Liver function tests in patients with chronic obstructive pulmonary disease in a tertiary care hospital

Ravi Bharatkumar Thaker; Jasmin J Parmar; Rajesh M Desai; Komal Ravi Thaker

doi:10.5455/njppp.2022.12.11402202112112021

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Online Publishing Date:
20 / 11 / 2021

Natl J Physiol Pharm Pharmacol. 2022; 12(6): 727-730

doi: 10.5455/njppp.2022.12.11402202112112021

Liver function tests in patients with chronic obstructive pulmonary disease in a tertiary care hospital

Ravi Bharatkumar Thaker, Jasmin J Parmar, Rajesh M Desai, Komal Ravi Thaker.

Abstract
Background: Cases of chronic obstructive pulmonary disease (COPD) increasing day by day. Smoking is the major causative agent for COPD. The present study undertaken to estimate the deterioration of liver functions in COPD patients due to smoking.

Aims and Objectives: This study aims to investigate various liver function tests (LFTs) such as total bilirubin, alanine amino transferase/serum glutamic pyruvic transaminase (SGPT), aspartate amino transferase/SGPT, alkaline phosphatase (ALP), serum ammonia, and serum albumin among COPD patients. To correlate LFTs with forced expiratory volume at end of 1 second (FEV1) and FEV1/Forced vital capacity (FVC) ratio.

Materials and Methods: In our present study, we selected 86 cases of COPD in the age group of 4160 years. All subjects were smokers and having FEV1 <80% and FEV1/FVC <70%. A control group consists of 55 healthy individuals. LFTs were studied. FEV1 and FEV1/FVC ratio were correlated with LFTs. Statistical analysis done using SPSS software 20.0 Windows version.

Results: Mean level of SGPT among cases was 117 ± 10.23 IU/L against controls who had mean SGPT 11.16 ± 8.32 which was statistically significant (P < 0.05). Likewise, mean level of s. ammonia among cases was 154 ± 10.22 mcg/dl as compare to controls who had mean 24.43 ± 7.97 mcg/dl (P < 0.05). However, no significant difference was found in rest of the LFTs. Furthermore, there was no correlation between altered LFTs and severity of COPD.

Conclusion: LFTs are significantly altered in COPD patients due to smoking. Corticosteroids treatment must not be initiated without investigating LFTs among COPD patients.

Key words: Liver Function Tests; Chronic Obstructive Pulmonary Disease; Forced Expiratory Volume 1; Forced Expiratory Volume 1/Forced Vital Capacity

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How to Cite this Article

Pubmed Style

Thaker RB, Parmar JJ, Desai RM, Thaker KR. Liver function tests in patients with chronic obstructive pulmonary disease in a tertiary care hospital. Natl J Physiol Pharm Pharmacol. 2022; 12(6): 727-730. doi:10.5455/njppp.2022.12.11402202112112021

Web Style

Thaker RB, Parmar JJ, Desai RM, Thaker KR. Liver function tests in patients with chronic obstructive pulmonary disease in a tertiary care hospital. https://www.njppp.com/?mno=134592 [Access: March 14, 2024]. doi:10.5455/njppp.2022.12.11402202112112021

AMA (American Medical Association) Style

Thaker RB, Parmar JJ, Desai RM, Thaker KR. Liver function tests in patients with chronic obstructive pulmonary disease in a tertiary care hospital. Natl J Physiol Pharm Pharmacol. 2022; 12(6): 727-730. doi:10.5455/njppp.2022.12.11402202112112021

Vancouver/ICMJE Style

Thaker RB, Parmar JJ, Desai RM, Thaker KR. Liver function tests in patients with chronic obstructive pulmonary disease in a tertiary care hospital. Natl J Physiol Pharm Pharmacol. (2022), [cited March 14, 2024]; 12(6): 727-730. doi:10.5455/njppp.2022.12.11402202112112021

Harvard Style

Thaker, R. B., Parmar, . J. J., Desai, . R. M. & Thaker, . K. R. (2022) Liver function tests in patients with chronic obstructive pulmonary disease in a tertiary care hospital. Natl J Physiol Pharm Pharmacol, 12 (6), 727-730. doi:10.5455/njppp.2022.12.11402202112112021

Turabian Style

Thaker, Ravi Bharatkumar, Jasmin J Parmar, Rajesh M Desai, and Komal Ravi Thaker. 2022. Liver function tests in patients with chronic obstructive pulmonary disease in a tertiary care hospital. National Journal of Physiology, Pharmacy and Pharmacology, 12 (6), 727-730. doi:10.5455/njppp.2022.12.11402202112112021

Chicago Style

Thaker, Ravi Bharatkumar, Jasmin J Parmar, Rajesh M Desai, and Komal Ravi Thaker. "Liver function tests in patients with chronic obstructive pulmonary disease in a tertiary care hospital." National Journal of Physiology, Pharmacy and Pharmacology 12 (2022), 727-730. doi:10.5455/njppp.2022.12.11402202112112021

MLA (The Modern Language Association) Style

Thaker, Ravi Bharatkumar, Jasmin J Parmar, Rajesh M Desai, and Komal Ravi Thaker. "Liver function tests in patients with chronic obstructive pulmonary disease in a tertiary care hospital." National Journal of Physiology, Pharmacy and Pharmacology 12.6 (2022), 727-730. Print. doi:10.5455/njppp.2022.12.11402202112112021

APA (American Psychological Association) Style

Thaker, R. B., Parmar, . J. J., Desai, . R. M. & Thaker, . K. R. (2022) Liver function tests in patients with chronic obstructive pulmonary disease in a tertiary care hospital. National Journal of Physiology, Pharmacy and Pharmacology, 12 (6), 727-730. doi:10.5455/njppp.2022.12.11402202112112021

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