E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research

Online Publishing Date:
06 / 07 / 2022

 


Cost-minimization analysis of drugs used for empirical treatment of urinary tract infection in a tertiary care hospital

Mangala Bhaskar Murthy, Dipti Ghumre, Pankaj Joshi, Bhaskar Murthy, Shraddha Pore, Shreyas Burute.


Abstract
Background: Urinary tract infections (UTIs) are one of the commonly encountered infections and a large number of drugs are indicated in UTI ranging from oral conventional drugs to most advanced injectable drugs. Cost-minimization analysis (CMA) is employed to project the least costly drug when two treatments are shown to be therapeutic equivalents.

Aims and Objectives: This study aims to perform a CMA at a tertiary care center to determine the least expensive drug for UTI and to project a cheapest alternative from available options based on the results of CMA.

Materials and Methods: This was a cross-sectional study conducted over duration of 3 months in the clinical departments on patients diagnosed to have UTI and prescribed empirical antimicrobial treatment. The approval of Institutional Ethics Committee was sought before beginning the study. Pattern of drug prescription and average cost incurred in the treatment of patients with empirical antimicrobial therapy was calculated. CMA included the projection of the least expensive drug based on average cost incurred per patient in outpatients and inpatients respectively.

Results: A total of 59 patients of UTI given empirical treatment were included in the study. Fluoroquinolones and cephalosporins were commonly used drugs for empirical treatment of UTI. Nitrofurantoin (average cost of 11–14 Rs. per patient) can be projected as the cheapest drug for empirical treatment of UTI on outpatient basis as well as a drug to supplement injectables in indoor patients. Injectable ciprofloxacin can be projected as the most inexpensive alternative for empirical treatment of UTI in patients of the inpatient department.

Conclusion: Nitrofurantoin for oral treatment and ciprofloxacin in injectable form are cheapest among available alternatives for empirical treatment of UTI. To prevent treatment failures and increase in cost of treatment, correlation of results of CMA with local antimicrobial sensitivity pattern is important.

Key words: Cost-Minimization Analysis; Rational Drug Use; Urinary Tract Infection; Empirical Treatment


 
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How to Cite this Article
Pubmed Style

Murthy MB, Ghumre D, Joshi P, Murthy B, Pore S, Burute S. Cost-minimization analysis of drugs used for empirical treatment of urinary tract infection in a tertiary care hospital. Natl J Physiol Pharm Pharmacol. 2023; 13(2): 295-300. doi:10.5455/njppp.2023.13.06304202224062022


Web Style

Murthy MB, Ghumre D, Joshi P, Murthy B, Pore S, Burute S. Cost-minimization analysis of drugs used for empirical treatment of urinary tract infection in a tertiary care hospital. https://www.njppp.com/?mno=66059 [Access: March 15, 2024]. doi:10.5455/njppp.2023.13.06304202224062022


AMA (American Medical Association) Style

Murthy MB, Ghumre D, Joshi P, Murthy B, Pore S, Burute S. Cost-minimization analysis of drugs used for empirical treatment of urinary tract infection in a tertiary care hospital. Natl J Physiol Pharm Pharmacol. 2023; 13(2): 295-300. doi:10.5455/njppp.2023.13.06304202224062022



Vancouver/ICMJE Style

Murthy MB, Ghumre D, Joshi P, Murthy B, Pore S, Burute S. Cost-minimization analysis of drugs used for empirical treatment of urinary tract infection in a tertiary care hospital. Natl J Physiol Pharm Pharmacol. (2023), [cited March 15, 2024]; 13(2): 295-300. doi:10.5455/njppp.2023.13.06304202224062022



Harvard Style

Murthy, M. B., Ghumre, . D., Joshi, . P., Murthy, . B., Pore, . S. & Burute, . S. (2023) Cost-minimization analysis of drugs used for empirical treatment of urinary tract infection in a tertiary care hospital. Natl J Physiol Pharm Pharmacol, 13 (2), 295-300. doi:10.5455/njppp.2023.13.06304202224062022



Turabian Style

Murthy, Mangala Bhaskar, Dipti Ghumre, Pankaj Joshi, Bhaskar Murthy, Shraddha Pore, and Shreyas Burute. 2023. Cost-minimization analysis of drugs used for empirical treatment of urinary tract infection in a tertiary care hospital. National Journal of Physiology, Pharmacy and Pharmacology, 13 (2), 295-300. doi:10.5455/njppp.2023.13.06304202224062022



Chicago Style

Murthy, Mangala Bhaskar, Dipti Ghumre, Pankaj Joshi, Bhaskar Murthy, Shraddha Pore, and Shreyas Burute. "Cost-minimization analysis of drugs used for empirical treatment of urinary tract infection in a tertiary care hospital." National Journal of Physiology, Pharmacy and Pharmacology 13 (2023), 295-300. doi:10.5455/njppp.2023.13.06304202224062022



MLA (The Modern Language Association) Style

Murthy, Mangala Bhaskar, Dipti Ghumre, Pankaj Joshi, Bhaskar Murthy, Shraddha Pore, and Shreyas Burute. "Cost-minimization analysis of drugs used for empirical treatment of urinary tract infection in a tertiary care hospital." National Journal of Physiology, Pharmacy and Pharmacology 13.2 (2023), 295-300. Print. doi:10.5455/njppp.2023.13.06304202224062022



APA (American Psychological Association) Style

Murthy, M. B., Ghumre, . D., Joshi, . P., Murthy, . B., Pore, . S. & Burute, . S. (2023) Cost-minimization analysis of drugs used for empirical treatment of urinary tract infection in a tertiary care hospital. National Journal of Physiology, Pharmacy and Pharmacology, 13 (2), 295-300. doi:10.5455/njppp.2023.13.06304202224062022