Antidiabetic effects of Cycas riuminiana leaf extracts on alloxan-induced diabetic ICR mice (Mus musculus L.)

Jose Lorenzo M Barroso; Danalou Claudine G Lacanilao; Renz Anthony C Sac; Rodel Jonathan S Vitor II

doi:10.5455/njppp.2017.7.0831714092017

2026, Vol: 16, Issue: 1

16 / 1Current Issue Online First Archive Aims and Scope Abstracting & Indexing Most Accessed Articles Most Downloaded Articles Most Cited Articles

Required files to be uploaded

NJPPP Manuscript Submission Form
Title Page

« Previous Article

Original Research
Online Published: 27 Sep 2017

Natl J Physiol Pharm Pharmacol. 2017; 7(12): 1390-1396

doi: 10.5455/njppp.2017.7.0831714092017

Antidiabetic effects of Cycas riuminiana leaf extracts on alloxan-induced diabetic ICR mice (Mus musculus L.)

Jose Lorenzo M Barroso, Danalou Claudine G Lacanilao, Renz Anthony C Sac, Rodel Jonathan S Vitor Ii.

Cited By:4

Abstract
Background: The Philippines is one of the countries with high prevalence of diabetes mellitus. Although there are several drugs marketed to control it, there are unwanted side effects. Knowing this, alternative options have been sought for to control the disease.

Aims and Objectives: To evaluate the effects of aqueous extracts of Cycas riuminiana on the blood glucose and cholesterol levels of alloxan-induced diabetic mice.

Materials and Methods: Aqueous crude leaf extract from C. riuminiana was administered to 6 and 30 ICR mice (Mus musculus) to determine whether there are toxic effects and effects on the blood glucose and cholesterol levels, respectively. The 30 mice were divided into six groups and were either treated with double distilled water, glimepiride, or the C. riuminiana aqueous extract.

Results: After performing the acute oral toxicity, there were no deaths signifying that the extracts may be safe to administer in mice. After 28 days of treatment, statistical analyses indicated that the treatment groups had anti-hyperglycemic effects on the diabetic mice. The high-dose group had the lowest mean blood glucose values, which surpassed the hypoglycemic effects of the positive control group, which was treated with glimepiride. Furthermore, there was no difference between the control and the treatment groups. On the other hand, blood cholesterol values of the treatment and control groups were within the normal range after the 28 days study.

Conclusion: The results of the study shows that C. riuminiana leaves have antidiabetic properties by lowering glucose and cholesterol levels at doses between 250 and 1000 mg/kg body weight.

Key words: Anticholesteremic; Blood Glucose; Cycas riuminiana; Hemtatology; Hypoglycemic Agents; Mus musculus

	ARTICLE TOOLS
	Abstract
	PDF Fulltext
	How to cite this article
	Citation Tools
	Related Records
	Articles by Jose Lorenzo M Barroso Articles by Danalou Claudine G Lacanilao Articles by Renz Anthony C Sac Articles by Rodel Jonathan S Vitor II
	on Google
	on Google Scholar

How to Cite this Article

Pubmed Style

Barroso JLM, Lacanilao DCG, Sac RAC, Ii RJSV. Antidiabetic effects of Cycas riuminiana leaf extracts on alloxan-induced diabetic ICR mice (Mus musculus L.). Natl J Physiol Pharm Pharmacol. 2017; 7(12): 1390-1396. doi:10.5455/njppp.2017.7.0831714092017

Web Style

Barroso JLM, Lacanilao DCG, Sac RAC, Ii RJSV. Antidiabetic effects of Cycas riuminiana leaf extracts on alloxan-induced diabetic ICR mice (Mus musculus L.). https://www.njppp.com/?mno=275162 [Access: June 27, 2026]. doi:10.5455/njppp.2017.7.0831714092017

AMA (American Medical Association) Style

Barroso JLM, Lacanilao DCG, Sac RAC, Ii RJSV. Antidiabetic effects of Cycas riuminiana leaf extracts on alloxan-induced diabetic ICR mice (Mus musculus L.). Natl J Physiol Pharm Pharmacol. 2017; 7(12): 1390-1396. doi:10.5455/njppp.2017.7.0831714092017

Vancouver/ICMJE Style

Barroso JLM, Lacanilao DCG, Sac RAC, Ii RJSV. Antidiabetic effects of Cycas riuminiana leaf extracts on alloxan-induced diabetic ICR mice (Mus musculus L.). Natl J Physiol Pharm Pharmacol. (2017), [cited June 27, 2026]; 7(12): 1390-1396. doi:10.5455/njppp.2017.7.0831714092017

Harvard Style

Barroso, J. L. M., Lacanilao, . D. C. G., Sac, . R. A. C. & Ii, . R. J. S. V. (2017) Antidiabetic effects of Cycas riuminiana leaf extracts on alloxan-induced diabetic ICR mice (Mus musculus L.). Natl J Physiol Pharm Pharmacol, 7 (12), 1390-1396. doi:10.5455/njppp.2017.7.0831714092017

Turabian Style

Barroso, Jose Lorenzo M, Danalou Claudine G Lacanilao, Renz Anthony C Sac, and Rodel Jonathan S Vitor Ii. 2017. Antidiabetic effects of Cycas riuminiana leaf extracts on alloxan-induced diabetic ICR mice (Mus musculus L.). National Journal of Physiology, Pharmacy and Pharmacology, 7 (12), 1390-1396. doi:10.5455/njppp.2017.7.0831714092017

Chicago Style

Barroso, Jose Lorenzo M, Danalou Claudine G Lacanilao, Renz Anthony C Sac, and Rodel Jonathan S Vitor Ii. "Antidiabetic effects of Cycas riuminiana leaf extracts on alloxan-induced diabetic ICR mice (Mus musculus L.)." National Journal of Physiology, Pharmacy and Pharmacology 7 (2017), 1390-1396. doi:10.5455/njppp.2017.7.0831714092017

MLA (The Modern Language Association) Style

Barroso, Jose Lorenzo M, Danalou Claudine G Lacanilao, Renz Anthony C Sac, and Rodel Jonathan S Vitor Ii. "Antidiabetic effects of Cycas riuminiana leaf extracts on alloxan-induced diabetic ICR mice (Mus musculus L.)." National Journal of Physiology, Pharmacy and Pharmacology 7.12 (2017), 1390-1396. Print. doi:10.5455/njppp.2017.7.0831714092017

APA (American Psychological Association) Style

Barroso, J. L. M., Lacanilao, . D. C. G., Sac, . R. A. C. & Ii, . R. J. S. V. (2017) Antidiabetic effects of Cycas riuminiana leaf extracts on alloxan-induced diabetic ICR mice (Mus musculus L.). National Journal of Physiology, Pharmacy and Pharmacology, 7 (12), 1390-1396. doi:10.5455/njppp.2017.7.0831714092017

About National Journal of Physiology, Pharmacy and Pharmacology

Contact Information

How to cite this article