Evaluation of the analgesic activity of an aqueous extract of the seeds of Nigella sativa Linn in albino rats

Rameez Ahmed; Sameer Uz Zaman; Mohammed Waseem Ahmed

doi:10.5455/njppp.2021.11.11311202001912020

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25 / 11 / 2020

Natl J Physiol Pharm Pharmacol. 2021; 11(3): 288-291

doi: 10.5455/njppp.2021.11.11311202001912020

Evaluation of the analgesic activity of an aqueous extract of the seeds of Nigella sativa Linn in albino rats

Rameez Ahmed, Sameer Uz Zaman, Mohammed Waseem Ahmed.

Abstract
Background: Many herbs and plant products have been claimed to have a significant analgesic action. However, not much work has been reported on the pharmacological evaluation of such plant-based products for the analgesic effects claimed in traditional medicine.

Aim and Objective: The study aimed to assess the analgesic potential of the aqueous extract of Nigella sativa Linn (NSL) in albino rats by the hot plate and tail-flick method and to compare it with the standard drug indomethacin.

Materials and Methods: Four groups of randomly divided albino rats were made. Group 1 was given oral normal saline (0.1 mg/kg) (control group). Group 2 was given indomethacin 25 mg/kg orally (standard group). Groups 3 and 4 (test groups) were administered NSL 300 mg/kg body weight (BW) and 600 mg/kg BW orally, respectively. The hot plate and tail-flick method were used to screen for analgesic potential.

Results: Our study revealed a uniform increase in reaction time in both test groups which received NSL. Maximum analgesic activity was noted at 120 min. NSL has good analgesic activity in comparison with the control. However, indomethacin has significantly better activity than NSL at both doses. NSL at 600 mg/kg BW has analgesic activity comparable to indomethacin only at 20 min.

Conclusion: NSL has analgesic potential, but comparatively, indomethacin is a more potent analgesic drug.

Key words: Nigella sativa Linn; Albino Rats; Indomethacin; Analgesic

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Pubmed Style

Ahmed R, Zaman SU, Ahmed MW. Evaluation of the analgesic activity of an aqueous extract of the seeds of Nigella sativa Linn in albino rats. Natl J Physiol Pharm Pharmacol. 2021; 11(3): 288-291. doi:10.5455/njppp.2021.11.11311202001912020

Web Style

Ahmed R, Zaman SU, Ahmed MW. Evaluation of the analgesic activity of an aqueous extract of the seeds of Nigella sativa Linn in albino rats. https://www.njppp.com/?mno=29389 [Access: March 14, 2024]. doi:10.5455/njppp.2021.11.11311202001912020

AMA (American Medical Association) Style

Ahmed R, Zaman SU, Ahmed MW. Evaluation of the analgesic activity of an aqueous extract of the seeds of Nigella sativa Linn in albino rats. Natl J Physiol Pharm Pharmacol. 2021; 11(3): 288-291. doi:10.5455/njppp.2021.11.11311202001912020

Vancouver/ICMJE Style

Ahmed R, Zaman SU, Ahmed MW. Evaluation of the analgesic activity of an aqueous extract of the seeds of Nigella sativa Linn in albino rats. Natl J Physiol Pharm Pharmacol. (2021), [cited March 14, 2024]; 11(3): 288-291. doi:10.5455/njppp.2021.11.11311202001912020

Harvard Style

Ahmed, R., Zaman, . S. U. & Ahmed, . M. W. (2021) Evaluation of the analgesic activity of an aqueous extract of the seeds of Nigella sativa Linn in albino rats. Natl J Physiol Pharm Pharmacol, 11 (3), 288-291. doi:10.5455/njppp.2021.11.11311202001912020

Turabian Style

Ahmed, Rameez, Sameer Uz Zaman, and Mohammed Waseem Ahmed. 2021. Evaluation of the analgesic activity of an aqueous extract of the seeds of Nigella sativa Linn in albino rats. National Journal of Physiology, Pharmacy and Pharmacology, 11 (3), 288-291. doi:10.5455/njppp.2021.11.11311202001912020

Chicago Style

Ahmed, Rameez, Sameer Uz Zaman, and Mohammed Waseem Ahmed. "Evaluation of the analgesic activity of an aqueous extract of the seeds of Nigella sativa Linn in albino rats." National Journal of Physiology, Pharmacy and Pharmacology 11 (2021), 288-291. doi:10.5455/njppp.2021.11.11311202001912020

MLA (The Modern Language Association) Style

Ahmed, Rameez, Sameer Uz Zaman, and Mohammed Waseem Ahmed. "Evaluation of the analgesic activity of an aqueous extract of the seeds of Nigella sativa Linn in albino rats." National Journal of Physiology, Pharmacy and Pharmacology 11.3 (2021), 288-291. Print. doi:10.5455/njppp.2021.11.11311202001912020

APA (American Psychological Association) Style

Ahmed, R., Zaman, . S. U. & Ahmed, . M. W. (2021) Evaluation of the analgesic activity of an aqueous extract of the seeds of Nigella sativa Linn in albino rats. National Journal of Physiology, Pharmacy and Pharmacology, 11 (3), 288-291. doi:10.5455/njppp.2021.11.11311202001912020

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