E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research 


Biochemical evaluation of DPP4 inhibitors on lipid profile in type 2 diabetes mellitus patients: A hospital-based prospective study

Bhuvaneswari S, Suresh Bhalaji S, Mohamed Sajeed, Hussain A.

Abstract
Background: Lipid lowering action of oral hypoglycemic drugs is still unclear. Hence, this study was conducted to address the same using monotherapy and with combination of oral hypoglycemic in patients suffering with type 2 diabetes.

Aims and Objectives: The main aim and objective of the study was to evaluate the DPP4 inhibitors inducted changes in low-density lipoprotein (LDL), VLSL, high-density lipoprotein (HDL), and total cholesterol (TC) in patients suffering with type 2 diabetes.

Materials and Methods: This randomized control study was done in the Department of General Medicine, Chennai Medical College Hospital and Research Center, Irungalur, Tiruchirappalli, between June 2014 and July 2015. Cases with type 2 diabetes mellitus (T2DM) aged 30–70 years who had been on glibenclamide or metformin for the past 3 months and had uncontrolled blood glucose levels were selected for the study. Total 180 patients are fulfilling the inclusion and exclusion criteria were divided into six groups (Each with 30 patients.) At the 0th and 12th weeks, fasting lipid profile was assessed. The data were expressed in number, percentage, mean, and standard deviation.

Results: Oral hypoglycemic drug either as monotherapy or in combination has significant effect on lipid profile among the cases with T2DM. Furthermore, the significant decrease in TC and maximum improvement in HDL was noted with the use of glibenclamide in combination with Sitagliptin and maximum reduction in triglycerides and LDL was noted with the use of Metformin in combination with Sitagliptin.

Conclusion: Oral hypoglycemic agents have an additional favorable effect on lipid profile among the cases with T2DM.

Key words: Oral Hypoglycemic Agents; Fasting Lipid Profile; Diabetes Mellitus


 
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How to Cite this Article
Pubmed Style

S B, S SB, Sajeed M, A H. Biochemical evaluation of DPP4 inhibitors on lipid profile in type 2 diabetes mellitus patients: A hospital-based prospective study. Natl J Physiol Pharm Pharmacol. 2022; 12(12): 2159-2162. doi:10.5455/njppp.2022.12.094742022003112022


Web Style

S B, S SB, Sajeed M, A H. Biochemical evaluation of DPP4 inhibitors on lipid profile in type 2 diabetes mellitus patients: A hospital-based prospective study. https://www.njppp.com/?mno=118290 [Access: February 02, 2023]. doi:10.5455/njppp.2022.12.094742022003112022


AMA (American Medical Association) Style

S B, S SB, Sajeed M, A H. Biochemical evaluation of DPP4 inhibitors on lipid profile in type 2 diabetes mellitus patients: A hospital-based prospective study. Natl J Physiol Pharm Pharmacol. 2022; 12(12): 2159-2162. doi:10.5455/njppp.2022.12.094742022003112022



Vancouver/ICMJE Style

S B, S SB, Sajeed M, A H. Biochemical evaluation of DPP4 inhibitors on lipid profile in type 2 diabetes mellitus patients: A hospital-based prospective study. Natl J Physiol Pharm Pharmacol. (2022), [cited February 02, 2023]; 12(12): 2159-2162. doi:10.5455/njppp.2022.12.094742022003112022



Harvard Style

S, B., S, . S. B., Sajeed, . M. & A, . H. (2022) Biochemical evaluation of DPP4 inhibitors on lipid profile in type 2 diabetes mellitus patients: A hospital-based prospective study. Natl J Physiol Pharm Pharmacol, 12 (12), 2159-2162. doi:10.5455/njppp.2022.12.094742022003112022



Turabian Style

S, Bhuvaneswari, Suresh Bhalaji S, Mohamed Sajeed, and Hussain A. 2022. Biochemical evaluation of DPP4 inhibitors on lipid profile in type 2 diabetes mellitus patients: A hospital-based prospective study. National Journal of Physiology, Pharmacy and Pharmacology, 12 (12), 2159-2162. doi:10.5455/njppp.2022.12.094742022003112022



Chicago Style

S, Bhuvaneswari, Suresh Bhalaji S, Mohamed Sajeed, and Hussain A. "Biochemical evaluation of DPP4 inhibitors on lipid profile in type 2 diabetes mellitus patients: A hospital-based prospective study." National Journal of Physiology, Pharmacy and Pharmacology 12 (2022), 2159-2162. doi:10.5455/njppp.2022.12.094742022003112022



MLA (The Modern Language Association) Style

S, Bhuvaneswari, Suresh Bhalaji S, Mohamed Sajeed, and Hussain A. "Biochemical evaluation of DPP4 inhibitors on lipid profile in type 2 diabetes mellitus patients: A hospital-based prospective study." National Journal of Physiology, Pharmacy and Pharmacology 12.12 (2022), 2159-2162. Print. doi:10.5455/njppp.2022.12.094742022003112022



APA (American Psychological Association) Style

S, B., S, . S. B., Sajeed, . M. & A, . H. (2022) Biochemical evaluation of DPP4 inhibitors on lipid profile in type 2 diabetes mellitus patients: A hospital-based prospective study. National Journal of Physiology, Pharmacy and Pharmacology, 12 (12), 2159-2162. doi:10.5455/njppp.2022.12.094742022003112022