Antiproliferative properties of tiliroside from Guazuma ulmifolia lamk on T47D and MCF7 cancer cell lines

Muhammad Da'i; Erindyah Retno Wikantyasning; Arifah Sri Wahyuni; Ika Trisharyanti Dian Kusumawati; Azis Saifudin; Andi Suhendi

doi:10.5455/njppp.2016.6.0617727072016

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Original Research
Online Published: 08 Aug 2016

Natl J Physiol Pharm Pharmacol. 2016; 6(6): 627-633

doi: 10.5455/njppp.2016.6.0617727072016

Antiproliferative properties of tiliroside from Guazuma ulmifolia lamk on T47D and MCF7 cancer cell lines

Muhammad Da'i, Erindyah Retno Wikantyasning, Arifah Sri Wahyuni, Ika Trisharyanti Dian Kusumawati, Azis Saifudin, Andi Suhendi.

Cited By:28

Abstract
Background: Previous research showed that the extract of guazuma leaves had cytotoxic activity on various cancer cell lines. One of the chemical markers of Guazuma ulmifolia Lamk. is tiliroside.

Aims and Objectives: The aim and objective of this study was to determine the cytotoxic effects of tiliroside on T47D and MCF7 and their mechanisms.

Materials and Methods: Tiliroside (was isolated by laboratory Biological Pharmacy of Universitas Muhammadiyah Surakarta, was confirmed by using liquid chromatography-tandem mass spectrometry/MS). The antiproliferative activity was analyzed by flow cytometry and immunocytochemistry methods.

Results: Tiliroside has cytotoxic activity with inhibitory concentration 50% on T47D and MCF7 which was 67.79 and 100.00 μg/ml, respectively. Based on the immunocytochemistry, tiliroside on T47D cell lines induced apoptosis which is mediated by the activation of Caspases 8 and 9 and decreased expression of Bcl-2 protein without interference with gen protein 53 (p53). In line with the previous one, tiliroside on MCF7 cell lines induced apoptosis through extrinsic ways due to the underexpression of p53 and Caspase 9 and increase in the expression of Bcl-2 and Caspase 8.

Conclusions: The antiproliferative effects of tiliroside are higher on T47D than MCF7 cancers cell lines. Based on molecular analysis, antiproliferative mechanism was by apoptosis through extrinsic pathways.

Key words: Tiliroside; Antiproliferative; Apoptosis; MCF7; T47D

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Pubmed Style

Dai M, Wikantyasning ER, Wahyuni AS, Kusumawati ITD, Saifudin A, Suhendi A. Antiproliferative properties of tiliroside from Guazuma ulmifolia lamk on T47D and MCF7 cancer cell lines. Natl J Physiol Pharm Pharmacol. 2016; 6(6): 627-633. doi:10.5455/njppp.2016.6.0617727072016

Web Style

Dai M, Wikantyasning ER, Wahyuni AS, Kusumawati ITD, Saifudin A, Suhendi A. Antiproliferative properties of tiliroside from Guazuma ulmifolia lamk on T47D and MCF7 cancer cell lines. https://www.njppp.com/?mno=234360 [Access: June 27, 2026]. doi:10.5455/njppp.2016.6.0617727072016

AMA (American Medical Association) Style

Dai M, Wikantyasning ER, Wahyuni AS, Kusumawati ITD, Saifudin A, Suhendi A. Antiproliferative properties of tiliroside from Guazuma ulmifolia lamk on T47D and MCF7 cancer cell lines. Natl J Physiol Pharm Pharmacol. 2016; 6(6): 627-633. doi:10.5455/njppp.2016.6.0617727072016

Vancouver/ICMJE Style

Dai M, Wikantyasning ER, Wahyuni AS, Kusumawati ITD, Saifudin A, Suhendi A. Antiproliferative properties of tiliroside from Guazuma ulmifolia lamk on T47D and MCF7 cancer cell lines. Natl J Physiol Pharm Pharmacol. (2016), [cited June 27, 2026]; 6(6): 627-633. doi:10.5455/njppp.2016.6.0617727072016

Harvard Style

Dai, M., Wikantyasning, . E. R., Wahyuni, . A. S., Kusumawati, . I. T. D., Saifudin, . A. & Suhendi, . A. (2016) Antiproliferative properties of tiliroside from Guazuma ulmifolia lamk on T47D and MCF7 cancer cell lines. Natl J Physiol Pharm Pharmacol, 6 (6), 627-633. doi:10.5455/njppp.2016.6.0617727072016

Turabian Style

Dai, Muhammad, Erindyah Retno Wikantyasning, Arifah Sri Wahyuni, Ika Trisharyanti Dian Kusumawati, Azis Saifudin, and Andi Suhendi. 2016. Antiproliferative properties of tiliroside from Guazuma ulmifolia lamk on T47D and MCF7 cancer cell lines. National Journal of Physiology, Pharmacy and Pharmacology, 6 (6), 627-633. doi:10.5455/njppp.2016.6.0617727072016

Chicago Style

Dai, Muhammad, Erindyah Retno Wikantyasning, Arifah Sri Wahyuni, Ika Trisharyanti Dian Kusumawati, Azis Saifudin, and Andi Suhendi. "Antiproliferative properties of tiliroside from Guazuma ulmifolia lamk on T47D and MCF7 cancer cell lines." National Journal of Physiology, Pharmacy and Pharmacology 6 (2016), 627-633. doi:10.5455/njppp.2016.6.0617727072016

MLA (The Modern Language Association) Style

Dai, Muhammad, Erindyah Retno Wikantyasning, Arifah Sri Wahyuni, Ika Trisharyanti Dian Kusumawati, Azis Saifudin, and Andi Suhendi. "Antiproliferative properties of tiliroside from Guazuma ulmifolia lamk on T47D and MCF7 cancer cell lines." National Journal of Physiology, Pharmacy and Pharmacology 6.6 (2016), 627-633. Print. doi:10.5455/njppp.2016.6.0617727072016

APA (American Psychological Association) Style

Dai, M., Wikantyasning, . E. R., Wahyuni, . A. S., Kusumawati, . I. T. D., Saifudin, . A. & Suhendi, . A. (2016) Antiproliferative properties of tiliroside from Guazuma ulmifolia lamk on T47D and MCF7 cancer cell lines. National Journal of Physiology, Pharmacy and Pharmacology, 6 (6), 627-633. doi:10.5455/njppp.2016.6.0617727072016

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