Anti-obesity and anticancer activity of Solanum xanthocarpum leaf extract: An in vitro study

Keerthana Brattiya; Remya Jagdish; Ayisha Ahamed; Anuradha C R; Jeyasudha J

doi:10.5455/njppp.2023.13.02098202323022023

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Online Publishing Date:
03 / 03 / 2023

Natl J Physiol Pharm Pharmacol. 2023; 13(4): 845-848

doi: 10.5455/njppp.2023.13.02098202323022023

Anti-obesity and anticancer activity of Solanum xanthocarpum leaf extract: An in vitro study

Keerthana Brattiya, Remya Jagdish, Ayisha Ahamed, Anuradha C R, Jeyasudha J.

Abstract
Background: Solanum xanthocarpum grows in parts of India as a wild herb. The active principles of this plant are Solasodine, Carpesterol, β-Sitosterol, and Diosgenin. Pharmacological effects such as hypoglycemic, hepatoprotective and hypotensive activity of S. xanthocarpum have been reported. Solasodine, an active component of this plant is reported to have antioxidant activity.

Aims and Objectives: The objective of this study is to evaluate the anticancer and anti-obesity property of S. xanthocarpum.

Materials and Methods: This study was carried out in Department of Pharmacology, Government Kilpauk Medical College, with laboratory support from Life Teck Research Center, Chennai. Both dry and fresh leaves of S. xanthocarpum were taken and evaluated for anticancer property using MCF cell line and anti-obesity activity using Pancreatic Lipase inhibition activity.

Results: There was significant decrease in cell viability with increase in concentration of both dry and fresh leaves which shows anticancer activity. With increase in concentrations of leaf extracts, the inhibition of pancreatic lipase was found but in comparison to Orlistat the standard treatment, the effect was very less.

Conclusion: Based on above results, it is concluded that S. xanthocarpum has good anticancer and minimal anti-obesity activity. Further investigations are required to identify the actual phytoactive component.

Key words: Solanum X-anthocarpum; Anticancer; Anti-obesity

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How to Cite this Article

Pubmed Style

Brattiya K, Jagdish R, Ahamed A, R AC, J J. Anti-obesity and anticancer activity of Solanum xanthocarpum leaf extract: An in vitro study. Natl J Physiol Pharm Pharmacol. 2023; 13(4): 845-848. doi:10.5455/njppp.2023.13.02098202323022023

Web Style

Brattiya K, Jagdish R, Ahamed A, R AC, J J. Anti-obesity and anticancer activity of Solanum xanthocarpum leaf extract: An in vitro study. https://www.njppp.com/?mno=143837 [Access: March 15, 2024]. doi:10.5455/njppp.2023.13.02098202323022023

AMA (American Medical Association) Style

Brattiya K, Jagdish R, Ahamed A, R AC, J J. Anti-obesity and anticancer activity of Solanum xanthocarpum leaf extract: An in vitro study. Natl J Physiol Pharm Pharmacol. 2023; 13(4): 845-848. doi:10.5455/njppp.2023.13.02098202323022023

Vancouver/ICMJE Style

Brattiya K, Jagdish R, Ahamed A, R AC, J J. Anti-obesity and anticancer activity of Solanum xanthocarpum leaf extract: An in vitro study. Natl J Physiol Pharm Pharmacol. (2023), [cited March 15, 2024]; 13(4): 845-848. doi:10.5455/njppp.2023.13.02098202323022023

Harvard Style

Brattiya, K., Jagdish, . R., Ahamed, . A., R, . A. C. & J, . J. (2023) Anti-obesity and anticancer activity of Solanum xanthocarpum leaf extract: An in vitro study. Natl J Physiol Pharm Pharmacol, 13 (4), 845-848. doi:10.5455/njppp.2023.13.02098202323022023

Turabian Style

Brattiya, Keerthana, Remya Jagdish, Ayisha Ahamed, Anuradha C R, and Jeyasudha J. 2023. Anti-obesity and anticancer activity of Solanum xanthocarpum leaf extract: An in vitro study. National Journal of Physiology, Pharmacy and Pharmacology, 13 (4), 845-848. doi:10.5455/njppp.2023.13.02098202323022023

Chicago Style

Brattiya, Keerthana, Remya Jagdish, Ayisha Ahamed, Anuradha C R, and Jeyasudha J. "Anti-obesity and anticancer activity of Solanum xanthocarpum leaf extract: An in vitro study." National Journal of Physiology, Pharmacy and Pharmacology 13 (2023), 845-848. doi:10.5455/njppp.2023.13.02098202323022023

MLA (The Modern Language Association) Style

Brattiya, Keerthana, Remya Jagdish, Ayisha Ahamed, Anuradha C R, and Jeyasudha J. "Anti-obesity and anticancer activity of Solanum xanthocarpum leaf extract: An in vitro study." National Journal of Physiology, Pharmacy and Pharmacology 13.4 (2023), 845-848. Print. doi:10.5455/njppp.2023.13.02098202323022023

APA (American Psychological Association) Style

Brattiya, K., Jagdish, . R., Ahamed, . A., R, . A. C. & J, . J. (2023) Anti-obesity and anticancer activity of Solanum xanthocarpum leaf extract: An in vitro study. National Journal of Physiology, Pharmacy and Pharmacology, 13 (4), 845-848. doi:10.5455/njppp.2023.13.02098202323022023

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