E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research 


The antidepressant activity of the alcoholic extract of Withania coagulans fruits in Swiss albino mice by forced swimming test

Amit S Kamdi, Pankaj N Bohra, Suvarna M Kalambe, Ajay R Chandrakapure.

Cited by (1)

Abstract
Background: Depression is one of the most upsetting mood disorders. The various antidepressant medications used today are having the adverse drug effects. Withania coagulans – a vulnerable species, is not explored much for its effects on mood except in the late 70s. Therefore, it was thought worthy to explore anti-depressive activities of the alcoholic extract of W. coagulans fruits in Swiss albino mice using forced swimming test.

Aims and Objectives: This study aims to study the antidepressant activities of the alcoholic extract of W. coagulans fruits in Swiss albino mice using forced swimming test.

Materials and Methods: Forced swimming test was used for assessing the anti-depressive activity of W. coagulans fruits alcoholic extract. If the extract had antidepressant activity, then it was expected that the period of mobility would increase and immobility would decrease. This decrease in immobility, if found statistically significant, was considered for antidepressant activity.

Results: There was statistically highly significant (P < 0.001) association observed between alcoholic extract of W. coagulans fruits with depressive effect on mood in Swiss albino mice.

Conclusion: The alcoholic extract of W. coagulans fruits did not demonstrate antidepressant activity in Swiss albino mice. In contrast, it revealed depressive effect on the mood in the forced swimming test.

Key words: Antidepressant; Swiss Albino Mice; Alcoholic Extract; Withania coagulans; Forced Swimming Test


 
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This Article Cited By the following articles

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How to Cite this Article
Pubmed Style

Kamdi AS, Bohra PN, Kalambe SM, Chandrakapure AR. The antidepressant activity of the alcoholic extract of Withania coagulans fruits in Swiss albino mice by forced swimming test. Natl J Physiol Pharm Pharmacol. 2019; 9(9): 904-906. doi:10.5455/njppp.2019.9.0622502072019


Web Style

Kamdi AS, Bohra PN, Kalambe SM, Chandrakapure AR. The antidepressant activity of the alcoholic extract of Withania coagulans fruits in Swiss albino mice by forced swimming test. https://www.njppp.com/?mno=53912 [Access: December 01, 2022]. doi:10.5455/njppp.2019.9.0622502072019


AMA (American Medical Association) Style

Kamdi AS, Bohra PN, Kalambe SM, Chandrakapure AR. The antidepressant activity of the alcoholic extract of Withania coagulans fruits in Swiss albino mice by forced swimming test. Natl J Physiol Pharm Pharmacol. 2019; 9(9): 904-906. doi:10.5455/njppp.2019.9.0622502072019



Vancouver/ICMJE Style

Kamdi AS, Bohra PN, Kalambe SM, Chandrakapure AR. The antidepressant activity of the alcoholic extract of Withania coagulans fruits in Swiss albino mice by forced swimming test. Natl J Physiol Pharm Pharmacol. (2019), [cited December 01, 2022]; 9(9): 904-906. doi:10.5455/njppp.2019.9.0622502072019



Harvard Style

Kamdi, A. S., Bohra, . P. N., Kalambe, . S. M. & Chandrakapure, . A. R. (2019) The antidepressant activity of the alcoholic extract of Withania coagulans fruits in Swiss albino mice by forced swimming test. Natl J Physiol Pharm Pharmacol, 9 (9), 904-906. doi:10.5455/njppp.2019.9.0622502072019



Turabian Style

Kamdi, Amit S, Pankaj N Bohra, Suvarna M Kalambe, and Ajay R Chandrakapure. 2019. The antidepressant activity of the alcoholic extract of Withania coagulans fruits in Swiss albino mice by forced swimming test. National Journal of Physiology, Pharmacy and Pharmacology, 9 (9), 904-906. doi:10.5455/njppp.2019.9.0622502072019



Chicago Style

Kamdi, Amit S, Pankaj N Bohra, Suvarna M Kalambe, and Ajay R Chandrakapure. "The antidepressant activity of the alcoholic extract of Withania coagulans fruits in Swiss albino mice by forced swimming test." National Journal of Physiology, Pharmacy and Pharmacology 9 (2019), 904-906. doi:10.5455/njppp.2019.9.0622502072019



MLA (The Modern Language Association) Style

Kamdi, Amit S, Pankaj N Bohra, Suvarna M Kalambe, and Ajay R Chandrakapure. "The antidepressant activity of the alcoholic extract of Withania coagulans fruits in Swiss albino mice by forced swimming test." National Journal of Physiology, Pharmacy and Pharmacology 9.9 (2019), 904-906. Print. doi:10.5455/njppp.2019.9.0622502072019



APA (American Psychological Association) Style

Kamdi, A. S., Bohra, . P. N., Kalambe, . S. M. & Chandrakapure, . A. R. (2019) The antidepressant activity of the alcoholic extract of Withania coagulans fruits in Swiss albino mice by forced swimming test. National Journal of Physiology, Pharmacy and Pharmacology, 9 (9), 904-906. doi:10.5455/njppp.2019.9.0622502072019