E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research 


Anti-inflammatory and analgesic activity of aqueous extracts of dried leaves of Murraya koenigii Linn.

Ateendra Singh, Anamika Singh, Omi Chouhan, Gyan Prakash Tandi, Mitali Dua, Anusuya Gehlot.

Cited by (4)

Abstract
Background: Murraya koenigii, commonly known as karipatta or curry leaf, is analgesic and can be used effectively against inflammation and itching. The various pharmacological activities such as vasodilation, antimicrobial, antidiabetic, antiulcer, analgesic, phagocytic, and antioxidant activities of this plant have also been reported.

Aims and Objectives: To evaluate the anti-inflammatory and analgesic activity of aqueous extract of dried leaves of M. koenigii Linn. in male Wistar rats.

Materials and Methods: Adult male Wistar rats (100–150 g body weight) were used in this study. Aqueous extract of M. koenigii Linn. was used to evaluate acute anti-inflammatory and analgesic activity by plethysmometer and hot plate method by oral administration at doses of 100, 300, and 500 mg/kg body weight in healthy albino rats.

Result: In acute studies, the aqueous extract showed anti-inflammatory activity by significant reduction in the paw edema volume, in a dose-dependent manner when compared with the control and standard drug. Aqueous extract of M. koenigii Linn. significantly and dose-dependently reduced the number of acetic acid-induced writhing and significantly increased the latency of paw licking in hot plate method. Statistical analysis was carried out by one-way ANOVA, followed by Turkey's test.

Conclusion: Aqueous extract of M. koenigii Linn. possesses both anti-inflammatory and analgesic activity in a dose-dependent manner.

Key words: Murraya koenigii; Anti-inflammatory; Analgesic; Carrageenan; Paw Edema


 
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REFERENCES
1. Kirtikar KR, Basu BD. Indian Medicinal Plants Vol. VI1975.
2. Rastogi P, Malhotra BN. Indian Medicinal Plants Vol. IVLucknow/New Delhi: Central Drug Research Institute/Council for Scientific and Industrial Research, 2011.
3. Shukla A. Medicinal plants for treatment of diabetes mellitus. Indian J Clin Biochem. 2000;15(Suppl.):169-77. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
4. Satyavati GV, Raina MK, Sharma M. Indian Medicinal Plants of India Vol. INew Delhi: Indian Council of Medical Research, 1976.
5. Kumari K, Mathew BC, Augusti KT. Antidiabetic and hypolipidemic effect of S-methyl cysteine sulfoxide isolated from Allium cepa Linn. Indian J Biochem Biophys. 1995;32(2):49-54. [Pubmed]   
6. American Diabetes A s s o c i a t i o n. Diagnosis and classification of diabetes mellitus. Diabetic Care. 2007;1(30):42-6.
7. Satyavati GV, Gupta AK, Tendon N. Medicinal Plants of India. New Delhi: Indian Council of Medical Research, 1987. pp. 289-99.
8. Harish K, Anup P, Shruthi SD. A review on Murraya koenigii: multipotential medicinal plant. Asian J Pharm Clin Res. 2012; 5(4):5-14.
9. Gupta P, Nahata A, Dixit V. An update on Murraya koenigii spreng: a multifunctional Ayurvedic herb. Zhong Xi Yi Jie He Xue Bao. 2011; 9(8):824-33. [DOI via Crossref]    [Pubmed]   
10. Christina L, Albert S. Iron-complexes extracted from curry leaves and their use 2009. EP20090011884.
11. Ganga RG, Rama RG, Trimurtulu G. New synergistic phytochemical composition for the treatment of obesity 2009. WO2009066303.
12. Rao LJM, Ramalakshmia K, Borsea BB, Raghavana B. Antioxidant and radical-scavenging carbazole alkaloids from the oleoresin of curry leaf (Murraya koenigii spreng). Food Chem. 2007;100(2):742-7. [DOI via Crossref]   
13. Yankuzo H, Ahmed QU, Santosa RI, Akter SF, Talib NA. Beneficial effect of the leaves of Murraya koenigii (Linn.) spreng (Rutaceae) on diabetes-induced renal damage in vivo. J Ethnopharmacol. 2011;135(1):88-94. [DOI via Crossref]    [Pubmed]   
14. Mukhopadhyay S, Chakraborty M, Mukherjee T, Bandyopadhyay A, Kar D, Banerjee T, et al. Method for treatment of bronchial asthma 2012. US20120202868/2013, US8519154.
15. Banerjee S, Sur TP, Mandal S, Das PC, Sikdar S. Assessment of the antiinflammatory effects of Swertia chirata in acute and chronic experimental models in male albino rats. Indian J Pharmacol. 2000;32:21-4.
16. Kale M, Misar AV, Dave V, Joshi M, Mujumdar AM. Anti-inflammatory activity of Dalbergia lanceolaria barks ethanol extract in mice and rats. J Ethnopharmacol. 2007;112:300-4. [DOI via Crossref]    [Pubmed]   
17. Vinegar R, Schreiber W, Hugo R. Biphasic development of carrageenin edema in rats. J Pharmacol Exp Ther. 1969;166: 96-103. [Pubmed]   
18. Marchioro M, Blank Mde F, Mourao RH, Antoniolli AR. Antinociceptive activity of aqueous extract of Erythrina velutina leaves. Fitoterapia. 2005;76:637-42. [DOI via Crossref]    [Pubmed]   
19. Richardson JD, Aanonsen L, Hargreaves KM. Antihyperalgesic effects of spinal cannabinoids. Eur J Pharmacol. 1998;345: 145-53. [DOI via Crossref]   
20. Chapman CR, Casey KL, Dubner R, Foley KM, Gracely RH, Reading AE. Pain measurement: an overview. Pain. 1985;22: 1-31. [DOI via Crossref]   
21. Dhawan BN, Cesselin F, Raghubir R, Reisine T, Bradley PB, Protoghese PS, et al. Classification of opioid receptors. Pharmacol Rev. 1996;48:567-92. [Pubmed]   
22. Lipman AG, Jackson RC. Principles and Practice of Pain Medicine, 2nd edn., New York: McGraw-Hill, 2004. pp. 585-8.
23. Deraedt R, Jougney S, Delevalcee F, Falhout M. Release of prostaglandin E and F in an algogenic reaction and its inhibition. Eur J Pharmacol. 1980;51:17-24. [DOI via Crossref]   
24. Amico-Roxas M, Caruso A, Trombadore S, Scifo R, Scapagnini U. Gangliosides antinociceptive effects in rodents. Arch Int Pharmacodyn Ther. 1984;272:103-17. [Pubmed]   
25. Fernanda LB, Victor AK, Amelia TH. Analgesic property of umbelletin from Psychotria umbellate. Pharm Biol. 2004;44:56.
26. Onasanwo SA, Elegbe RA. Antinociceptive and anti-inflammatory effect of the leaf extracts of Hedranthera barteri in rats and mice. African J Biomed Res. 2000;14:418.

