Effects of subchronic exposure of PSP Ganoderma lucidum on renal function and histopathology feature in Rattus novergicus Wistar strain

Titin Andri Wihastuti; Djanggan Sargowo; Mohammad Aris Widodo; Teuku Heriansyah; Setyowati Soeharto; Kenti Wantri Anita; Novita Qurrota Aini

doi:10.5455/njppp.2015.5.0603201539

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Online Published: 16 Sep 2015

Natl J Physiol Pharm Pharmacol. 2015; 5(4): 296-302

doi: 10.5455/njppp.2015.5.0603201539

Effects of subchronic exposure of PSP Ganoderma lucidum on renal function and histopathology feature in Rattus novergicus Wistar strain

Titin Andri Wihastuti, Djanggan Sargowo, Mohammad Aris Widodo, Teuku Heriansyah, Setyowati Soeharto, Kenti Wantri Anita, Novita Qurrota Aini.

Cited By:9

Abstract
Background: Ganoderma lucidum, commonly referred to as Lingzhi in China, is a fungus that has been widely used through the centuries for the general promotion of health and longevity in Asian countries.

Aims and Objective: To determine the effects of subchronic exposure of PSP G. lucidum on renal function and renal histopathology feature in Rattus novergicus Wistar strain.

Materials and Methods: A total of 80 male and female Wistar rats, aged 23 months with a body weight of 200300 g, were divided into four treatment groups: dose group 0 (control group), group PSP G. lucidum dose of 300, 600, and 1200 mg/kg for 90 days. Parameters measured were urea and creatinine levels and renal histopathology feature.

Result: From the research, the highest urea levels were found in the group in which female Wistar rats were treated with PSP dose of 300 mg/kg/day with an average concentration of urea of 33.2 mg/dL, whereas creatinine levels were found to be equally high on treatment with PSP dose of 1200, 600, and 300 mg/kg/day with an average concentration of urea of 0.3 mg/dL. On histopathological examination, no morphological abnormalities were found. The results of one-way analysis of variance test showed no significant difference at all PSP G. lucidum doses.

Conclusion: It is concluded that giving PSP G. lucidum in three variant doses does not cause dysfunction and histological damage to the renal function.

Key words: PSP Ganoderma lucidum; Subchronic Exposure; Urea; Creatinine; Renal Organ Histopathology

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Pubmed Style

Wihastuti TA, Sargowo D, Widodo MA, Heriansyah T, Soeharto S, Anita KW, Aini NQ. Effects of subchronic exposure of PSP Ganoderma lucidum on renal function and histopathology feature in Rattus novergicus Wistar strain. Natl J Physiol Pharm Pharmacol. 2015; 5(4): 296-302. doi:10.5455/njppp.2015.5.0603201539

Web Style

Wihastuti TA, Sargowo D, Widodo MA, Heriansyah T, Soeharto S, Anita KW, Aini NQ. Effects of subchronic exposure of PSP Ganoderma lucidum on renal function and histopathology feature in Rattus novergicus Wistar strain. https://www.njppp.com/?mno=181788 [Access: June 27, 2026]. doi:10.5455/njppp.2015.5.0603201539

AMA (American Medical Association) Style

Wihastuti TA, Sargowo D, Widodo MA, Heriansyah T, Soeharto S, Anita KW, Aini NQ. Effects of subchronic exposure of PSP Ganoderma lucidum on renal function and histopathology feature in Rattus novergicus Wistar strain. Natl J Physiol Pharm Pharmacol. 2015; 5(4): 296-302. doi:10.5455/njppp.2015.5.0603201539

Vancouver/ICMJE Style

Wihastuti TA, Sargowo D, Widodo MA, Heriansyah T, Soeharto S, Anita KW, Aini NQ. Effects of subchronic exposure of PSP Ganoderma lucidum on renal function and histopathology feature in Rattus novergicus Wistar strain. Natl J Physiol Pharm Pharmacol. (2015), [cited June 27, 2026]; 5(4): 296-302. doi:10.5455/njppp.2015.5.0603201539

Harvard Style

Wihastuti, T. A., Sargowo, . D., Widodo, . M. A., Heriansyah, . T., Soeharto, . S., Anita, . K. W. & Aini, . N. Q. (2015) Effects of subchronic exposure of PSP Ganoderma lucidum on renal function and histopathology feature in Rattus novergicus Wistar strain. Natl J Physiol Pharm Pharmacol, 5 (4), 296-302. doi:10.5455/njppp.2015.5.0603201539

Turabian Style

Wihastuti, Titin Andri, Djanggan Sargowo, Mohammad Aris Widodo, Teuku Heriansyah, Setyowati Soeharto, Kenti Wantri Anita, and Novita Qurrota Aini. 2015. Effects of subchronic exposure of PSP Ganoderma lucidum on renal function and histopathology feature in Rattus novergicus Wistar strain. National Journal of Physiology, Pharmacy and Pharmacology, 5 (4), 296-302. doi:10.5455/njppp.2015.5.0603201539

Chicago Style

Wihastuti, Titin Andri, Djanggan Sargowo, Mohammad Aris Widodo, Teuku Heriansyah, Setyowati Soeharto, Kenti Wantri Anita, and Novita Qurrota Aini. "Effects of subchronic exposure of PSP Ganoderma lucidum on renal function and histopathology feature in Rattus novergicus Wistar strain." National Journal of Physiology, Pharmacy and Pharmacology 5 (2015), 296-302. doi:10.5455/njppp.2015.5.0603201539

MLA (The Modern Language Association) Style

Wihastuti, Titin Andri, Djanggan Sargowo, Mohammad Aris Widodo, Teuku Heriansyah, Setyowati Soeharto, Kenti Wantri Anita, and Novita Qurrota Aini. "Effects of subchronic exposure of PSP Ganoderma lucidum on renal function and histopathology feature in Rattus novergicus Wistar strain." National Journal of Physiology, Pharmacy and Pharmacology 5.4 (2015), 296-302. Print. doi:10.5455/njppp.2015.5.0603201539

APA (American Psychological Association) Style

Wihastuti, T. A., Sargowo, . D., Widodo, . M. A., Heriansyah, . T., Soeharto, . S., Anita, . K. W. & Aini, . N. Q. (2015) Effects of subchronic exposure of PSP Ganoderma lucidum on renal function and histopathology feature in Rattus novergicus Wistar strain. National Journal of Physiology, Pharmacy and Pharmacology, 5 (4), 296-302. doi:10.5455/njppp.2015.5.0603201539

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