E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research

Online Publishing Date:
29 / 08 / 2016

 


Glycosylated hemoglobin as a marker of dyslipidemia in type 2 diabetes mellitus patients in a tertiary care hospital

Dharmesh K Patel, Dharmesh N Gamit, Ankur B Patel, Binita H Gohil.


Abstract
Background: Type 2 diabetes mellitus (DM) is one of the modern pandemics. Evidence has emerged supporting the benefits of glycemic control as well as control of blood pressure and lipid levels in the prevention or delay in onset and severity of complications due to DM. Type 2 DM is a common secondary cause of dyslipidemia, in particular, if glycemic control is poor which, in turn, is an important risk factor for atherosclerosis and coronary heart disease. Glycosylated Hb (HbA1c) is a better indicator of blood glucose as compared to fasting blood glucose and postprandial blood glucose.

Aims and Objectives: (i) To know the prevalence of dyslipidemias associated with type 2 DM, (ii) To study the impact of the glycemic status on lipid profile in type 2 DM, (iii) To evaluate the efficacy of HbA1c as a marker of dyslipidemia in type 2 DM.

Material and Methods: Patients having diagnosed with Type 2 DM with no clinical evidence of coronary artery disease and more than 40 years old were enrolled in the study. A detailed history with thorough systemic examination was carried out. Hemogram, urinalysis, fasting and blood sugar after 2 h of major meal, HbA1c, lipid profile, chest X-Ray, electrocardiogram, and echocardiogram were performed.

Results: About 30% male patients and 47% female patients had HbA1c ≤8% while remaining had HbA1c >8%. 54% patients had low-density lipoprotein (LDL-C) <100 mg/dl, 18% had LDL-C between 100 and 129, and 28% had LDL-C ≥130 mg/dl. 61% male patients had LDL-C <100 mg/dl, 18% had LDL-C between 100 and 129, and 21% had LDL-C ≥130 mg/dl. 41% female patients had LDL-C <100 mg/dl, 18% had LDL-C between 100 and 129, and 41% had LDL-C ≥130 mg/dl.


Conclusion: HbA1c level showed the direct correlation with level of LDL-C, TG, and TC while it had negative correlation with high-density lipoprotein (HDL) level in the form of patients with HbA1c level >8% had higher frequency of raised LDL, raised TC, raised TG and low HDL as compared to those with HbA1c ≤8%.

Key words: Glycosylated Hb; Diabetes Mellitus; Atherosclerosis; Dyslipidemia


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Dharmesh K Patel
Articles by Dharmesh N Gamit
Articles by Ankur B Patel
Articles by Binita H Gohil
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

Dharmesh K Patel, Dharmesh N Gamit, Ankur B Patel, Binita H Gohil. Glycosylated hemoglobin as a marker of dyslipidemia in type 2 diabetes mellitus patients in a tertiary care hospital. Natl J Physiol Pharm Pharmacol. 2017; 7(1): 113-118. doi:10.5455/njppp.2017.7.088823117082016


Web Style

Dharmesh K Patel, Dharmesh N Gamit, Ankur B Patel, Binita H Gohil. Glycosylated hemoglobin as a marker of dyslipidemia in type 2 diabetes mellitus patients in a tertiary care hospital. https://www.njppp.com/?mno=239280 [Access: March 14, 2024]. doi:10.5455/njppp.2017.7.088823117082016


AMA (American Medical Association) Style

Dharmesh K Patel, Dharmesh N Gamit, Ankur B Patel, Binita H Gohil. Glycosylated hemoglobin as a marker of dyslipidemia in type 2 diabetes mellitus patients in a tertiary care hospital. Natl J Physiol Pharm Pharmacol. 2017; 7(1): 113-118. doi:10.5455/njppp.2017.7.088823117082016



Vancouver/ICMJE Style

Dharmesh K Patel, Dharmesh N Gamit, Ankur B Patel, Binita H Gohil. Glycosylated hemoglobin as a marker of dyslipidemia in type 2 diabetes mellitus patients in a tertiary care hospital. Natl J Physiol Pharm Pharmacol. (2017), [cited March 14, 2024]; 7(1): 113-118. doi:10.5455/njppp.2017.7.088823117082016



Harvard Style

Dharmesh K Patel, Dharmesh N Gamit, Ankur B Patel, Binita H Gohil (2017) Glycosylated hemoglobin as a marker of dyslipidemia in type 2 diabetes mellitus patients in a tertiary care hospital. Natl J Physiol Pharm Pharmacol, 7 (1), 113-118. doi:10.5455/njppp.2017.7.088823117082016



Turabian Style

Dharmesh K Patel, Dharmesh N Gamit, Ankur B Patel, Binita H Gohil. 2017. Glycosylated hemoglobin as a marker of dyslipidemia in type 2 diabetes mellitus patients in a tertiary care hospital. National Journal of Physiology, Pharmacy and Pharmacology, 7 (1), 113-118. doi:10.5455/njppp.2017.7.088823117082016



Chicago Style

Dharmesh K Patel, Dharmesh N Gamit, Ankur B Patel, Binita H Gohil. "Glycosylated hemoglobin as a marker of dyslipidemia in type 2 diabetes mellitus patients in a tertiary care hospital." National Journal of Physiology, Pharmacy and Pharmacology 7 (2017), 113-118. doi:10.5455/njppp.2017.7.088823117082016



MLA (The Modern Language Association) Style

Dharmesh K Patel, Dharmesh N Gamit, Ankur B Patel, Binita H Gohil. "Glycosylated hemoglobin as a marker of dyslipidemia in type 2 diabetes mellitus patients in a tertiary care hospital." National Journal of Physiology, Pharmacy and Pharmacology 7.1 (2017), 113-118. Print. doi:10.5455/njppp.2017.7.088823117082016



APA (American Psychological Association) Style

Dharmesh K Patel, Dharmesh N Gamit, Ankur B Patel, Binita H Gohil (2017) Glycosylated hemoglobin as a marker of dyslipidemia in type 2 diabetes mellitus patients in a tertiary care hospital. National Journal of Physiology, Pharmacy and Pharmacology, 7 (1), 113-118. doi:10.5455/njppp.2017.7.088823117082016