E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research

Online Publishing Date:
27 / 01 / 2023

 


Pattern of cutaneous adverse drug reactions in an adverse drug monitoring center at a tertiary care hospital in Kerala

Shobha Parvathy, Messaline Sunitha.


Abstract
Background: Pre-marketing clinical trials can filter only about 50% of the drug reaction. Hence, to prevent the morbidity and mortality due to severe cutaneous reactions early detection, evaluation and monitoring of adverse drug reaction (ADR) especially cutaneous ADR (CADR) are mandatory. Hence, it is imperative that we update our knowledge of the precise nature of ADR which will prevent the reactions as well as to find the offending drug.

Aim and Objectives: The aim of the study was to evaluate the pattern of CADR, the suspected drugs and to perform the causality assessment using WHO casualty assessment scale.

Materials and Methods: A retrospective descriptive study was done using the data reported to ADR monitoring center in the Department of Pharmacology by the health-care professionals. Suspected CADR was diagnosed by the consultants concerned. The CADRs collected were categorized according to their morphology into maculopapupar rash (MPR), fixed drug eruptions (FDE), urticaria, Stevens-Johnson syndrome, and toxic epidermal necrolysis. The causality assessment was done using WHO Causality assessment scale.

Results: The mean age was 47.20 + 22.31. The most common CADR reported was Urticaria 65.5% followed MPR 23%, FDE 8.8%, and Steven Johnsons Syndrome 2.2%. Anti-microbial drugs were the most frequent cause of the adverse reactions with Amoxicillin clavulinic acid combination being the most frequent suspected drug producing CADR (13.3%). The WHO causality assessment for majority of CADR was Possible (73.5%).

Conclusion: Clinical Patterns of CADRs in this set up have some minor variations when compared to studies done across India. Amoxicillin clavulinic acid is the most common suspected drug in this study which was not frequently reported in other ADR monitoring centers.

Key words: Cutaneous Adverse Effects; Pharmacovigilance; ADR Monitoring Center; Kerala


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Shobha Parvathy
Articles by Messaline Sunitha
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

Parvathy S, Sunitha M. Pattern of cutaneous adverse drug reactions in an adverse drug monitoring center at a tertiary care hospital in Kerala. Natl J Physiol Pharm Pharmacol. 2023; 13(2): 434-437. doi:10.5455/njppp.2023.13.12610202213012023


Web Style

Parvathy S, Sunitha M. Pattern of cutaneous adverse drug reactions in an adverse drug monitoring center at a tertiary care hospital in Kerala. https://www.njppp.com/?mno=133566 [Access: March 14, 2024]. doi:10.5455/njppp.2023.13.12610202213012023


AMA (American Medical Association) Style

Parvathy S, Sunitha M. Pattern of cutaneous adverse drug reactions in an adverse drug monitoring center at a tertiary care hospital in Kerala. Natl J Physiol Pharm Pharmacol. 2023; 13(2): 434-437. doi:10.5455/njppp.2023.13.12610202213012023



Vancouver/ICMJE Style

Parvathy S, Sunitha M. Pattern of cutaneous adverse drug reactions in an adverse drug monitoring center at a tertiary care hospital in Kerala. Natl J Physiol Pharm Pharmacol. (2023), [cited March 14, 2024]; 13(2): 434-437. doi:10.5455/njppp.2023.13.12610202213012023



Harvard Style

Parvathy, S. & Sunitha, . M. (2023) Pattern of cutaneous adverse drug reactions in an adverse drug monitoring center at a tertiary care hospital in Kerala. Natl J Physiol Pharm Pharmacol, 13 (2), 434-437. doi:10.5455/njppp.2023.13.12610202213012023



Turabian Style

Parvathy, Shobha, and Messaline Sunitha. 2023. Pattern of cutaneous adverse drug reactions in an adverse drug monitoring center at a tertiary care hospital in Kerala. National Journal of Physiology, Pharmacy and Pharmacology, 13 (2), 434-437. doi:10.5455/njppp.2023.13.12610202213012023



Chicago Style

Parvathy, Shobha, and Messaline Sunitha. "Pattern of cutaneous adverse drug reactions in an adverse drug monitoring center at a tertiary care hospital in Kerala." National Journal of Physiology, Pharmacy and Pharmacology 13 (2023), 434-437. doi:10.5455/njppp.2023.13.12610202213012023



MLA (The Modern Language Association) Style

Parvathy, Shobha, and Messaline Sunitha. "Pattern of cutaneous adverse drug reactions in an adverse drug monitoring center at a tertiary care hospital in Kerala." National Journal of Physiology, Pharmacy and Pharmacology 13.2 (2023), 434-437. Print. doi:10.5455/njppp.2023.13.12610202213012023



APA (American Psychological Association) Style

Parvathy, S. & Sunitha, . M. (2023) Pattern of cutaneous adverse drug reactions in an adverse drug monitoring center at a tertiary care hospital in Kerala. National Journal of Physiology, Pharmacy and Pharmacology, 13 (2), 434-437. doi:10.5455/njppp.2023.13.12610202213012023