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How to Cite this Article
Pubmed Style

Ateendra Singh, Anamika Singh, Omi Chouhan, Gyan Prakash Tandi, Mitali Dua, Anusuya Gehlot. Anti-inflammatory and analgesic activity of aqueous extracts of dried leaves of Murraya koenigii Linn.. Natl J Physiol Pharm Pharmacol. 2016; 6(4): 286-290. doi:10.5455/njppp.2016.6.09122015123


Web Style

Ateendra Singh, Anamika Singh, Omi Chouhan, Gyan Prakash Tandi, Mitali Dua, Anusuya Gehlot. Anti-inflammatory and analgesic activity of aqueous extracts of dried leaves of Murraya koenigii Linn.. https://www.njppp.com/?mno=210380 [Access: January 03, 2023]. doi:10.5455/njppp.2016.6.09122015123


AMA (American Medical Association) Style

Ateendra Singh, Anamika Singh, Omi Chouhan, Gyan Prakash Tandi, Mitali Dua, Anusuya Gehlot. Anti-inflammatory and analgesic activity of aqueous extracts of dried leaves of Murraya koenigii Linn.. Natl J Physiol Pharm Pharmacol. 2016; 6(4): 286-290. doi:10.5455/njppp.2016.6.09122015123



Vancouver/ICMJE Style

Ateendra Singh, Anamika Singh, Omi Chouhan, Gyan Prakash Tandi, Mitali Dua, Anusuya Gehlot. Anti-inflammatory and analgesic activity of aqueous extracts of dried leaves of Murraya koenigii Linn.. Natl J Physiol Pharm Pharmacol. (2016), [cited January 03, 2023]; 6(4): 286-290. doi:10.5455/njppp.2016.6.09122015123



Harvard Style

Ateendra Singh, Anamika Singh, Omi Chouhan, Gyan Prakash Tandi, Mitali Dua, Anusuya Gehlot (2016) Anti-inflammatory and analgesic activity of aqueous extracts of dried leaves of Murraya koenigii Linn.. Natl J Physiol Pharm Pharmacol, 6 (4), 286-290. doi:10.5455/njppp.2016.6.09122015123



Turabian Style

Ateendra Singh, Anamika Singh, Omi Chouhan, Gyan Prakash Tandi, Mitali Dua, Anusuya Gehlot. 2016. Anti-inflammatory and analgesic activity of aqueous extracts of dried leaves of Murraya koenigii Linn.. National Journal of Physiology, Pharmacy and Pharmacology, 6 (4), 286-290. doi:10.5455/njppp.2016.6.09122015123



Chicago Style

Ateendra Singh, Anamika Singh, Omi Chouhan, Gyan Prakash Tandi, Mitali Dua, Anusuya Gehlot. "Anti-inflammatory and analgesic activity of aqueous extracts of dried leaves of Murraya koenigii Linn.." National Journal of Physiology, Pharmacy and Pharmacology 6 (2016), 286-290. doi:10.5455/njppp.2016.6.09122015123



MLA (The Modern Language Association) Style

Ateendra Singh, Anamika Singh, Omi Chouhan, Gyan Prakash Tandi, Mitali Dua, Anusuya Gehlot. "Anti-inflammatory and analgesic activity of aqueous extracts of dried leaves of Murraya koenigii Linn.." National Journal of Physiology, Pharmacy and Pharmacology 6.4 (2016), 286-290. Print. doi:10.5455/njppp.2016.6.09122015123



APA (American Psychological Association) Style

Ateendra Singh, Anamika Singh, Omi Chouhan, Gyan Prakash Tandi, Mitali Dua, Anusuya Gehlot (2016) Anti-inflammatory and analgesic activity of aqueous extracts of dried leaves of Murraya koenigii Linn.. National Journal of Physiology, Pharmacy and Pharmacology, 6 (4), 286-290. doi:10.5455/njppp.2016.6.09122015123