Muscle relaxant activity of hydroalcoholic extract of Mimosa pudica whole plant in mice

Parvathy Velayudhan Nair; Bindulatha Nair

doi:10.5455/njppp.2017.7.1235704012017

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Online Publishing Date:
11 / 01 / 2017

Natl J Physiol Pharm Pharmacol. 2017; 7(4): 432-437

doi: 10.5455/njppp.2017.7.1235704012017

Muscle relaxant activity of hydroalcoholic extract of Mimosa pudica whole plant in mice

Parvathy Velayudhan Nair, Bindulatha Nair.

Abstract
Background: Mimosa pudica is a traditionally used folk medicine to treat various disorders such as bleeding disorders, dysentery, piles, convulsions, rheumatoid arthritis, muscular pain, and snake bite.

Aims and Objectives: To evaluate the muscle relaxant activity of hydroalcoholic extract of M. pudica whole plant (HAEMPWP) in albino mice.

Materials and Methods: HAEMPWP was prepared using Soxhlet apparatus. Acute toxicity tests were done using the extract which was given orally to albino mice in increasing doses up to 3200 mg/kg body weight. For pharmacological study, the extract in doses of 200, 400, and 800 mg/kg was orally administered to albino mice. The muscle relaxant action was evaluated by Chimney test and Rotarod method. Data analysis was done by unpaired t-test, one-way ANOVA, Chi-square test, and log-probit analysis using SPSS software version 16.

Results: HAEMPWP showed a significant dose-dependent increase in muscle relaxant activity as compared to control.

Conclusion: HAEMPWP possesses significant muscle relaxant activity and could be an effective treatment option for various spasmodic conditions.

Key words: Mimosa pudica; Muscle Relaxant; Rotarod; Chimney Test; Soxhlet Apparatus

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Pubmed Style

Parvathy Velayudhan Nair, Bindulatha Nair. Muscle relaxant activity of hydroalcoholic extract of Mimosa pudica whole plant in mice. Natl J Physiol Pharm Pharmacol. 2017; 7(4): 432-437. doi:10.5455/njppp.2017.7.1235704012017

Web Style

Parvathy Velayudhan Nair, Bindulatha Nair. Muscle relaxant activity of hydroalcoholic extract of Mimosa pudica whole plant in mice. https://www.njppp.com/?mno=253618 [Access: March 14, 2024]. doi:10.5455/njppp.2017.7.1235704012017

AMA (American Medical Association) Style

Parvathy Velayudhan Nair, Bindulatha Nair. Muscle relaxant activity of hydroalcoholic extract of Mimosa pudica whole plant in mice. Natl J Physiol Pharm Pharmacol. 2017; 7(4): 432-437. doi:10.5455/njppp.2017.7.1235704012017

Vancouver/ICMJE Style

Parvathy Velayudhan Nair, Bindulatha Nair. Muscle relaxant activity of hydroalcoholic extract of Mimosa pudica whole plant in mice. Natl J Physiol Pharm Pharmacol. (2017), [cited March 14, 2024]; 7(4): 432-437. doi:10.5455/njppp.2017.7.1235704012017

Harvard Style

Parvathy Velayudhan Nair, Bindulatha Nair (2017) Muscle relaxant activity of hydroalcoholic extract of Mimosa pudica whole plant in mice. Natl J Physiol Pharm Pharmacol, 7 (4), 432-437. doi:10.5455/njppp.2017.7.1235704012017

Turabian Style

Parvathy Velayudhan Nair, Bindulatha Nair. 2017. Muscle relaxant activity of hydroalcoholic extract of Mimosa pudica whole plant in mice. National Journal of Physiology, Pharmacy and Pharmacology, 7 (4), 432-437. doi:10.5455/njppp.2017.7.1235704012017

Chicago Style

Parvathy Velayudhan Nair, Bindulatha Nair. "Muscle relaxant activity of hydroalcoholic extract of Mimosa pudica whole plant in mice." National Journal of Physiology, Pharmacy and Pharmacology 7 (2017), 432-437. doi:10.5455/njppp.2017.7.1235704012017

MLA (The Modern Language Association) Style

Parvathy Velayudhan Nair, Bindulatha Nair. "Muscle relaxant activity of hydroalcoholic extract of Mimosa pudica whole plant in mice." National Journal of Physiology, Pharmacy and Pharmacology 7.4 (2017), 432-437. Print. doi:10.5455/njppp.2017.7.1235704012017

APA (American Psychological Association) Style

Parvathy Velayudhan Nair, Bindulatha Nair (2017) Muscle relaxant activity of hydroalcoholic extract of Mimosa pudica whole plant in mice. National Journal of Physiology, Pharmacy and Pharmacology, 7 (4), 432-437. doi:10.5455/njppp.2017.7.1235704012017

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