E-ISSN 2231-3206 | ISSN 2320-4672
 
2024, Vol: 14, Issue: 10
14 / 10Current Issue Online First Archive Aims and Scope Abstracting & Indexing Most Accessed Articles Most Downloaded Articles Most Cited Articles
Required files to be uploaded

Authorship Declaration

Original Research
Online Published: 16 Apr 2024
 


A comparative study on safety and efficacy of tablet thiocolchicoside 4 mg + aceclofenac 100 mg versus tablet paracetamol 500 mg + aceclofenac 100 mg in treatment of patients with acute lower back pain: A randomized double-blind study

Naga Nandini Bokka, Surendra Kumar Gondi, Deepthi Rani Bodda, Siva Prasad K V.


Abstract
Background: Lower backache is a highly prevalent condition among middle-aged individuals and is often caused by muscle spasms. It is one of the most common reasons why people seek medical assistance from a primary care physician.

Aims and Objectives: The aims and objectives of the study are to evaluate the safety and efficacy of the drug combinations thiocolchicoside 4 mg and aceclofenac 100 mg versus aceclofenac 100 mg and paracetamol 500 mg.

Materials and Methods: The study was conducted using a prospective, randomized, double-blind, comparative, and parallel group design. A total of 80 patients who met the specified criteria were selected to participate in the trial over a period of 3 months. A total of 30 cases were selected for each group, with consideration given to excluding outliers. The patients were allocated randomly into two groups: Group A, consisting of 30 individuals, and Group B, consisting of 30 individuals. The primary efficacy assessments include the visual analog scale, muscle spasm assessment by finger-to-floor distance, and Lasegue’s maneuver. The secondary efficacy measures were assessed using a 4-point scale global assessment, which included ratings of excellent, good, average, and poor.

Results: The majority of study participants were in the age group 39–48 years and above 48 years consisting of 25 patients and 33, respectively. Males constituted 51.6% and females were 48.3%. On day 28, results were calculated on 26 patients in Group A and 24 patients in Group B as 10 patients discontinued the treatment after 3rd week.

Conclusions: It is concluded that the best possible medical intervention to treat acute low back pain is to use drug combinations of analgesics and skeletal muscle relaxants. The combination of tablet thiocolchicoside and aceclofenac proved to be more efficacious and safer when compared to the combination of tablet aceclofenac and paracetamol.

Key words: Low Backache; Muscle Relaxants; Fixed-dose Combinations; Non-steroidal Anti-inflammatory Drugs; Visual Analog Scale; Comparative; Efficacy; Aceclofenac; Thiocolchicoside


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Naga Nandini Bokka
Articles by Surendra Kumar Gondi
Articles by Deepthi Rani Bodda
Articles by Siva Prasad K V
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

Bokka NN, Gondi SK, Bodda DR, V SPK. A comparative study on safety and efficacy of tablet thiocolchicoside 4 mg + aceclofenac 100 mg versus tablet paracetamol 500 mg + aceclofenac 100 mg in treatment of patients with acute lower back pain: A randomized double-blind study. Natl J Physiol Pharm Pharmacol. 2024; 14(9): 1858-1864. doi:10.5455/njppp.2024.14.04146202404042024

Web Style

Bokka NN, Gondi SK, Bodda DR, V SPK. A comparative study on safety and efficacy of tablet thiocolchicoside 4 mg + aceclofenac 100 mg versus tablet paracetamol 500 mg + aceclofenac 100 mg in treatment of patients with acute lower back pain: A randomized double-blind study. https://www.njppp.com/?mno=196099 [Access: October 03, 2024]. doi:10.5455/njppp.2024.14.04146202404042024

AMA (American Medical Association) Style

Bokka NN, Gondi SK, Bodda DR, V SPK. A comparative study on safety and efficacy of tablet thiocolchicoside 4 mg + aceclofenac 100 mg versus tablet paracetamol 500 mg + aceclofenac 100 mg in treatment of patients with acute lower back pain: A randomized double-blind study. Natl J Physiol Pharm Pharmacol. 2024; 14(9): 1858-1864. doi:10.5455/njppp.2024.14.04146202404042024


Vancouver/ICMJE Style

Bokka NN, Gondi SK, Bodda DR, V SPK. A comparative study on safety and efficacy of tablet thiocolchicoside 4 mg + aceclofenac 100 mg versus tablet paracetamol 500 mg + aceclofenac 100 mg in treatment of patients with acute lower back pain: A randomized double-blind study. Natl J Physiol Pharm Pharmacol. (2024), [cited October 03, 2024]; 14(9): 1858-1864. doi:10.5455/njppp.2024.14.04146202404042024


Harvard Style

Bokka, N. N., Gondi, . S. K., Bodda, . D. R. & V, . S. P. K. (2024) A comparative study on safety and efficacy of tablet thiocolchicoside 4 mg + aceclofenac 100 mg versus tablet paracetamol 500 mg + aceclofenac 100 mg in treatment of patients with acute lower back pain: A randomized double-blind study. Natl J Physiol Pharm Pharmacol, 14 (9), 1858-1864. doi:10.5455/njppp.2024.14.04146202404042024


Turabian Style

Bokka, Naga Nandini, Surendra Kumar Gondi, Deepthi Rani Bodda, and Siva Prasad K V. 2024. A comparative study on safety and efficacy of tablet thiocolchicoside 4 mg + aceclofenac 100 mg versus tablet paracetamol 500 mg + aceclofenac 100 mg in treatment of patients with acute lower back pain: A randomized double-blind study. National Journal of Physiology, Pharmacy and Pharmacology, 14 (9), 1858-1864. doi:10.5455/njppp.2024.14.04146202404042024


