Assessment of memory and cognitive functions in controlled and uncontrolled Type 2 diabetes mellitus patients

Shanthi Muthiah; Rekha Kanagamuthu; Saravanan Mohanraj; Shree Lakshmi K N

doi:10.5455/njppp.2019.9.1135508122018

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Original Research
Online Published: 25 Dec 2018

Natl J Physiol Pharm Pharmacol. 2019; 9(2): 140-144

doi: 10.5455/njppp.2019.9.1135508122018

Assessment of memory and cognitive functions in controlled and uncontrolled Type 2 diabetes mellitus patients

Shanthi Muthiah, Rekha Kanagamuthu, Saravanan Mohanraj, Shree Lakshmi K N.

Cited By:3

Abstract
Background: In Type 2 diabetes (T2D) mellitus, chronic hyperglycemia and hyperinsulinemia with resultant increased advanced glycosylated end products cause the acceleration of the brain aging in its structure and functions. This complication increases the risk of memory and cognitive dysfunctions.

Aims and Objectives: This study was aimed to compare the memory and cognitive functions between controlled and uncontrolled T2D mellitus patients.

Materials and Methods: The study is undertaken in the Department of Physiology, Velammal Medical College Hospital, Madurai. 100 known T2D mellitus patients aged between 30 and 50 years of both sexes are included after obtaining informed written consent. Patients with conditions and factors affecting memory and patients with defective hearing and speech are excluded from the study. Recent hemoglobin A1c (HbA1c), fasting blood sugar (FBS), and postprandial blood sugar (PPBS) values are collected from their hospital records. Cognition and memory assessment is done using Mini-Mental State Examination (MMSE) by 30-point questionnaire.

Results: The average MMSE score of uncontrolled diabetes mellitus is less than the average MMSE score of controlled diabetes mellitus patients (HbA1c<7). Students unpaired t-test among these two groups for MMSE was statistically significant (P = 0.02). The duration of diabetes mellitus, FBS, PPBS, and HbA1c showed negative correlation with MMSE score.

Conclusion: The above result shows that there is more impairment in memory and cognitive functions in the uncontrolled than the controlled diabetes mellitus patients.

Key words: Type 2 diabetes mellitus; Memory and Cognition; Mini-Mental State Examination, Hemoglobin A1c

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Pubmed Style

Muthiah S, Kanagamuthu R, Mohanraj S, N SLK. Assessment of memory and cognitive functions in controlled and uncontrolled Type 2 diabetes mellitus patients. Natl J Physiol Pharm Pharmacol. 2019; 9(2): 140-144. doi:10.5455/njppp.2019.9.1135508122018

Web Style

Muthiah S, Kanagamuthu R, Mohanraj S, N SLK. Assessment of memory and cognitive functions in controlled and uncontrolled Type 2 diabetes mellitus patients. https://www.njppp.com/?mno=19238 [Access: March 08, 2025]. doi:10.5455/njppp.2019.9.1135508122018

AMA (American Medical Association) Style

Muthiah S, Kanagamuthu R, Mohanraj S, N SLK. Assessment of memory and cognitive functions in controlled and uncontrolled Type 2 diabetes mellitus patients. Natl J Physiol Pharm Pharmacol. 2019; 9(2): 140-144. doi:10.5455/njppp.2019.9.1135508122018

Vancouver/ICMJE Style

Muthiah S, Kanagamuthu R, Mohanraj S, N SLK. Assessment of memory and cognitive functions in controlled and uncontrolled Type 2 diabetes mellitus patients. Natl J Physiol Pharm Pharmacol. (2019), [cited March 08, 2025]; 9(2): 140-144. doi:10.5455/njppp.2019.9.1135508122018

Harvard Style

Muthiah, S., Kanagamuthu, . R., Mohanraj, . S. & N, . S. L. K. (2019) Assessment of memory and cognitive functions in controlled and uncontrolled Type 2 diabetes mellitus patients. Natl J Physiol Pharm Pharmacol, 9 (2), 140-144. doi:10.5455/njppp.2019.9.1135508122018

Turabian Style

Muthiah, Shanthi, Rekha Kanagamuthu, Saravanan Mohanraj, and Shree Lakshmi K N. 2019. Assessment of memory and cognitive functions in controlled and uncontrolled Type 2 diabetes mellitus patients. National Journal of Physiology, Pharmacy and Pharmacology, 9 (2), 140-144. doi:10.5455/njppp.2019.9.1135508122018

Chicago Style

Muthiah, Shanthi, Rekha Kanagamuthu, Saravanan Mohanraj, and Shree Lakshmi K N. "Assessment of memory and cognitive functions in controlled and uncontrolled Type 2 diabetes mellitus patients." National Journal of Physiology, Pharmacy and Pharmacology 9 (2019), 140-144. doi:10.5455/njppp.2019.9.1135508122018

MLA (The Modern Language Association) Style

Muthiah, Shanthi, Rekha Kanagamuthu, Saravanan Mohanraj, and Shree Lakshmi K N. "Assessment of memory and cognitive functions in controlled and uncontrolled Type 2 diabetes mellitus patients." National Journal of Physiology, Pharmacy and Pharmacology 9.2 (2019), 140-144. Print. doi:10.5455/njppp.2019.9.1135508122018

APA (American Psychological Association) Style

Muthiah, S., Kanagamuthu, . R., Mohanraj, . S. & N, . S. L. K. (2019) Assessment of memory and cognitive functions in controlled and uncontrolled Type 2 diabetes mellitus patients. National Journal of Physiology, Pharmacy and Pharmacology, 9 (2), 140-144. doi:10.5455/njppp.2019.9.1135508122018

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