Adverse drug reaction monitoring of antitubercular drugs during intensive phase at tertiary care medical college hospital: A prospective study

Manju Ramakrishnan; Nisha Maheshwari Y; Ezhil Ramya J; Krishnamoorthy K

doi:10.5455/njppp.2020.10.07179202017072020

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Original Research
Online Published: 27 Jul 2020

Natl J Physiol Pharm Pharmacol. 2020; 10(11): 976-980

doi: 10.5455/njppp.2020.10.07179202017072020

Adverse drug reaction monitoring of antitubercular drugs during intensive phase at tertiary care medical college hospital: A prospective study

Manju Ramakrishnan, Nisha Maheshwari Y, Ezhil Ramya J, Krishnamoorthy K.

Cited By:9

Abstract
Background: Tuberculosis (TB) an infectious disease can cause serious economic burden to the country and to the patients. About quarter of the world TB cases are reported in India. As many newer and newer drugs emerge it creates newer and rare side effects which may lead to the discontinuation of the drug and finally end up in multi-drug resistant TB. Hence, monitoring of these related adverse drug reactions (ADRs) is very essential wherein the drug causing ADR can be detected and appropriate therapeutic regimen can be tailored to the patient and thus reduce the economic burden.

Aim and Objective: The aim of the study was to assess the rate of prevalence of ADR with antitubercular drugs during intensive phase of treatment in Tirunelveli Medical College Hospital (TVMCH).

Materials and Methods: The sample size of 100 patients who were diagnosed with pulmonary TB and undergoing treatment in TVMCH was observed for any adverse effects. The observed adverse effects were recorded using Adverse Drug Reactions reporting form. The casualty and the severity assessment were done using WHO-Uppsala Monitoring Centre Criteria and Hartwig-Siegel Scale, respectively.

Results: Among 100 pulmonary TB patients receiving fixed-dose combination pills the most commonly observed adverse effects are Nausea (20 cases), hepatitis (19 cases), gastritis (15 cases), and other side effects such as pruritus, abdominal cramps, and diarrhea.

Conclusion: Early identification, reporting, and management of ADRs remain key factors in the treatment of a newly diagnosed TB patients. It can be revised even more to lower the severity levels and achieve elimination of TB.

Key words: Adverse Effects; Casualty Assessment; Severity Assessment; Hartwig-Siegel Scale; WHO- Uppsala Monitoring Centre criteria

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Pubmed Style

Ramakrishnan M, Y NM, J ER, K K. Adverse drug reaction monitoring of antitubercular drugs during intensive phase at tertiary care medical college hospital: A prospective study. Natl J Physiol Pharm Pharmacol. 2020; 10(11): 976-980. doi:10.5455/njppp.2020.10.07179202017072020

Web Style

Ramakrishnan M, Y NM, J ER, K K. Adverse drug reaction monitoring of antitubercular drugs during intensive phase at tertiary care medical college hospital: A prospective study. https://www.njppp.com/?mno=95787 [Access: April 17, 2025]. doi:10.5455/njppp.2020.10.07179202017072020

AMA (American Medical Association) Style

Ramakrishnan M, Y NM, J ER, K K. Adverse drug reaction monitoring of antitubercular drugs during intensive phase at tertiary care medical college hospital: A prospective study. Natl J Physiol Pharm Pharmacol. 2020; 10(11): 976-980. doi:10.5455/njppp.2020.10.07179202017072020

Vancouver/ICMJE Style

Ramakrishnan M, Y NM, J ER, K K. Adverse drug reaction monitoring of antitubercular drugs during intensive phase at tertiary care medical college hospital: A prospective study. Natl J Physiol Pharm Pharmacol. (2020), [cited April 17, 2025]; 10(11): 976-980. doi:10.5455/njppp.2020.10.07179202017072020

Harvard Style

Ramakrishnan, M., Y, . N. M., J, . E. R. & K, . K. (2020) Adverse drug reaction monitoring of antitubercular drugs during intensive phase at tertiary care medical college hospital: A prospective study. Natl J Physiol Pharm Pharmacol, 10 (11), 976-980. doi:10.5455/njppp.2020.10.07179202017072020

Turabian Style

Ramakrishnan, Manju, Nisha Maheshwari Y, Ezhil Ramya J, and Krishnamoorthy K. 2020. Adverse drug reaction monitoring of antitubercular drugs during intensive phase at tertiary care medical college hospital: A prospective study. National Journal of Physiology, Pharmacy and Pharmacology, 10 (11), 976-980. doi:10.5455/njppp.2020.10.07179202017072020

Chicago Style

Ramakrishnan, Manju, Nisha Maheshwari Y, Ezhil Ramya J, and Krishnamoorthy K. "Adverse drug reaction monitoring of antitubercular drugs during intensive phase at tertiary care medical college hospital: A prospective study." National Journal of Physiology, Pharmacy and Pharmacology 10 (2020), 976-980. doi:10.5455/njppp.2020.10.07179202017072020

MLA (The Modern Language Association) Style

Ramakrishnan, Manju, Nisha Maheshwari Y, Ezhil Ramya J, and Krishnamoorthy K. "Adverse drug reaction monitoring of antitubercular drugs during intensive phase at tertiary care medical college hospital: A prospective study." National Journal of Physiology, Pharmacy and Pharmacology 10.11 (2020), 976-980. Print. doi:10.5455/njppp.2020.10.07179202017072020

APA (American Psychological Association) Style

Ramakrishnan, M., Y, . N. M., J, . E. R. & K, . K. (2020) Adverse drug reaction monitoring of antitubercular drugs during intensive phase at tertiary care medical college hospital: A prospective study. National Journal of Physiology, Pharmacy and Pharmacology, 10 (11), 976-980. doi:10.5455/njppp.2020.10.07179202017072020

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