Effect of Carica papaya leaf extract on platelet count in chemotherapy-induced thrombocytopenic patients: A preliminary study

Dharani Sundarmurthy; Jayanthi C R; Lakshmaiah K C

doi:10.5455/njppp.2017.7.0202628022017

2024, Vol: 14, Issue: 12

14 / 12Current Issue Online First Archive Aims and Scope Abstracting & Indexing Most Accessed Articles Most Downloaded Articles Most Cited Articles

Required files to be uploaded

NJPPP Manuscript Submission Form

« Previous Article

Original Research
Online Published: 21 Mar 2017

Natl J Physiol Pharm Pharmacol. 2017; 7(7): 685-692

doi: 10.5455/njppp.2017.7.0202628022017

Effect of Carica papaya leaf extract on platelet count in chemotherapy-induced thrombocytopenic patients: A preliminary study

Dharani Sundarmurthy, Jayanthi C R, Lakshmaiah K C.

Cited By:25

Abstract
Background: Chemotherapy-induced thrombocytopenia (CIT) is a detrimental side effect of cancer chemotherapy. Several pharmacologic agents have been evaluated, but their thrombopoietic activity is modest and often associated with unfavorable side effects. Carica papaya leaf extract (CPLE) is shown to overexpress ALOX-12 and platelet-activating factor receptor gene which stimulates the megakaryopoiesis.

Aims and Objectives: To evaluate the efficacy and safety of CPLE in CIT.

Materials and Methods: A total of 40 patients diagnosed to have CIT were randomized to two groups of 20 subjects each. Interventional group received CPLE 1100 mg TID for 7 days post chemotherapy day 7-14 and non-interventional group did not receive any active treatment. Complete hemogram was done at post chemotherapy day 7, 10, 13, and 16. Patients were followed up for 28 days for adverse effects.

Results: The mean platelet count in interventional group was 49.700 ± 12.649/mm3, which increased to 55.350 ± 15.131/mm3 (P > 0.05), 147.540 ± 54.359/mm3 (P < 0.01), and 200.585 ± 51.893/mm3 (P < 0.01) on post chemotherapy day 7, 10, 13 and 16, respectively. The mean platelet count in non-interventional group was 47.361 ± 13.110/mm3, 42.580 ± 12.108/mm3, 46.367 ± 14.776/mm3, and 54.238 ± 16.053/mm3 on post chemotherapy day 7, 10, 13, and 16, respectively, with no statistically significant improvement (ANOVA, P). Increment in white blood cell from baseline to day 7 was statistically significant (P < 0.001) as compared to control.

Conclusion: CPLE statistically increased platelet count by day 13 of post chemotherapy along with other hematological parameters. Hence, CPLE could be a viable option for treatment of CIT.

Key words: Carica papaya Leaf Extract; Chemotherapy Induced Thrombocytopenia; Platelet Count; White Blood Cell Count

	ARTICLE TOOLS
	Abstract
	PDF Fulltext
	How to cite this article
	Citation Tools
	Related Records
	Articles by Dharani Sundarmurthy Articles by Jayanthi C R Articles by Lakshmaiah K C
	on Google
	on Google Scholar

How to Cite this Article

Pubmed Style

Sundarmurthy D, R JC, C LK. Effect of Carica papaya leaf extract on platelet count in chemotherapy-induced thrombocytopenic patients: A preliminary study. Natl J Physiol Pharm Pharmacol. 2017; 7(7): 685-692. doi:10.5455/njppp.2017.7.0202628022017

Web Style

Sundarmurthy D, R JC, C LK. Effect of Carica papaya leaf extract on platelet count in chemotherapy-induced thrombocytopenic patients: A preliminary study. https://www.njppp.com/?mno=257792 [Access: January 17, 2025]. doi:10.5455/njppp.2017.7.0202628022017

AMA (American Medical Association) Style

Sundarmurthy D, R JC, C LK. Effect of Carica papaya leaf extract on platelet count in chemotherapy-induced thrombocytopenic patients: A preliminary study. Natl J Physiol Pharm Pharmacol. 2017; 7(7): 685-692. doi:10.5455/njppp.2017.7.0202628022017

Vancouver/ICMJE Style

Sundarmurthy D, R JC, C LK. Effect of Carica papaya leaf extract on platelet count in chemotherapy-induced thrombocytopenic patients: A preliminary study. Natl J Physiol Pharm Pharmacol. (2017), [cited January 17, 2025]; 7(7): 685-692. doi:10.5455/njppp.2017.7.0202628022017

Harvard Style

Sundarmurthy, D., R, . J. C. & C, . L. K. (2017) Effect of Carica papaya leaf extract on platelet count in chemotherapy-induced thrombocytopenic patients: A preliminary study. Natl J Physiol Pharm Pharmacol, 7 (7), 685-692. doi:10.5455/njppp.2017.7.0202628022017

Turabian Style

Sundarmurthy, Dharani, Jayanthi C R, and Lakshmaiah K C. 2017. Effect of Carica papaya leaf extract on platelet count in chemotherapy-induced thrombocytopenic patients: A preliminary study. National Journal of Physiology, Pharmacy and Pharmacology, 7 (7), 685-692. doi:10.5455/njppp.2017.7.0202628022017

Chicago Style

Sundarmurthy, Dharani, Jayanthi C R, and Lakshmaiah K C. "Effect of Carica papaya leaf extract on platelet count in chemotherapy-induced thrombocytopenic patients: A preliminary study." National Journal of Physiology, Pharmacy and Pharmacology 7 (2017), 685-692. doi:10.5455/njppp.2017.7.0202628022017

MLA (The Modern Language Association) Style

Sundarmurthy, Dharani, Jayanthi C R, and Lakshmaiah K C. "Effect of Carica papaya leaf extract on platelet count in chemotherapy-induced thrombocytopenic patients: A preliminary study." National Journal of Physiology, Pharmacy and Pharmacology 7.7 (2017), 685-692. Print. doi:10.5455/njppp.2017.7.0202628022017

APA (American Psychological Association) Style

Sundarmurthy, D., R, . J. C. & C, . L. K. (2017) Effect of Carica papaya leaf extract on platelet count in chemotherapy-induced thrombocytopenic patients: A preliminary study. National Journal of Physiology, Pharmacy and Pharmacology, 7 (7), 685-692. doi:10.5455/njppp.2017.7.0202628022017

Author Login Reviewer Login About Publisher Editorial Policies Editorial Review Policy Peer Review Policy Editorial & Peer Review Process Publication Ethics and Publication Malpractice Statement Conflict of Interest Policy Plagiarism Policy Protection of Research Participants (Statement On Human And Animal Rights)Corrections, Retractions & Expressions of Concern Self-Archiving Policies Digital Archiving & Preservation Policies Statement of Informed Consent Advertising Policy Terms of Use License Information Copyright Information

About National Journal of Physiology, Pharmacy and Pharmacology

Contact Information

How to cite this article