E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research 


Spirometry in adult systemic lupus erythematosus and its relation with disease duration: A cross-sectional study in Eastern India

Prasenjit Majumdar, Md. Mahboob Alam, Subhankar Haldar, Ardhendu Mazumdar.

Abstract
Background: Although symptomatic interstitial lung disease (ILD) complicates in 3–8% of patients with systemic lupus erythematosus (SLE), subclinical ILD is common and has been described in up to one-third of patients.

Aims and Objectives: Objective was spirometric evaluation of adult SLE patients having no pulmonary symptoms.

Materials and Methods: A cross-sectional study was carried out involving adult SLE. Forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1), FEV1/FVC ratio, forced expiratory flow (FEF) between 25 and 75% of vital capacity (FEF25–75%), and peak expiratory flow rate (PEFR) were measured. Pearson’s correlation analysis was used to determine the correlation of disease duration with spirometric parameters.

Results: Of 74 patients (age 18–50 years), six were male. Mean age, height, and weight were 29.65 years, 154.1 cm, and 52.75 kg, respectively. Mean duration of the disease was 4.5 years. Sixty patients (five males among them) were in remission with SLE Disease Activity Index score of 0. None had chronic cough or any respiratory distress at rest or with day-to-day activities. Overall, 34 (46%) patients had normal spirometry. About 56% of female and 33% of male patients had abnormal spirometry. About 49% of female patients had restrictive pattern of abnormality while 9% had obstructive disease. All patients had normal PEFR. Disease duration did not significantly correlate with any of the spirometric parameters or their percent-predicted values.

Conclusion: Periodic spirometry of adult SLE patients can be a cost-effective alternative in detecting subclinical pulmonary changes.

Key words: Systemic Lupus Erythematosus; Spirometry; Adult


 
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How to Cite this Article
Pubmed Style

Majumdar P, Alam MM, Haldar S, Mazumdar A. Spirometry in adult systemic lupus erythematosus and its relation with disease duration: A cross-sectional study in Eastern India. Natl J Physiol Pharm Pharmacol. 2019; 9(9): 874-877. doi:10.5455/njppp.2019.9.0622222062019


Web Style

Majumdar P, Alam MM, Haldar S, Mazumdar A. Spirometry in adult systemic lupus erythematosus and its relation with disease duration: A cross-sectional study in Eastern India. https://www.njppp.com/?mno=53340 [Access: December 01, 2022]. doi:10.5455/njppp.2019.9.0622222062019


AMA (American Medical Association) Style

Majumdar P, Alam MM, Haldar S, Mazumdar A. Spirometry in adult systemic lupus erythematosus and its relation with disease duration: A cross-sectional study in Eastern India. Natl J Physiol Pharm Pharmacol. 2019; 9(9): 874-877. doi:10.5455/njppp.2019.9.0622222062019



Vancouver/ICMJE Style

Majumdar P, Alam MM, Haldar S, Mazumdar A. Spirometry in adult systemic lupus erythematosus and its relation with disease duration: A cross-sectional study in Eastern India. Natl J Physiol Pharm Pharmacol. (2019), [cited December 01, 2022]; 9(9): 874-877. doi:10.5455/njppp.2019.9.0622222062019



Harvard Style

Majumdar, P., Alam, . M. M., Haldar, . S. & Mazumdar, . A. (2019) Spirometry in adult systemic lupus erythematosus and its relation with disease duration: A cross-sectional study in Eastern India. Natl J Physiol Pharm Pharmacol, 9 (9), 874-877. doi:10.5455/njppp.2019.9.0622222062019



Turabian Style

Majumdar, Prasenjit, Md. Mahboob Alam, Subhankar Haldar, and Ardhendu Mazumdar. 2019. Spirometry in adult systemic lupus erythematosus and its relation with disease duration: A cross-sectional study in Eastern India. National Journal of Physiology, Pharmacy and Pharmacology, 9 (9), 874-877. doi:10.5455/njppp.2019.9.0622222062019



Chicago Style

Majumdar, Prasenjit, Md. Mahboob Alam, Subhankar Haldar, and Ardhendu Mazumdar. "Spirometry in adult systemic lupus erythematosus and its relation with disease duration: A cross-sectional study in Eastern India." National Journal of Physiology, Pharmacy and Pharmacology 9 (2019), 874-877. doi:10.5455/njppp.2019.9.0622222062019



MLA (The Modern Language Association) Style

Majumdar, Prasenjit, Md. Mahboob Alam, Subhankar Haldar, and Ardhendu Mazumdar. "Spirometry in adult systemic lupus erythematosus and its relation with disease duration: A cross-sectional study in Eastern India." National Journal of Physiology, Pharmacy and Pharmacology 9.9 (2019), 874-877. Print. doi:10.5455/njppp.2019.9.0622222062019



APA (American Psychological Association) Style

Majumdar, P., Alam, . M. M., Haldar, . S. & Mazumdar, . A. (2019) Spirometry in adult systemic lupus erythematosus and its relation with disease duration: A cross-sectional study in Eastern India. National Journal of Physiology, Pharmacy and Pharmacology, 9 (9), 874-877. doi:10.5455/njppp.2019.9.0622222062019