Classical autonomic function tests in patients with type 2 diabetes mellitus and healthy volunteers: A comparative study

Mohan Jayabal; Dinesh Thangavel; Uma Maheswari Thiyagarajan; Nagashree Ramasamy; Venkatesan Rangan; Venkidusamy Subramaniyam

doi:10.5455/njppp.2015.5.160820141

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Original Research
Online Published: 18 Jan 2015

Natl J Physiol Pharm Pharmacol. 2015; 5(1): 68-71

doi: 10.5455/njppp.2015.5.160820141

Classical autonomic function tests in patients with type 2 diabetes mellitus and healthy volunteers: A comparative study

Mohan Jayabal, Dinesh Thangavel, Uma Maheswari Thiyagarajan, Nagashree Ramasamy, Venkatesan Rangan, Venkidusamy Subramaniyam.

Cited By:3

Abstract
Background: The incidence of autonomic dysfunction has increased in the setting of type 2 diabetes mellitus and various tools have been developed for assessing it. Classical autonomic function tests are one among them.

Objective: To compare the classical autonomic function tests in type 2 diabetes mellitus patients and healthy volunteers

Materials and methods: The present study was conducted at PSG Institute of Medical Sciences and Research, Coimbatore, Tamilnadu on 30 type 2 diabetic patients (cases) and 30 healthy volunteers (controls). Average age of the diabetic patients was 48.53 ± 5.12 (Mean ± SD) and that of volunteers was 47.10 ±3.59 (Mean ± SD). After obtaining informed, written consent Cardio-respiratory parameters such as resting heart rate (HR), systolic blood pressure (SBP) and diastolic blood pressure (DBP) were measured after 10 minutes of supine rest and autonomic function parameters (AFT) such as heart rate and blood pressure response to handgrip, deep breathing difference test and Valsalvo ratio were recorded in them.

Results: Statistical analysis done by using independent Students 't test, showed a statistically significant impairment in heart rate response to handgrip (P<0.001), blood pressure response to handgrip (P<0.001), deep breathing test (P<0.001) and Valsalvo ratio (P<0.001).

Conclusion: Results of the present study showed that compared to healthy volunteers significant impairment was present in type 2 diabetes mellitus patients and it was more pronounced for parasympathetic system than sympathetic system.

Key words: Classical autonomic function tests, type 2 diabetes mellitus, healthy volunteers

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Pubmed Style

Jayabal M, Thangavel D, Thiyagarajan UM, Ramasamy N, Rangan V, Subramaniyam V. Classical autonomic function tests in patients with type 2 diabetes mellitus and healthy volunteers: A comparative study. Natl J Physiol Pharm Pharmacol. 2015; 5(1): 68-71. doi:10.5455/njppp.2015.5.160820141

Web Style

Jayabal M, Thangavel D, Thiyagarajan UM, Ramasamy N, Rangan V, Subramaniyam V. Classical autonomic function tests in patients with type 2 diabetes mellitus and healthy volunteers: A comparative study. https://www.njppp.com/?mno=165670 [Access: November 02, 2025]. doi:10.5455/njppp.2015.5.160820141

AMA (American Medical Association) Style

Jayabal M, Thangavel D, Thiyagarajan UM, Ramasamy N, Rangan V, Subramaniyam V. Classical autonomic function tests in patients with type 2 diabetes mellitus and healthy volunteers: A comparative study. Natl J Physiol Pharm Pharmacol. 2015; 5(1): 68-71. doi:10.5455/njppp.2015.5.160820141

Vancouver/ICMJE Style

Jayabal M, Thangavel D, Thiyagarajan UM, Ramasamy N, Rangan V, Subramaniyam V. Classical autonomic function tests in patients with type 2 diabetes mellitus and healthy volunteers: A comparative study. Natl J Physiol Pharm Pharmacol. (2015), [cited November 02, 2025]; 5(1): 68-71. doi:10.5455/njppp.2015.5.160820141

Harvard Style

Jayabal, M., Thangavel, . D., Thiyagarajan, . U. M., Ramasamy, . N., Rangan, . V. & Subramaniyam, . V. (2015) Classical autonomic function tests in patients with type 2 diabetes mellitus and healthy volunteers: A comparative study. Natl J Physiol Pharm Pharmacol, 5 (1), 68-71. doi:10.5455/njppp.2015.5.160820141

Turabian Style

Jayabal, Mohan, Dinesh Thangavel, Uma Maheswari Thiyagarajan, Nagashree Ramasamy, Venkatesan Rangan, and Venkidusamy Subramaniyam. 2015. Classical autonomic function tests in patients with type 2 diabetes mellitus and healthy volunteers: A comparative study. National Journal of Physiology, Pharmacy and Pharmacology, 5 (1), 68-71. doi:10.5455/njppp.2015.5.160820141

Chicago Style

Jayabal, Mohan, Dinesh Thangavel, Uma Maheswari Thiyagarajan, Nagashree Ramasamy, Venkatesan Rangan, and Venkidusamy Subramaniyam. "Classical autonomic function tests in patients with type 2 diabetes mellitus and healthy volunteers: A comparative study." National Journal of Physiology, Pharmacy and Pharmacology 5 (2015), 68-71. doi:10.5455/njppp.2015.5.160820141

MLA (The Modern Language Association) Style

APA (American Psychological Association) Style

Jayabal, M., Thangavel, . D., Thiyagarajan, . U. M., Ramasamy, . N., Rangan, . V. & Subramaniyam, . V. (2015) Classical autonomic function tests in patients with type 2 diabetes mellitus and healthy volunteers: A comparative study. National Journal of Physiology, Pharmacy and Pharmacology, 5 (1), 68-71. doi:10.5455/njppp.2015.5.160820141

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