Effects of soy isoflavone genistein on lipid profile and hepatic steatosis in high-fat-fed Wistar rats

Deepa Kameswari Perumal; Mangaiarkkarasi Adhimoolam; Erli Amel Ivan; Meher Ali Rajamohammed

doi:10.5455/njppp.2019.9.0621617062019

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Original Research
Online Published: 25 Jun 2019

Natl J Physiol Pharm Pharmacol. 2019; 9(9): 856-861

doi: 10.5455/njppp.2019.9.0621617062019

Effects of soy isoflavone genistein on lipid profile and hepatic steatosis in high-fat-fed Wistar rats

Deepa Kameswari Perumal, Mangaiarkkarasi Adhimoolam, Erli Amel Ivan, Meher Ali Rajamohammed.

Cited By:6

Abstract
Background: Hyperlipidemia is a major cause of atherosclerosis-induced conditions such as coronary heart disease, ischemic cerebrovascular disease, and peripheral vascular disease. Due to various adverse effects with the current pharmacological therapy, many plant-derived compounds are being tested to lower serum lipid levels. Genistein, a soy isoflavone, showed promising results in several studies.

Aims and Objectives: The study aimed to evaluate the effectiveness of genistein on serum lipid profile and its hepatoprotective activity in hyperlipidemic male albino Wistar rats.

Materials and Methods: Thirty-six male Wistar rats were randomly divided into six groups. Animals were given high cholesterol diet (0.75% cholesterol + 1.5% bile salt) to induce hyperlipidemia. The animals were treated with atorvastatin (10 mg/kg oral) and genistein (1 mg/kg oral and 5 mg/kg oral) once daily for a period of 30 days. Blood samples were collected for biochemical analysis of lipoproteins and a portion of liver tissue was taken for histopathological examination. Statistical analysis was performed by one-way analysis of variance test followed by post hoc Dunnetts multiple comparison test. P < 0.05 was considered statistically significant.

Results: Oral administration of genistein showed a significant reduction in serum total cholesterol, triglycerides, and low-density lipoprotein levels. Histopathological examination of liver showed a significant reduction in hepatic steatosis (P < 0.001) with no inflammatory changes as compared to high cholesterol-treated rats.

Conclusion: The present study demonstrated significant hypolipidemic and hepatoprotective activities of genistein at a dose of 5 mg/kg in the experimental rats.

Key words: Genistein; Hypolipidemia; Hepatic Steatosis; High-fat Diet

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How to Cite this Article

Pubmed Style

Perumal DK, Adhimoolam M, Ivan EA, Rajamohammed MA. Effects of soy isoflavone genistein on lipid profile and hepatic steatosis in high-fat-fed Wistar rats. Natl J Physiol Pharm Pharmacol. 2019; 9(9): 856-861.

doi:10.5455/njppp.2019.9.0621617062019

Web Style

Perumal DK, Adhimoolam M, Ivan EA, Rajamohammed MA. Effects of soy isoflavone genistein on lipid profile and hepatic steatosis in high-fat-fed Wistar rats. https://www.njppp.com/?mno=52499 [Access: June 26, 2026].

doi:10.5455/njppp.2019.9.0621617062019

AMA (American Medical Association) Style

Perumal DK, Adhimoolam M, Ivan EA, Rajamohammed MA. Effects of soy isoflavone genistein on lipid profile and hepatic steatosis in high-fat-fed Wistar rats. Natl J Physiol Pharm Pharmacol. 2019; 9(9): 856-861.

doi:10.5455/njppp.2019.9.0621617062019

Vancouver/ICMJE Style

Perumal DK, Adhimoolam M, Ivan EA, Rajamohammed MA. Effects of soy isoflavone genistein on lipid profile and hepatic steatosis in high-fat-fed Wistar rats. Natl J Physiol Pharm Pharmacol. (2019), [cited June 26, 2026]; 9(9): 856-861.

doi:10.5455/njppp.2019.9.0621617062019

Harvard Style

Perumal, D. K., Adhimoolam, . M., Ivan, . E. A. & Rajamohammed, . M. A. (2019) Effects of soy isoflavone genistein on lipid profile and hepatic steatosis in high-fat-fed Wistar rats. Natl J Physiol Pharm Pharmacol, 9 (9), 856-861.

doi:10.5455/njppp.2019.9.0621617062019

Turabian Style

Perumal, Deepa Kameswari, Mangaiarkkarasi Adhimoolam, Erli Amel Ivan, and Meher Ali Rajamohammed. 2019. Effects of soy isoflavone genistein on lipid profile and hepatic steatosis in high-fat-fed Wistar rats. National Journal of Physiology, Pharmacy and Pharmacology, 9 (9), 856-861.

doi:10.5455/njppp.2019.9.0621617062019

Chicago Style

Perumal, Deepa Kameswari, Mangaiarkkarasi Adhimoolam, Erli Amel Ivan, and Meher Ali Rajamohammed. "Effects of soy isoflavone genistein on lipid profile and hepatic steatosis in high-fat-fed Wistar rats." National Journal of Physiology, Pharmacy and Pharmacology 9 (2019), 856-861.

doi:10.5455/njppp.2019.9.0621617062019

MLA (The Modern Language Association) Style

doi:10.5455/njppp.2019.9.0621617062019

APA (American Psychological Association) Style

doi:10.5455/njppp.2019.9.0621617062019

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