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Original Research

Online Publishing Date:
19 / 04 / 2023

 


Changes of biochemical profile of tribal pediatric patients with acute viral hepatitis A at the time of admission - a cross-sectional study

Suman Chatterjee, Bhaskar Chowdhury, Utsav Das.


Abstract
Background: Hepatitis A is a self-limited liver disease which can produce a significant cause of morbidity in parts of the world in pediatric population with low socioeconomic background. Hepatitis A can cause significant changes in liver functions changing its parameters.

Aims and Objectives: The aim and objective of the study are to determine the biochemical changes in viral hepatitis A in tribal pediatric patients at the time of admission.

Materials and Methods: This cross-sectional observational study was conducted in Deben Mahata Government Medical College and Hospital, Purulia, on confirmed newly diagnosed 100 hepatitis A tribal patients over a period of 12 months. Serum total and direct bilirubin, ALT, AST, alkaline phosphatase, total protein, and albumin were measured and data obtained were analyzed using appropriate statistical method.

Results: Data collected from total hepatitis A patients were analyzed. Overall, 53% were male. 71% patients out of 100 presented with serum direct bilirubin level between 0.5 and 2.0 mg/dL and only 4 had more than 4.0 mg/dL. More than 5-fold rise in ALT and AST were seen in 75% and 82% cases, respectively. More than 1000U/L of ALT and AST were seen in 3 cases (3%) and 2 cases (2%), respectively. Among study population, alkaline phosphatase was elevated in 24% cases and 14% cases had hypoproteinemia. Nine cases admitted with raised blood urea level and one case with raised creatinine level.

Conclusion: Hepatitis A produces alteration of the parameters of liver function.

Key words: Hepatitis A; Bilirubin; ALT; AST; Alkaline Phosphatase; Total Protein and Albumin


 
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How to Cite this Article
Pubmed Style

Chatterjee S, Chowdhury B, Das U. Changes of biochemical profile of tribal pediatric patients with acute viral hepatitis A at the time of admission - a cross-sectional study. Natl J Physiol Pharm Pharmacol. 2023; 13(10): 2168-2171. doi:10.5455/njppp.2023.13.04169202308042023

Web Style

Chatterjee S, Chowdhury B, Das U. Changes of biochemical profile of tribal pediatric patients with acute viral hepatitis A at the time of admission - a cross-sectional study. https://www.njppp.com/?mno=148283 [Access: March 14, 2024]. doi:10.5455/njppp.2023.13.04169202308042023

AMA (American Medical Association) Style

Chatterjee S, Chowdhury B, Das U. Changes of biochemical profile of tribal pediatric patients with acute viral hepatitis A at the time of admission - a cross-sectional study. Natl J Physiol Pharm Pharmacol. 2023; 13(10): 2168-2171. doi:10.5455/njppp.2023.13.04169202308042023


Vancouver/ICMJE Style

Chatterjee S, Chowdhury B, Das U. Changes of biochemical profile of tribal pediatric patients with acute viral hepatitis A at the time of admission - a cross-sectional study. Natl J Physiol Pharm Pharmacol. (2023), [cited March 14, 2024]; 13(10): 2168-2171. doi:10.5455/njppp.2023.13.04169202308042023


Harvard Style

Chatterjee, S., Chowdhury, . B. & Das, . U. (2023) Changes of biochemical profile of tribal pediatric patients with acute viral hepatitis A at the time of admission - a cross-sectional study. Natl J Physiol Pharm Pharmacol, 13 (10), 2168-2171. doi:10.5455/njppp.2023.13.04169202308042023


Turabian Style

Chatterjee, Suman, Bhaskar Chowdhury, and Utsav Das. 2023. Changes of biochemical profile of tribal pediatric patients with acute viral hepatitis A at the time of admission - a cross-sectional study. National Journal of Physiology, Pharmacy and Pharmacology, 13 (10), 2168-2171. doi:10.5455/njppp.2023.13.04169202308042023


Chicago Style

Chatterjee, Suman, Bhaskar Chowdhury, and Utsav Das. "Changes of biochemical profile of tribal pediatric patients with acute viral hepatitis A at the time of admission - a cross-sectional study." National Journal of Physiology, Pharmacy and Pharmacology 13 (2023), 2168-2171. doi:10.5455/njppp.2023.13.04169202308042023


MLA (The Modern Language Association) Style

Chatterjee, Suman, Bhaskar Chowdhury, and Utsav Das. "Changes of biochemical profile of tribal pediatric patients with acute viral hepatitis A at the time of admission - a cross-sectional study." National Journal of Physiology, Pharmacy and Pharmacology 13.10 (2023), 2168-2171. Print. doi:10.5455/njppp.2023.13.04169202308042023


APA (American Psychological Association) Style

Chatterjee, S., Chowdhury, . B. & Das, . U. (2023) Changes of biochemical profile of tribal pediatric patients with acute viral hepatitis A at the time of admission - a cross-sectional study. National Journal of Physiology, Pharmacy and Pharmacology, 13 (10), 2168-2171. doi:10.5455/njppp.2023.13.04169202308042023


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