for 2 weeks or topical clotrimazole cream twice daily for 4 weeks. Scrapings from lesion were taken for mycological assessment. Clinical and mycological cure was assessed at each visit.

Results: Each group had 50 patients. At the end of 1st week, the mycological cure was 78% in luliconazole and 12% in clotrimazole (P < 0.05) and complete clearance was achieved in 11 patients (22%) in luliconazole group. By the end, 98% got cured in luliconazole group and 80% in the clotrimazole group (P < 0.05). Relapse occurred in 20% in clotrimazole group as against 4% in luliconazole group (P < 0.05). Both groups showed only mild application site reactions except one patient who developed hypersensitivity to clotrimazole.

Conclusions: Topical luliconazole was better in achieving faster mycological and clinical cure with lower relapse.

Key words: Clotrimazole; Dermatophytosis; Efficacy; Luliconazole

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How to Cite this Article

Pubmed Style

M LP, B M, P ND, J ER, C RB. A randomized comparative study to assess the efficacy of topical luliconazole versus topical clotrimazole in tinea corporis and tinea cruris. Natl J Physiol Pharm Pharmacol. 2019; 9(8): 756-762. doi:10.5455/njppp.2019.9.0415222052019

Web Style

M LP, B M, P ND, J ER, C RB. A randomized comparative study to assess the efficacy of topical luliconazole versus topical clotrimazole in tinea corporis and tinea cruris. https://www.njppp.com/?mno=44541 [Access: November 01, 2025]. doi:10.5455/njppp.2019.9.0415222052019

AMA (American Medical Association) Style

M LP, B M, P ND, J ER, C RB. A randomized comparative study to assess the efficacy of topical luliconazole versus topical clotrimazole in tinea corporis and tinea cruris. Natl J Physiol Pharm Pharmacol. 2019; 9(8): 756-762. doi:10.5455/njppp.2019.9.0415222052019

Vancouver/ICMJE Style

M LP, B M, P ND, J ER, C RB. A randomized comparative study to assess the efficacy of topical luliconazole versus topical clotrimazole in tinea corporis and tinea cruris. Natl J Physiol Pharm Pharmacol. (2019), [cited November 01, 2025]; 9(8): 756-762. doi:10.5455/njppp.2019.9.0415222052019

Harvard Style

M, L. P., B, . M., P, . N. D., J, . E. R. & C, . R. B. (2019) A randomized comparative study to assess the efficacy of topical luliconazole versus topical clotrimazole in tinea corporis and tinea cruris. Natl J Physiol Pharm Pharmacol, 9 (8), 756-762. doi:10.5455/njppp.2019.9.0415222052019

Turabian Style

M, Lakshmi Prabha, Meenakshi B, Nirmala Devi P, Ezhil Ramya J, and Revathy Balan C. 2019. A randomized comparative study to assess the efficacy of topical luliconazole versus topical clotrimazole in tinea corporis and tinea cruris. National Journal of Physiology, Pharmacy and Pharmacology, 9 (8), 756-762. doi:10.5455/njppp.2019.9.0415222052019

Chicago Style

M, Lakshmi Prabha, Meenakshi B, Nirmala Devi P, Ezhil Ramya J, and Revathy Balan C. "A randomized comparative study to assess the efficacy of topical luliconazole versus topical clotrimazole in tinea corporis and tinea cruris." National Journal of Physiology, Pharmacy and Pharmacology 9 (2019), 756-762. doi:10.5455/njppp.2019.9.0415222052019

MLA (The Modern Language Association) Style

M, Lakshmi Prabha, Meenakshi B, Nirmala Devi P, Ezhil Ramya J, and Revathy Balan C. "A randomized comparative study to assess the efficacy of topical luliconazole versus topical clotrimazole in tinea corporis and tinea cruris." National Journal of Physiology, Pharmacy and Pharmacology 9.8 (2019), 756-762. Print. doi:10.5455/njppp.2019.9.0415222052019

APA (American Psychological Association) Style

M, L. P., B, . M., P, . N. D., J, . E. R. & C, . R. B. (2019) A randomized comparative study to assess the efficacy of topical luliconazole versus topical clotrimazole in tinea corporis and tinea cruris. National Journal of Physiology, Pharmacy and Pharmacology, 9 (8), 756-762. doi:10.5455/njppp.2019.9.0415222052019

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