E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research 


Vitamin D and autoimmune thyroiditis in children – A prospective case–control study

Gopi Kiran, Bhadra Singh, Mohammed Mujtaba Qureshi.

Abstract
Background: The deficiency or insufficiency of Vitamin D has been widely reported to be linked with autoimmune thyroid diseases. Several studies were evaluated the immunomodulatory effects of 25 hydroxyvitamin D (25(OH)D) and its counterparts in autoimmune diseases especially in autoimmune thyroiditis.

Aim and Objectives: The aim of the study was to assess the Vitamin D status in children with autoimmune thyroiditis at tertiary care hospital, Sangareddy, Telangana.

Materials and Methods: A source of 80 newly diagnosed cases with autoimmune thyroiditis and similar volume of age and sex matched control subjects between ≥6 and 12 years were included in the study. Parameters such as thyroid function tests, serum calcium, serum phosphorus, serum alkaline phosphatase, 25(OH)D, and antithyroid antibodies levels were assessed. The antithyroid antibodies levels were assessed through chemiluminescence assay.

Results: The 25(OH)D levels were 14.98ng/ml in cases and 17.46 ng/ml in control subjects. The mean levels of 25(OH)D, serum calcium, and alkaline phosphatase were statistically significant (P < 0.05).

Conclusion: The levels of Vitamin D and four groups of antithyroid peroxidase antibody and antithyroglobulin antibody among cases and control subjects were not significant (P > 0.05). The estimation of Vitamin D in high-risk group may be helpful in designing the treatment strategies to decrease the morbidity.

Key words: 25 Hydroxyvitamin D; Antithyroid Peroxidase Antibody; Antithyroglobulin Antibody; Autoimmune Thyroiditis


 
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Pubmed Style

Kiran G, Singh B, Qureshi MM. Vitamin D and autoimmune thyroiditis in children – A prospective case–control study. Natl J Physiol Pharm Pharmacol. 2022; 12(12): 1984-1987. doi:10.5455/njppp.2022.12.03146202202042022


Web Style

Kiran G, Singh B, Qureshi MM. Vitamin D and autoimmune thyroiditis in children – A prospective case–control study. https://www.njppp.com/?mno=4972 [Access: February 01, 2023]. doi:10.5455/njppp.2022.12.03146202202042022


AMA (American Medical Association) Style

Kiran G, Singh B, Qureshi MM. Vitamin D and autoimmune thyroiditis in children – A prospective case–control study. Natl J Physiol Pharm Pharmacol. 2022; 12(12): 1984-1987. doi:10.5455/njppp.2022.12.03146202202042022



Vancouver/ICMJE Style

Kiran G, Singh B, Qureshi MM. Vitamin D and autoimmune thyroiditis in children – A prospective case–control study. Natl J Physiol Pharm Pharmacol. (2022), [cited February 01, 2023]; 12(12): 1984-1987. doi:10.5455/njppp.2022.12.03146202202042022



Harvard Style

Kiran, G., Singh, . B. & Qureshi, . M. M. (2022) Vitamin D and autoimmune thyroiditis in children – A prospective case–control study. Natl J Physiol Pharm Pharmacol, 12 (12), 1984-1987. doi:10.5455/njppp.2022.12.03146202202042022



Turabian Style

Kiran, Gopi, Bhadra Singh, and Mohammed Mujtaba Qureshi. 2022. Vitamin D and autoimmune thyroiditis in children – A prospective case–control study. National Journal of Physiology, Pharmacy and Pharmacology, 12 (12), 1984-1987. doi:10.5455/njppp.2022.12.03146202202042022



Chicago Style

Kiran, Gopi, Bhadra Singh, and Mohammed Mujtaba Qureshi. "Vitamin D and autoimmune thyroiditis in children – A prospective case–control study." National Journal of Physiology, Pharmacy and Pharmacology 12 (2022), 1984-1987. doi:10.5455/njppp.2022.12.03146202202042022



MLA (The Modern Language Association) Style

Kiran, Gopi, Bhadra Singh, and Mohammed Mujtaba Qureshi. "Vitamin D and autoimmune thyroiditis in children – A prospective case–control study." National Journal of Physiology, Pharmacy and Pharmacology 12.12 (2022), 1984-1987. Print. doi:10.5455/njppp.2022.12.03146202202042022



APA (American Psychological Association) Style

Kiran, G., Singh, . B. & Qureshi, . M. M. (2022) Vitamin D and autoimmune thyroiditis in children – A prospective case–control study. National Journal of Physiology, Pharmacy and Pharmacology, 12 (12), 1984-1987. doi:10.5455/njppp.2022.12.03146202202042022