The antidepressant activity of the alcoholic extract of Withania coagulans fruits in Swiss albino mice by forced swimming test

Amit S Kamdi; Pankaj N Bohra; Suvarna M Kalambe; Ajay R Chandrakapure

doi:10.5455/njppp.2019.9.0622502072019

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Online Published: 16 Jul 2019

Natl J Physiol Pharm Pharmacol. 2019; 9(9): 904-906

doi: 10.5455/njppp.2019.9.0622502072019

The antidepressant activity of the alcoholic extract of Withania coagulans fruits in Swiss albino mice by forced swimming test

Amit S Kamdi, Pankaj N Bohra, Suvarna M Kalambe, Ajay R Chandrakapure.

Cited By:2

Abstract
Background: Depression is one of the most upsetting mood disorders. The various antidepressant medications used today are having the adverse drug effects. Withania coagulans a vulnerable species, is not explored much for its effects on mood except in the late 70s. Therefore, it was thought worthy to explore anti-depressive activities of the alcoholic extract of W. coagulans fruits in Swiss albino mice using forced swimming test.

Aims and Objectives: This study aims to study the antidepressant activities of the alcoholic extract of W. coagulans fruits in Swiss albino mice using forced swimming test.

Materials and Methods: Forced swimming test was used for assessing the anti-depressive activity of W. coagulans fruits alcoholic extract. If the extract had antidepressant activity, then it was expected that the period of mobility would increase and immobility would decrease. This decrease in immobility, if found statistically significant, was considered for antidepressant activity.

Results: There was statistically highly significant (P < 0.001) association observed between alcoholic extract of W. coagulans fruits with depressive effect on mood in Swiss albino mice.

Conclusion: The alcoholic extract of W. coagulans fruits did not demonstrate antidepressant activity in Swiss albino mice. In contrast, it revealed depressive effect on the mood in the forced swimming test.

Key words: Antidepressant; Swiss Albino Mice; Alcoholic Extract; Withania coagulans; Forced Swimming Test

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Pubmed Style

Kamdi AS, Bohra PN, Kalambe SM, Chandrakapure AR. The antidepressant activity of the alcoholic extract of Withania coagulans fruits in Swiss albino mice by forced swimming test. Natl J Physiol Pharm Pharmacol. 2019; 9(9): 904-906.

doi:10.5455/njppp.2019.9.0622502072019

Web Style

Kamdi AS, Bohra PN, Kalambe SM, Chandrakapure AR. The antidepressant activity of the alcoholic extract of Withania coagulans fruits in Swiss albino mice by forced swimming test. https://www.njppp.com/?mno=53912 [Access: June 26, 2026].

doi:10.5455/njppp.2019.9.0622502072019

AMA (American Medical Association) Style

Kamdi AS, Bohra PN, Kalambe SM, Chandrakapure AR. The antidepressant activity of the alcoholic extract of Withania coagulans fruits in Swiss albino mice by forced swimming test. Natl J Physiol Pharm Pharmacol. 2019; 9(9): 904-906.

doi:10.5455/njppp.2019.9.0622502072019

Vancouver/ICMJE Style

Kamdi AS, Bohra PN, Kalambe SM, Chandrakapure AR. The antidepressant activity of the alcoholic extract of Withania coagulans fruits in Swiss albino mice by forced swimming test. Natl J Physiol Pharm Pharmacol. (2019), [cited June 26, 2026]; 9(9): 904-906.

doi:10.5455/njppp.2019.9.0622502072019

Harvard Style

Kamdi, A. S., Bohra, . P. N., Kalambe, . S. M. & Chandrakapure, . A. R. (2019) The antidepressant activity of the alcoholic extract of Withania coagulans fruits in Swiss albino mice by forced swimming test. Natl J Physiol Pharm Pharmacol, 9 (9), 904-906.

doi:10.5455/njppp.2019.9.0622502072019

Turabian Style

Kamdi, Amit S, Pankaj N Bohra, Suvarna M Kalambe, and Ajay R Chandrakapure. 2019. The antidepressant activity of the alcoholic extract of Withania coagulans fruits in Swiss albino mice by forced swimming test. National Journal of Physiology, Pharmacy and Pharmacology, 9 (9), 904-906.

doi:10.5455/njppp.2019.9.0622502072019

Chicago Style

Kamdi, Amit S, Pankaj N Bohra, Suvarna M Kalambe, and Ajay R Chandrakapure. "The antidepressant activity of the alcoholic extract of Withania coagulans fruits in Swiss albino mice by forced swimming test." National Journal of Physiology, Pharmacy and Pharmacology 9 (2019), 904-906.

doi:10.5455/njppp.2019.9.0622502072019

MLA (The Modern Language Association) Style

doi:10.5455/njppp.2019.9.0622502072019

APA (American Psychological Association) Style

doi:10.5455/njppp.2019.9.0622502072019

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