E-ISSN 2231-3206 | ISSN 2320-4672
 

Review Article 


Systemic therapy with bromelain-trypsin-rutoside combination in inflammation: A narrative review of the pharmacodynamics

Gautam Vinod Daftary, Anand Pravin Shah, Ganesh Harishchandra Divekar, James John, Nikita Nilesh Patil, Bhushan Mhala Khemnar.

Abstract
Inflammation and wound healing are attended by interactions of numerous cell types, mediators, cytokines, and the vascular system. Any imbalance in these interactions can set off a cascade of processes, often working in different directions, and which continue till homeostasis is restored. Systemic enzyme therapy with trypsin-bromelain-rutoside combination has long been used as dietary supplements or pharmaceuticals commercially to counter various inflammatory conditions. The clinical benefits are believed to be due to the multipronged action of the combination, which include anti-kinin, antioxidant, antiplatelet, anti-chemokine, pro-fibrinolytic, and pro-fibrotic activities; with more recent evidence indicating inhibition of pro-inflammatory signal transduction. The primary modes of action of the individual agents on different components and processes involved in inflammation have been evaluated and elucidated, using various in vitro, animal model, and clinical studies. A narrative review of the evidence collected over the years has been provided.

Key words: Inflammation; Enzymes; Trypsin; Bromelain; Rutin


 
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How to Cite this Article
Pubmed Style

Daftary GV, Shah AP, Divekar GH, John J, Patil NN, Khemnar BM. Systemic therapy with bromelain-trypsin-rutoside combination in inflammation: A narrative review of the pharmacodynamics. Natl J Physiol Pharm Pharmacol. 2022; 12(10): 1521-1528. doi:10.5455/njppp.2022.12.10374202125022022


Web Style

Daftary GV, Shah AP, Divekar GH, John J, Patil NN, Khemnar BM. Systemic therapy with bromelain-trypsin-rutoside combination in inflammation: A narrative review of the pharmacodynamics. https://www.njppp.com/?mno=130330 [Access: December 01, 2022]. doi:10.5455/njppp.2022.12.10374202125022022


AMA (American Medical Association) Style

Daftary GV, Shah AP, Divekar GH, John J, Patil NN, Khemnar BM. Systemic therapy with bromelain-trypsin-rutoside combination in inflammation: A narrative review of the pharmacodynamics. Natl J Physiol Pharm Pharmacol. 2022; 12(10): 1521-1528. doi:10.5455/njppp.2022.12.10374202125022022



Vancouver/ICMJE Style

Daftary GV, Shah AP, Divekar GH, John J, Patil NN, Khemnar BM. Systemic therapy with bromelain-trypsin-rutoside combination in inflammation: A narrative review of the pharmacodynamics. Natl J Physiol Pharm Pharmacol. (2022), [cited December 01, 2022]; 12(10): 1521-1528. doi:10.5455/njppp.2022.12.10374202125022022



Harvard Style

Daftary, G. V., Shah, . A. P., Divekar, . G. H., John, . J., Patil, . N. N. & Khemnar, . B. M. (2022) Systemic therapy with bromelain-trypsin-rutoside combination in inflammation: A narrative review of the pharmacodynamics. Natl J Physiol Pharm Pharmacol, 12 (10), 1521-1528. doi:10.5455/njppp.2022.12.10374202125022022



Turabian Style

Daftary, Gautam Vinod, Anand Pravin Shah, Ganesh Harishchandra Divekar, James John, Nikita Nilesh Patil, and Bhushan Mhala Khemnar. 2022. Systemic therapy with bromelain-trypsin-rutoside combination in inflammation: A narrative review of the pharmacodynamics. National Journal of Physiology, Pharmacy and Pharmacology, 12 (10), 1521-1528. doi:10.5455/njppp.2022.12.10374202125022022



Chicago Style

Daftary, Gautam Vinod, Anand Pravin Shah, Ganesh Harishchandra Divekar, James John, Nikita Nilesh Patil, and Bhushan Mhala Khemnar. "Systemic therapy with bromelain-trypsin-rutoside combination in inflammation: A narrative review of the pharmacodynamics." National Journal of Physiology, Pharmacy and Pharmacology 12 (2022), 1521-1528. doi:10.5455/njppp.2022.12.10374202125022022



MLA (The Modern Language Association) Style

Daftary, Gautam Vinod, Anand Pravin Shah, Ganesh Harishchandra Divekar, James John, Nikita Nilesh Patil, and Bhushan Mhala Khemnar. "Systemic therapy with bromelain-trypsin-rutoside combination in inflammation: A narrative review of the pharmacodynamics." National Journal of Physiology, Pharmacy and Pharmacology 12.10 (2022), 1521-1528. Print. doi:10.5455/njppp.2022.12.10374202125022022



APA (American Psychological Association) Style

Daftary, G. V., Shah, . A. P., Divekar, . G. H., John, . J., Patil, . N. N. & Khemnar, . B. M. (2022) Systemic therapy with bromelain-trypsin-rutoside combination in inflammation: A narrative review of the pharmacodynamics. National Journal of Physiology, Pharmacy and Pharmacology, 12 (10), 1521-1528. doi:10.5455/njppp.2022.12.10374202125022022