A retrospective and comparative study between quick sequential organ failure assessment, CURB-65, and early warning scorings in COVID-19 patients to predict the disease severity and outcome

Indranil Thakur; Ashis Kumar Ghosh; Sanat Kumar Jatua; Debdutta Haldar; Utpal Dan; Tanmay Kanti Panja

doi:10.5455/njppp.2023.13.12617202217012023

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Online Published: 02 Feb 2023

Natl J Physiol Pharm Pharmacol. 2023; 13(3): 582-588

doi: 10.5455/njppp.2023.13.12617202217012023

A retrospective and comparative study between quick sequential organ failure assessment, CURB-65, and early warning scorings in COVID-19 patients to predict the disease severity and outcome

Indranil Thakur, Ashis Kumar Ghosh, Sanat Kumar Jatua, Debdutta Haldar, Utpal Dan, Tanmay Kanti Panja.

Abstract
Background: Predicting the severity of COVID-19 infection in advance is the key to success of its treatment outcome. Various scoring systems are used to detect the severity of this disease but this study targets three simple scoring systems based on the vital parameters and basic routine laboratory tests.

Aims and Objectives: The aim of the study was to assess the predictability of three scoring systems (Quick sequential organ failure assessment [q SOFA], CURB-65, and Early Warning scoring system) for disease severity at presentation in a rural-based tertiary care center.

Materials and Methods: An observational, descriptive, retrospective, and cross-sectional study was conducted at Diamond Harbour Government Medical College Covid Hospital from January 2021 to January 2022 to assess the predictability of q SOFA, CURB-65, and Early Warning scoring system for disease severity at presentation.

Results: The total number of participants was 561 among total admitted 1367 patients. A short descriptive analysis obtained from the variables to analyze the scorings howed among total sample collected, 57% were male and 43% were female. In this study, 87% of patients were survived and the rest 13% succumbed (death). There is no statistically significant difference in mortality between both genders. Age, pulse rate, and respiratory rate have a significant correlation with the outcome and altered sensorium is also highly associated with mortality. The accuracy was also found to be little higher for National Early Warning score (NEWS) score than CURB-65 scoring and q SOFA scoring (0.919, 0.914 and 0.907). Although all the scoring systems have high sensitivity (>90%) (CURB 65: Most sensitive [0.99]), the specificities of all three scoring systems are below 50%. Among these three-scoring systems, NEWS showed the highest specificity (0.492) than q SOFA (0.423) and CURB 65 (0.394).

Conclusion: We suggest NEWS score and CURB-65 as a better predictor for in-hospital mortality in COVID-19 patients as it is significantly sensitive and reasonably specific. It can be recommended in less equipped hospitals where only basic laboratory facilities are available. qSOFA can be utilized where no laboratory facility is available like in safe home and isolation centers.

Key words: Covid-19 Disease; Quick Sequential Organ Failure Assessment; CURB-65; National Early Warning Score; Predictor

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How to Cite this Article

Pubmed Style

Thakur I, Ghosh AK, Jatua SK, Haldar D, Dan U, Panja TK. A retrospective and comparative study between quick sequential organ failure assessment, CURB-65, and early warning scorings in COVID-19 patients to predict the disease severity and outcome. Natl J Physiol Pharm Pharmacol. 2023; 13(3): 582-588.

doi:10.5455/njppp.2023.13.12617202217012023

Web Style

Thakur I, Ghosh AK, Jatua SK, Haldar D, Dan U, Panja TK. A retrospective and comparative study between quick sequential organ failure assessment, CURB-65, and early warning scorings in COVID-19 patients to predict the disease severity and outcome. https://www.njppp.com/?mno=133956 [Access: June 27, 2026].

doi:10.5455/njppp.2023.13.12617202217012023

AMA (American Medical Association) Style

Thakur I, Ghosh AK, Jatua SK, Haldar D, Dan U, Panja TK. A retrospective and comparative study between quick sequential organ failure assessment, CURB-65, and early warning scorings in COVID-19 patients to predict the disease severity and outcome. Natl J Physiol Pharm Pharmacol. 2023; 13(3): 582-588.

doi:10.5455/njppp.2023.13.12617202217012023

Vancouver/ICMJE Style

Thakur I, Ghosh AK, Jatua SK, Haldar D, Dan U, Panja TK. A retrospective and comparative study between quick sequential organ failure assessment, CURB-65, and early warning scorings in COVID-19 patients to predict the disease severity and outcome. Natl J Physiol Pharm Pharmacol. (2023), [cited June 27, 2026]; 13(3): 582-588.

doi:10.5455/njppp.2023.13.12617202217012023

Harvard Style

Thakur, I., Ghosh, . A. K., Jatua, . S. K., Haldar, . D., Dan, . U. & Panja, . T. K. (2023) A retrospective and comparative study between quick sequential organ failure assessment, CURB-65, and early warning scorings in COVID-19 patients to predict the disease severity and outcome. Natl J Physiol Pharm Pharmacol, 13 (3), 582-588.

doi:10.5455/njppp.2023.13.12617202217012023

Turabian Style

Thakur, Indranil, Ashis Kumar Ghosh, Sanat Kumar Jatua, Debdutta Haldar, Utpal Dan, and Tanmay Kanti Panja. 2023. A retrospective and comparative study between quick sequential organ failure assessment, CURB-65, and early warning scorings in COVID-19 patients to predict the disease severity and outcome. National Journal of Physiology, Pharmacy and Pharmacology, 13 (3), 582-588.

doi:10.5455/njppp.2023.13.12617202217012023

Chicago Style

Thakur, Indranil, Ashis Kumar Ghosh, Sanat Kumar Jatua, Debdutta Haldar, Utpal Dan, and Tanmay Kanti Panja. "A retrospective and comparative study between quick sequential organ failure assessment, CURB-65, and early warning scorings in COVID-19 patients to predict the disease severity and outcome." National Journal of Physiology, Pharmacy and Pharmacology 13 (2023), 582-588.

doi:10.5455/njppp.2023.13.12617202217012023

MLA (The Modern Language Association) Style

doi:10.5455/njppp.2023.13.12617202217012023

APA (American Psychological Association) Style

doi:10.5455/njppp.2023.13.12617202217012023

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