E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research

Online Publishing Date:
02 / 01 / 2023

 


Hematological abnormalities in patients of alcoholic chronic liver disease – A cross-sectional study in a tertiary care hospital in Eastern Zone of India

Abhranil Dhar, Shyamal Kanti Pal, Brahmarshi Das, Partha Mandal.


Abstract
Background: Alcohol abuse is on increasing trend in world as well as in India, especially in young population. Long-term alcohol intake may leads to alcoholic chronic liver disease which may turns in to end stage liver diseases. Alcoholic chronic liver disease is associated with some hematological abnormalities which if detected at early stage may provide clear therapeutic implications in managing these patients and reducing the adverse events.

Aims and Objectives: Our aim of the study was to identify various hematological abnormalities in patients of alcoholic chronic liver disease.

Materials and Methods: This hospital-based cross-sectional study includes 100 randomly selected patients with alcoholic chronic liver disease attending Out-Patient Department and admitted in General Medicine ward of Burdwan Medical College satisfying the inclusion and exclusion criteria. Data were analyzed for hemoglobin (Hb), red blood cell (RBC), total leukocyte count (TLC), platelet count, mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), MCH concentration, and prothrombin time-international normalized ratio. The mean and standard deviation, percentages, and ratio were calculated and presented in the form of tables with the help of SPSS (IBM) ver-23. P < 0.05 was considered statistically significant.

Results: Hematological abnormalities were found more with increased duration of alcohol consumption. Prolonged bleeding time was observed in 23% cases and prolonged clotting time was observed in 21% cases. Maximum patients belonged to Child–Pugh grade C. Hematological abnormalities were more in patients belonging to Child–Pugh grade C. Hb, RBC, platelet, and packed cell volume were significantly lower in patients belonging to Child–Pugh class C, whereas TLC, MCV, and MCH were significantly higher in class C.

Conclusion: It can be concluded that related hematological changes, which are common in alcoholic chronic liver disease endanger the lives of these patients. They should be detected and corrected at earliest to minimize morbidity and mortality.

Key words: Alcoholic Chronic Liver Diseases; Hematological Parameters; Alcohol; Cirrhosis


 
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How to Cite this Article
Pubmed Style

Dhar A, Pal SK, Das B, Mandal P. Hematological abnormalities in patients of alcoholic chronic liver disease – A cross-sectional study in a tertiary care hospital in Eastern Zone of India. Natl J Physiol Pharm Pharmacol. 2023; 13(2): 374-379. doi:10.5455/njppp.2023.13.12600202225122022


Web Style

Dhar A, Pal SK, Das B, Mandal P. Hematological abnormalities in patients of alcoholic chronic liver disease – A cross-sectional study in a tertiary care hospital in Eastern Zone of India. https://www.njppp.com/?mno=103648 [Access: March 15, 2024]. doi:10.5455/njppp.2023.13.12600202225122022


AMA (American Medical Association) Style

Dhar A, Pal SK, Das B, Mandal P. Hematological abnormalities in patients of alcoholic chronic liver disease – A cross-sectional study in a tertiary care hospital in Eastern Zone of India. Natl J Physiol Pharm Pharmacol. 2023; 13(2): 374-379. doi:10.5455/njppp.2023.13.12600202225122022



Vancouver/ICMJE Style

Dhar A, Pal SK, Das B, Mandal P. Hematological abnormalities in patients of alcoholic chronic liver disease – A cross-sectional study in a tertiary care hospital in Eastern Zone of India. Natl J Physiol Pharm Pharmacol. (2023), [cited March 15, 2024]; 13(2): 374-379. doi:10.5455/njppp.2023.13.12600202225122022



Harvard Style

Dhar, A., Pal, . S. K., Das, . B. & Mandal, . P. (2023) Hematological abnormalities in patients of alcoholic chronic liver disease – A cross-sectional study in a tertiary care hospital in Eastern Zone of India. Natl J Physiol Pharm Pharmacol, 13 (2), 374-379. doi:10.5455/njppp.2023.13.12600202225122022



Turabian Style

Dhar, Abhranil, Shyamal Kanti Pal, Brahmarshi Das, and Partha Mandal. 2023. Hematological abnormalities in patients of alcoholic chronic liver disease – A cross-sectional study in a tertiary care hospital in Eastern Zone of India. National Journal of Physiology, Pharmacy and Pharmacology, 13 (2), 374-379. doi:10.5455/njppp.2023.13.12600202225122022



Chicago Style

Dhar, Abhranil, Shyamal Kanti Pal, Brahmarshi Das, and Partha Mandal. "Hematological abnormalities in patients of alcoholic chronic liver disease – A cross-sectional study in a tertiary care hospital in Eastern Zone of India." National Journal of Physiology, Pharmacy and Pharmacology 13 (2023), 374-379. doi:10.5455/njppp.2023.13.12600202225122022



MLA (The Modern Language Association) Style

Dhar, Abhranil, Shyamal Kanti Pal, Brahmarshi Das, and Partha Mandal. "Hematological abnormalities in patients of alcoholic chronic liver disease – A cross-sectional study in a tertiary care hospital in Eastern Zone of India." National Journal of Physiology, Pharmacy and Pharmacology 13.2 (2023), 374-379. Print. doi:10.5455/njppp.2023.13.12600202225122022



APA (American Psychological Association) Style

Dhar, A., Pal, . S. K., Das, . B. & Mandal, . P. (2023) Hematological abnormalities in patients of alcoholic chronic liver disease – A cross-sectional study in a tertiary care hospital in Eastern Zone of India. National Journal of Physiology, Pharmacy and Pharmacology, 13 (2), 374-379. doi:10.5455/njppp.2023.13.12600202225122022