Influence of coadministration of metformin and methanolic stem extract of Anisopus mannii N.E.Br. (Apocynaceae) on glucose homeostasis and lipid profile in streptozotocin/nicotinamide-induced diabetic rats

Aminu Chika; Amina Yahaya; Abubakar Amali Muhammad; Muhammad Bashiru Abdulrahman

doi:10.5455/njppp.2019.9.0931023092019001

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Online Published: 03 Oct 2019

Natl J Physiol Pharm Pharmacol. 2019; 9(11): 1145-1151

doi: 10.5455/njppp.2019.9.0931023092019001

Influence of coadministration of metformin and methanolic stem extract of Anisopus mannii N.E.Br. (Apocynaceae) on glucose homeostasis and lipid profile in streptozotocin/nicotinamide-induced diabetic rats

Aminu Chika, Amina Yahaya, Abubakar Amali Muhammad, Muhammad Bashiru Abdulrahman.

Cited By:4

Abstract
Background: Anisopus mannii (AM) N.E.Br. (Apocynaceae), a plant traditionally used for the treatment of diabetes mellitus in Northwestern Nigeria, is often prescribed as an adjunct to conventional treatment of diabetes mellitus.

Aims and Objectives: The objective was to investigate the influence of coadministration of the stem of AM and metformin on glucose homeostasis and lipid profile in rats.

Materials and Methods: Following departmental ethics committee permission, two doses (200 mg/kg and 600 mg/kg) each of the aqueous and methanolic stem extracts of AM were administered to glucose-loaded normal rats, and the influence of the co-administration of the most effective of the doses tested (200 mg/kg of methanolic stem extract) with metformin (50 mg/kg) for 28 days on glucose homeostasis and lipid profile was investigated in streptozotocin/nicotinamide-induced diabetic rats.

Results: When coadministered, metformin reduced the fasting glucose-lowering effect of the AM extract, whereas the extract reduced the degree of elevation of the skeletal muscle glycogen content by metformin. Furthermore, both the extract and metformin, when combined in diabetic rats, reduced each others beneficial effects in (a) improving glucose tolerance, as evidenced by reduction in the total area under the oral glucose tolerance test curve; (b) reducing fasting blood levels of total cholesterol, low-density lipoprotein cholesterol and triglycerides; and (c) increasing hepatic glycogen content.

Conclusion: This study revealed that metformin (50 mg/kg) and the methanolic stem extract of AM (200 mg/kg) had a potentially negative influence on each others beneficial effects on glucose homeostasis and lipid profile in diabetic rats.

Key words: Anisopus mannii; Metformin; Streptozotocin; Diabetic Rats; Coadministration

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Pubmed Style

Chika A, Yahaya A, Muhammad AA, Abdulrahman MB. Influence of coadministration of metformin and methanolic stem extract of Anisopus mannii N.E.Br. (Apocynaceae) on glucose homeostasis and lipid profile in streptozotocin/nicotinamide-induced diabetic rats. Natl J Physiol Pharm Pharmacol. 2019; 9(11): 1145-1151.

doi:10.5455/njppp.2019.9.0931023092019001

Web Style

Chika A, Yahaya A, Muhammad AA, Abdulrahman MB. Influence of coadministration of metformin and methanolic stem extract of Anisopus mannii N.E.Br. (Apocynaceae) on glucose homeostasis and lipid profile in streptozotocin/nicotinamide-induced diabetic rats. https://www.njppp.com/?mno=64963 [Access: June 27, 2026].

doi:10.5455/njppp.2019.9.0931023092019001

AMA (American Medical Association) Style

Chika A, Yahaya A, Muhammad AA, Abdulrahman MB. Influence of coadministration of metformin and methanolic stem extract of Anisopus mannii N.E.Br. (Apocynaceae) on glucose homeostasis and lipid profile in streptozotocin/nicotinamide-induced diabetic rats. Natl J Physiol Pharm Pharmacol. 2019; 9(11): 1145-1151.

doi:10.5455/njppp.2019.9.0931023092019001

Vancouver/ICMJE Style

Chika A, Yahaya A, Muhammad AA, Abdulrahman MB. Influence of coadministration of metformin and methanolic stem extract of Anisopus mannii N.E.Br. (Apocynaceae) on glucose homeostasis and lipid profile in streptozotocin/nicotinamide-induced diabetic rats. Natl J Physiol Pharm Pharmacol. (2019), [cited June 27, 2026]; 9(11): 1145-1151.

doi:10.5455/njppp.2019.9.0931023092019001

Harvard Style

Chika, A., Yahaya, . A., Muhammad, . A. A. & Abdulrahman, . M. B. (2019) Influence of coadministration of metformin and methanolic stem extract of Anisopus mannii N.E.Br. (Apocynaceae) on glucose homeostasis and lipid profile in streptozotocin/nicotinamide-induced diabetic rats. Natl J Physiol Pharm Pharmacol, 9 (11), 1145-1151.

doi:10.5455/njppp.2019.9.0931023092019001

Turabian Style

Chika, Aminu, Amina Yahaya, Abubakar Amali Muhammad, and Muhammad Bashiru Abdulrahman. 2019. Influence of coadministration of metformin and methanolic stem extract of Anisopus mannii N.E.Br. (Apocynaceae) on glucose homeostasis and lipid profile in streptozotocin/nicotinamide-induced diabetic rats. National Journal of Physiology, Pharmacy and Pharmacology, 9 (11), 1145-1151.

doi:10.5455/njppp.2019.9.0931023092019001

Chicago Style

Chika, Aminu, Amina Yahaya, Abubakar Amali Muhammad, and Muhammad Bashiru Abdulrahman. "Influence of coadministration of metformin and methanolic stem extract of Anisopus mannii N.E.Br. (Apocynaceae) on glucose homeostasis and lipid profile in streptozotocin/nicotinamide-induced diabetic rats." National Journal of Physiology, Pharmacy and Pharmacology 9 (2019), 1145-1151.

doi:10.5455/njppp.2019.9.0931023092019001

MLA (The Modern Language Association) Style

doi:10.5455/njppp.2019.9.0931023092019001

APA (American Psychological Association) Style

doi:10.5455/njppp.2019.9.0931023092019001

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