E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research

Online Publishing Date:
31 / 12 / 2022

 


An experimental study evaluating antidepressant activity of methanolic leaf and fruit pulp extracts of Aegle marmelos in Wistar rats

Kumar Pojala, Vinay Kumar Sayeli.


Abstract
Background: Aegle marmelos (common name: Bel/wood apple/Tamil name: Vilvam/Telugu name: Sandiliyamu) has numerous therapeutic values in Indian traditional systems of medicine. The crude extracts of various parts of this plant have numerous properties including anti-inflammatory, antiulcer, antipyretic, and antioxidant. This study was taken to explore the antidepressant activity of A. marmelos.

Aim and Objectives: The objectives of the study are as follows: (1) To identify the antidepressant activity of methanolic leaf and the fruit pulp extracts of A. marmelos. (2) To compare the dose-dependent effect of methanolic leaf and the fruit pulp extracts of A. marmelos with the standard drug, Imipramine.

Materials and Methods: Forced swim test (FST) and shock-induced depression (SID) models were used in this study. Six groups (n = 6) of Wistar rats (150–200 g) of either sex were used for each experimental model. About 1% Carboxymethylcellulose (CMC-1), 20 mg/kg of Imipramine (Imi-20), 150 and 300 mg/kg of methanolic leaf extract, and 150 and 300 mg/kg of methanolic fruit pulp extract were given to Groups 1–6, respectively, by oral route for 7 days. The number of movements was measured using an Photoactometer for SID and the duration of immobility (in sec) were measured for FST.

Results: Data were statistically analyzed by one-way ANOVA for FST and by Kruskal–Wallis test for SID, P < 0.05 was considered statistically significant. Both standard and test drugs exhibited significant antidepressant activity.

Conclusion: Fruit pulp extract (300 mg/kg) of A. marmelos has demonstrated maximum antidepressant activity in FST and SID models, which was comparable to standard drug.

Key words: Antidepressant; Aegle marmelos; Forced Swim Test; Shock Induced Depression; Imipramine


 
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Pubmed Style

Pojala K, Sayeli VK. An experimental study evaluating antidepressant activity of methanolic leaf and fruit pulp extracts of Aegle marmelos in Wistar rats. Natl J Physiol Pharm Pharmacol. 2023; 13(7): 1456-1460. doi:10.5455/njppp.2023.13.12588202223122022


Web Style

Pojala K, Sayeli VK. An experimental study evaluating antidepressant activity of methanolic leaf and fruit pulp extracts of Aegle marmelos in Wistar rats. https://www.njppp.com/?mno=93402 [Access: March 14, 2024]. doi:10.5455/njppp.2023.13.12588202223122022


AMA (American Medical Association) Style

Pojala K, Sayeli VK. An experimental study evaluating antidepressant activity of methanolic leaf and fruit pulp extracts of Aegle marmelos in Wistar rats. Natl J Physiol Pharm Pharmacol. 2023; 13(7): 1456-1460. doi:10.5455/njppp.2023.13.12588202223122022



Vancouver/ICMJE Style

Pojala K, Sayeli VK. An experimental study evaluating antidepressant activity of methanolic leaf and fruit pulp extracts of Aegle marmelos in Wistar rats. Natl J Physiol Pharm Pharmacol. (2023), [cited March 14, 2024]; 13(7): 1456-1460. doi:10.5455/njppp.2023.13.12588202223122022



Harvard Style

Pojala, K. & Sayeli, . V. K. (2023) An experimental study evaluating antidepressant activity of methanolic leaf and fruit pulp extracts of Aegle marmelos in Wistar rats. Natl J Physiol Pharm Pharmacol, 13 (7), 1456-1460. doi:10.5455/njppp.2023.13.12588202223122022



Turabian Style

Pojala, Kumar, and Vinay Kumar Sayeli. 2023. An experimental study evaluating antidepressant activity of methanolic leaf and fruit pulp extracts of Aegle marmelos in Wistar rats. National Journal of Physiology, Pharmacy and Pharmacology, 13 (7), 1456-1460. doi:10.5455/njppp.2023.13.12588202223122022



Chicago Style

Pojala, Kumar, and Vinay Kumar Sayeli. "An experimental study evaluating antidepressant activity of methanolic leaf and fruit pulp extracts of Aegle marmelos in Wistar rats." National Journal of Physiology, Pharmacy and Pharmacology 13 (2023), 1456-1460. doi:10.5455/njppp.2023.13.12588202223122022



MLA (The Modern Language Association) Style

Pojala, Kumar, and Vinay Kumar Sayeli. "An experimental study evaluating antidepressant activity of methanolic leaf and fruit pulp extracts of Aegle marmelos in Wistar rats." National Journal of Physiology, Pharmacy and Pharmacology 13.7 (2023), 1456-1460. Print. doi:10.5455/njppp.2023.13.12588202223122022



APA (American Psychological Association) Style

Pojala, K. & Sayeli, . V. K. (2023) An experimental study evaluating antidepressant activity of methanolic leaf and fruit pulp extracts of Aegle marmelos in Wistar rats. National Journal of Physiology, Pharmacy and Pharmacology, 13 (7), 1456-1460. doi:10.5455/njppp.2023.13.12588202223122022