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Original Research

Online Publishing Date:
08 / 09 / 2016

 


Study of visual evoked potentials in patients with type 2 diabetes mellitus and diabetic retinopathy

Rachula Daniel, Saravanan Ayyavoo, Bagavan Dass.


Abstract
Background: Type 2 diabetes mellitus (T2DM) is a metabolic disorder showing an increasing trend with an increase in complications such as diabetic retinopathy (DR), which can cause blindness. Most patients do not notice vision loss early; hence, it is beneficial to have dysfunction of the retina identified. Patients with T2DM and DR have shown abnormalities in visually evoked potentials (VEPs).

Aims and Objectives: To investigate whether VEPs can be used to detect early changes related to T2DM and DR.

Materials and Methods: A total of 111 patients, of both sexes and aged 40-70 years, were studied as three groups of 37 each, who were, respectively, patients with T2DM, patients with DR, and controls. For all the groups, VEP recording was done using Medicaid Neurostim EP machine, and retinal examination was done using direct ophthalmoscopy. The latency and amplitude of P100 in VEP of both eyes were, respectively, analyzed using analysis of variance and posthoc test.

Results: Our results showed significantly prolonged P100 latencies of VEPs in T2DM patients and DR patients when compared to controls. However, there was no a significant difference observed in the P100 amplitudes of VEPs in T2DM patients and DR patients when compared to controls.

Conclusion: The present study has highlighted the importance of VEP as a valuable non-invasive test to detect early neuronal changes in T2DM patients and can be recommended for monitoring early effects of diabetes on visual function.

Key words: Type 2 Diabetes Mellitus; Diabetic Retinopathy; Central Nervous System; Visual Evoked Potential; P-100 Latency


 
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Pubmed Style

Rachula Daniel, Saravanan Ayyavoo, Bagavan Dass. Study of visual evoked potentials in patients with type 2 diabetes mellitus and diabetic retinopathy. Natl J Physiol Pharm Pharmacol. 2017; 7(2): 159-164. doi:10.5455/njppp.2017.7.0824424082016

Web Style

Rachula Daniel, Saravanan Ayyavoo, Bagavan Dass. Study of visual evoked potentials in patients with type 2 diabetes mellitus and diabetic retinopathy. https://www.njppp.com/?mno=239867 [Access: March 15, 2024]. doi:10.5455/njppp.2017.7.0824424082016

AMA (American Medical Association) Style

Rachula Daniel, Saravanan Ayyavoo, Bagavan Dass. Study of visual evoked potentials in patients with type 2 diabetes mellitus and diabetic retinopathy. Natl J Physiol Pharm Pharmacol. 2017; 7(2): 159-164. doi:10.5455/njppp.2017.7.0824424082016


Vancouver/ICMJE Style

Rachula Daniel, Saravanan Ayyavoo, Bagavan Dass. Study of visual evoked potentials in patients with type 2 diabetes mellitus and diabetic retinopathy. Natl J Physiol Pharm Pharmacol. (2017), [cited March 15, 2024]; 7(2): 159-164. doi:10.5455/njppp.2017.7.0824424082016


Harvard Style

Rachula Daniel, Saravanan Ayyavoo, Bagavan Dass (2017) Study of visual evoked potentials in patients with type 2 diabetes mellitus and diabetic retinopathy. Natl J Physiol Pharm Pharmacol, 7 (2), 159-164. doi:10.5455/njppp.2017.7.0824424082016


Turabian Style

Rachula Daniel, Saravanan Ayyavoo, Bagavan Dass. 2017. Study of visual evoked potentials in patients with type 2 diabetes mellitus and diabetic retinopathy. National Journal of Physiology, Pharmacy and Pharmacology, 7 (2), 159-164. doi:10.5455/njppp.2017.7.0824424082016


Chicago Style

Rachula Daniel, Saravanan Ayyavoo, Bagavan Dass. "Study of visual evoked potentials in patients with type 2 diabetes mellitus and diabetic retinopathy." National Journal of Physiology, Pharmacy and Pharmacology 7 (2017), 159-164. doi:10.5455/njppp.2017.7.0824424082016


MLA (The Modern Language Association) Style

Rachula Daniel, Saravanan Ayyavoo, Bagavan Dass. "Study of visual evoked potentials in patients with type 2 diabetes mellitus and diabetic retinopathy." National Journal of Physiology, Pharmacy and Pharmacology 7.2 (2017), 159-164. Print. doi:10.5455/njppp.2017.7.0824424082016


APA (American Psychological Association) Style

Rachula Daniel, Saravanan Ayyavoo, Bagavan Dass (2017) Study of visual evoked potentials in patients with type 2 diabetes mellitus and diabetic retinopathy. National Journal of Physiology, Pharmacy and Pharmacology, 7 (2), 159-164. doi:10.5455/njppp.2017.7.0824424082016


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