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Case Report
Online Published: 15 Jul 2017
 


Arsenic trioxide-induced QT interval prolongation: A case report

Devika Mohan, Raghuveer Prabhu, Remya Reghu.


Cited By:5

Abstract
QT prolongation refers to the prolonged QT interval in electrocardiography (ECG) which can even lead to life-threatening events such as ventricular arrhythmias, torsades de pointes, etc., several drugs can cause QT prolongation which includes sotalol, quinidine, arsenic, disopyramide, procainamide, amiodarone, haloperidol, etc., Arsenic trioxide (ATO) is used as an effective treatment option in promyelocytic leukemia (PML). Acute myeloid leukemia (AML) is a cancer that affects the blood and bone marrow. Acute promyelocytic leukemia (APL) is the M3 subtype of AML that affects mainly the white blood cells. In APL, immature granulocytes accumulate abnormally to form promyelocytes. ATO helps in the apoptosis of these cancerous promyelocytic cells. In patients on arsenic therapy, ECGs must be monitored to ensure QT prolongation as it a major side effect of the drug. Here is the case of a 58-year-old female patient and was newly diagnosed with APL. She developed QT prolongation with arsenic therapy. Other confounding factors such as electrolytes and presence of other QT-prolonging drugs were also corrected.

Key words: Acute Promyelocytic Leukemia; Promyelocytes; QT Prolongation; Torsades De Pointes; Arsenic Trioxide


 
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How to Cite this Article
Pubmed Style

Mohan D, Prabhu R, Reghu R. Arsenic trioxide-induced QT interval prolongation: A case report. Natl J Physiol Pharm Pharmacol. 2017; 7(8): 878-880. doi:10.5455/njppp.2017.7.0621330062017

Web Style

Mohan D, Prabhu R, Reghu R. Arsenic trioxide-induced QT interval prolongation: A case report. https://www.njppp.com/?mno=270206 [Access: June 27, 2026]. doi:10.5455/njppp.2017.7.0621330062017

AMA (American Medical Association) Style

Mohan D, Prabhu R, Reghu R. Arsenic trioxide-induced QT interval prolongation: A case report. Natl J Physiol Pharm Pharmacol. 2017; 7(8): 878-880. doi:10.5455/njppp.2017.7.0621330062017


Vancouver/ICMJE Style

Mohan D, Prabhu R, Reghu R. Arsenic trioxide-induced QT interval prolongation: A case report. Natl J Physiol Pharm Pharmacol. (2017), [cited June 27, 2026]; 7(8): 878-880. doi:10.5455/njppp.2017.7.0621330062017


Harvard Style

Mohan, D., Prabhu, . R. & Reghu, . R. (2017) Arsenic trioxide-induced QT interval prolongation: A case report. Natl J Physiol Pharm Pharmacol, 7 (8), 878-880. doi:10.5455/njppp.2017.7.0621330062017


Turabian Style

Mohan, Devika, Raghuveer Prabhu, and Remya Reghu. 2017. Arsenic trioxide-induced QT interval prolongation: A case report. National Journal of Physiology, Pharmacy and Pharmacology, 7 (8), 878-880. doi:10.5455/njppp.2017.7.0621330062017


Chicago Style

Mohan, Devika, Raghuveer Prabhu, and Remya Reghu. "Arsenic trioxide-induced QT interval prolongation: A case report." National Journal of Physiology, Pharmacy and Pharmacology 7 (2017), 878-880. doi:10.5455/njppp.2017.7.0621330062017


MLA (The Modern Language Association) Style

Mohan, Devika, Raghuveer Prabhu, and Remya Reghu. "Arsenic trioxide-induced QT interval prolongation: A case report." National Journal of Physiology, Pharmacy and Pharmacology 7.8 (2017), 878-880. Print. doi:10.5455/njppp.2017.7.0621330062017


APA (American Psychological Association) Style

Mohan, D., Prabhu, . R. & Reghu, . R. (2017) Arsenic trioxide-induced QT interval prolongation: A case report. National Journal of Physiology, Pharmacy and Pharmacology, 7 (8), 878-880. doi:10.5455/njppp.2017.7.0621330062017


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