E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research 


Patterns, causality, severity, and preventability of adverse drug reactions: An observational study at a tertiary health-care center

Leena Anthony, Pundarikaksha H P.

Abstract
Background: Adverse drug reactions (ADRs) are among the top leading causes of death, adversely affect the quality of life by increasing hospital stay, treatment cost, and morbidity. Spontaneous reporting of ADRs by health-care professionals (HCP) helps in signal detection and enables regulatory agencies to formulate drug use guidelines, issue warnings, or even ban/withdraw the drug from the market. Dissemination of knowledge regarding the patterns of ADRs seen in adverse drug reaction monitoring centers (AMCs) among HCP will enable to promote awareness on ADRs, help in early detection, and encourage them to be more vigilant so as to prevent recurrence of ADRs.

Aims and Objectives: We conducted an observational study, with the following objectives. The aim of the study was to determine the pattern of ADRs reported to AMC at PESIMSR, causality assessment, severity score, and preventability.

Materials and Methods: We conducted an observational, retrospective, and questionnaire-based study in PESIMSR AMC, Department of Pharmacology. The study period was between January 2016 and December 2016. All ADRs reported to the AMC in the above period were collected by convenient sampling method. Data collected includes patient characteristics such as age, gender, details of the reaction, details regarding suspected drugs, treatment, and outcome of ADR details as outlined in the standard CDSCO ADR notification form. Data were entered in SPSS version 22. Descriptive statistics used and values are expressed in frequency and percentages.

Results: A total of 153 cases were taken for analysis. Among them, 52% were males and 48% were females. The incidence of ADRs was higher (26%) among third and fourth decade than other age groups. Most frequent classes of drugs causing ADRs are antibiotics (44%) followed by analgesics (10%) and oral hypoglycemics (6%). The most frequently reported ADRs were cutaneous reactions. According to the WHO scale for causality assessment, 59% were possible ADRs. According to modified Hartwig Seigel’s severity assessment scale, about 16% were assessed as severe reactions. About 39% were probably preventable ADRs as assessed by modified Schummock and Thornton scale.

Conclusion: Hospital-based ADR monitoring and reporting programs aim to identify and quantify the risks associated with the use of drugs. This study gives an insight to emphasize the awareness to the health-care providers on vigilant monitoring of ADRs and promptly reporting the same so as to prevent the occurrence of the reactions in vulnerable population.

Key words: Adverse Drug Reaction; Pharmacovigilance; Causality; Severity; Preventability; Schummock and Thornton Scale


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Leena Anthony
Articles by Pundarikaksha H P
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

Anthony L, P PH. Patterns, causality, severity, and preventability of adverse drug reactions: An observational study at a tertiary health-care center. Natl J Physiol Pharm Pharmacol. 2022; 12(12): 2155-2158. doi:10.5455/njppp.2022.12.104912022021102022


Web Style

Anthony L, P PH. Patterns, causality, severity, and preventability of adverse drug reactions: An observational study at a tertiary health-care center. https://www.njppp.com/?mno=120693 [Access: February 02, 2023]. doi:10.5455/njppp.2022.12.104912022021102022


AMA (American Medical Association) Style

Anthony L, P PH. Patterns, causality, severity, and preventability of adverse drug reactions: An observational study at a tertiary health-care center. Natl J Physiol Pharm Pharmacol. 2022; 12(12): 2155-2158. doi:10.5455/njppp.2022.12.104912022021102022



Vancouver/ICMJE Style

Anthony L, P PH. Patterns, causality, severity, and preventability of adverse drug reactions: An observational study at a tertiary health-care center. Natl J Physiol Pharm Pharmacol. (2022), [cited February 02, 2023]; 12(12): 2155-2158. doi:10.5455/njppp.2022.12.104912022021102022



Harvard Style

Anthony, L. & P, . P. H. (2022) Patterns, causality, severity, and preventability of adverse drug reactions: An observational study at a tertiary health-care center. Natl J Physiol Pharm Pharmacol, 12 (12), 2155-2158. doi:10.5455/njppp.2022.12.104912022021102022



Turabian Style

Anthony, Leena, and Pundarikaksha H P. 2022. Patterns, causality, severity, and preventability of adverse drug reactions: An observational study at a tertiary health-care center. National Journal of Physiology, Pharmacy and Pharmacology, 12 (12), 2155-2158. doi:10.5455/njppp.2022.12.104912022021102022



Chicago Style

Anthony, Leena, and Pundarikaksha H P. "Patterns, causality, severity, and preventability of adverse drug reactions: An observational study at a tertiary health-care center." National Journal of Physiology, Pharmacy and Pharmacology 12 (2022), 2155-2158. doi:10.5455/njppp.2022.12.104912022021102022



MLA (The Modern Language Association) Style

Anthony, Leena, and Pundarikaksha H P. "Patterns, causality, severity, and preventability of adverse drug reactions: An observational study at a tertiary health-care center." National Journal of Physiology, Pharmacy and Pharmacology 12.12 (2022), 2155-2158. Print. doi:10.5455/njppp.2022.12.104912022021102022



APA (American Psychological Association) Style

Anthony, L. & P, . P. H. (2022) Patterns, causality, severity, and preventability of adverse drug reactions: An observational study at a tertiary health-care center. National Journal of Physiology, Pharmacy and Pharmacology, 12 (12), 2155-2158. doi:10.5455/njppp.2022.12.104912022021102022