Chicago Style

Bokka, Naga Nandini, Surendra Kumar Gondi, Deepthi Rani Bodda, and Siva Prasad K V. "A comparative study on safety and efficacy of tablet thiocolchicoside 4 mg + aceclofenac 100 mg versus tablet paracetamol 500 mg + aceclofenac 100 mg in treatment of patients with acute lower back pain: A randomized double-blind study." National Journal of Physiology, Pharmacy and Pharmacology 14 (2024), 1858-1864. doi:10.5455/njppp.2024.14.04146202404042024


MLA (The Modern Language Association) Style

Bokka, Naga Nandini, Surendra Kumar Gondi, Deepthi Rani Bodda, and Siva Prasad K V. "A comparative study on safety and efficacy of tablet thiocolchicoside 4 mg + aceclofenac 100 mg versus tablet paracetamol 500 mg + aceclofenac 100 mg in treatment of patients with acute lower back pain: A randomized double-blind study." National Journal of Physiology, Pharmacy and Pharmacology 14.9 (2024), 1858-1864. Print. doi:10.5455/njppp.2024.14.04146202404042024


APA (American Psychological Association) Style

Bokka, N. N., Gondi, . S. K., Bodda, . D. R. & V, . S. P. K. (2024) A comparative study on safety and efficacy of tablet thiocolchicoside 4 mg + aceclofenac 100 mg versus tablet paracetamol 500 mg + aceclofenac 100 mg in treatment of patients with acute lower back pain: A randomized double-blind study. National Journal of Physiology, Pharmacy and Pharmacology, 14 (9), 1858-1864. doi:10.5455/njppp.2024.14.04146202404042024




Most Viewed Articles
Most Accessed Articles

  • Applications of computer science in Pharmacy: An overview
    Shivraj Popat Jadhav, Komal Nikam, Anand Gandhi, Kishor Salunkhe, Narendra Shinde.
    Natl J Physiol Pharm Pharmacol. 2012; 2(1): 1-9
    » Abstract

  • How to calculate sample size in animal studies?
    Hitesh Shah
    Natl J Physiol Pharm Pharmacol. 2011; 1(1): 35-39
    » Abstract

  • Chlorhexidine:The gold standard in chemical plaque control [English]
    Setu mathur, Tanu mathur,Rahul shrivastava, Rohit khatri
    Natl J Physiol Pharm Pharmacol. 2011; 1(2): 45-50
    » Abstract

  • Assessment of Nutritional Status of Pregnant Women Attending the City Tebessa PMI (Algeria) [English]
    Taleb Salima, Kaibi Mounira, Deghboudj Nadjia
    Natl J Physiol Pharm Pharmacol. 2011; 1(2): 97-105
    » Abstract

  • Difference in pulmonary function test among the athletic and sedentary population
    ShobhaRani Vedala, Niranjan Paul, Abhay B Mane
    Natl J Physiol Pharm Pharmacol. 2013; 3(2): 118-123
    » Abstract » doi: 10.5455/njppp.2013.3.109-114

    •
    Most Downloaded
    Top Downloaded Articles

  • How to calculate sample size in animal studies?
    Hitesh Shah
    Natl J Physiol Pharm Pharmacol. 2011; 1(1): 35-39
    » Abstract

  • Applications of computer science in Pharmacy: An overview
    Shivraj Popat Jadhav, Komal Nikam, Anand Gandhi, Kishor Salunkhe, Narendra Shinde.
    Natl J Physiol Pharm Pharmacol. 2012; 2(1): 1-9
    » Abstract

  • Evaluation of potential drug-drug interaction in indoor patients of pediatric department of tertiary care hospital
    Simran Patel, Mayur Chaudhari, Nrupal Patel
    Natl J Physiol Pharm Pharmacol. 2019; 9(10): 1012-1016
    » Abstract » doi: 10.5455/njppp.2019.9.0725209072019

  • Chlorhexidine:The gold standard in chemical plaque control [English]
    Setu mathur, Tanu mathur,Rahul shrivastava, Rohit khatri
    Natl J Physiol Pharm Pharmacol. 2011; 1(2): 45-50
    » Abstract

  • Analyzing Pharmaceutical Industry [English]
    Veselin Tima Dickov, Dragan Mitrovic, Boris Milan Kuzman
    Natl J Physiol Pharm Pharmacol. 2011; 1(1): 1-8
    » Abstract » doi: 10.5455/njppp.2011.1.1-8

    •
    Most Cited Articles
    Most Cited Articles

    About National Journal of Physiology, Pharmacy and Pharmacology

      National Journal of Physiology, Pharmacy and Pharmacology is a monthly peer reviewed journal.  The journal is having open access polic ... Read more.



    For best results, please use Internet Explorer or Google Chrome.

    Contact Information

    Eldaghayes Publisher

    www.eldagpublisher.com 

     
    All correspondence should be addressed to:
    Prof. Ibrahim Eldaghayes
    Editor-in-Chief
    National Journal of Physiology, Pharmacy and Pharmacology
    Email: ibrahim.eldaghayes@vetmed.edu.ly
    POLICIES & JOURNAL LINKS
    Author Login
    Reviewer Login
    About Publisher
    Advertising Policy
    Author's Rights and Obligations
    Conflict of Interest Policy
    Copyright Information
    Digital Archiving & Preservation Policies
    Editorial Policies
    Peer Review Policy
    Editorial & Peer Review Process
    License Information
    Open Access Policy
    Plagiarism Policy
    Privacy Policy
    Protection of Research Participants (Statement On Human And Animal Rights)
    Publication Ethics and Publication Malpractice Statement
    Corrections, Retractions & Expressions of Concern
    Self-Archiving Policies
    Statement of Informed Consent
    Terms of Use