E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research
Online Published: 27 Dec 2024


Thyroid hormone levels in gestational diabetes mellitus – A cross-sectional study

Renu Meena Mathialagan, Deepalakshmi K.


Abstract
Background:
Gestational Diabetes Mellitus (GDM) is a most common complication occurs during pregnancy. Thyroid hormones are the critical regulators of body metabolism, influencing both maternal and fetal outcomes during pregnancy. The pregnant women with hypothyroidism are more prone to develop increased insulin resistance which potentially contributes to the development of GDM.

Objective:
To find out the association of thyroid hormone levels with blood sugar levels in GDM women

Methods:
This cross-sectional study was conducted among 60 pregnant women having Gestational Diabetes Mellitus in the second and trimester of pregnancy Based on Thyroid Stimulating Hormone values, they were divided into two groups (A & B).Fasting Blood Sugar (FBS) and the Post Prandial Blood Sugar (PPBS) were noted for both the groups. Association of thyroid profile with their blood glucose levels was performed using Pearson’s correlation. Students paired ‘t’ test was employed to analyse parametric data.

Results:
The fasting blood sugar levels were found to be increased (115.448 ± 32.361) in comparison to patients of normal TSH values with p value 0.0032. The post prandial blood sugar levels (184.379± 53.751) were also found to be increased (p -0.0084). On correlation with FBS, TSH values showed no statistical significance in both groups. The post prandial blood sugar levels showed statistically significant correlation with higher TSH value (p value 0.000273) when compared to people with normal TSH values.

Conclusion:
In our present study, we observed the significant increase in the blood glucose levels in GDM women with high TSH values.Thus early screening of GDM women for thyroid function reduce the thyroid dysfunction in fetus

Key words: Gestational Diabetes Mellitus (GDM), Thyroid Stimulating Hormone (TSH), Fasting Blood Sugar (FBS), Post Prandial Blood Sugar (PPBS)


 
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How to Cite this Article
Pubmed Style

Mathialagan RM, K D. Thyroid hormone levels in gestational diabetes mellitus – A cross-sectional study. Natl J Physiol Pharm Pharmacol. 2024; 14(12): 2521-2524. doi:10.5455/NJPPP.2024.v14.i12.4


Web Style

Mathialagan RM, K D. Thyroid hormone levels in gestational diabetes mellitus – A cross-sectional study. https://www.njppp.com/?mno=213848 [Access: February 06, 2025]. doi:10.5455/NJPPP.2024.v14.i12.4


AMA (American Medical Association) Style

Mathialagan RM, K D. Thyroid hormone levels in gestational diabetes mellitus – A cross-sectional study. Natl J Physiol Pharm Pharmacol. 2024; 14(12): 2521-2524. doi:10.5455/NJPPP.2024.v14.i12.4



Vancouver/ICMJE Style

Mathialagan RM, K D. Thyroid hormone levels in gestational diabetes mellitus – A cross-sectional study. Natl J Physiol Pharm Pharmacol. (2024), [cited February 06, 2025]; 14(12): 2521-2524. doi:10.5455/NJPPP.2024.v14.i12.4



Harvard Style

Mathialagan, R. M. & K, . D. (2024) Thyroid hormone levels in gestational diabetes mellitus – A cross-sectional study. Natl J Physiol Pharm Pharmacol, 14 (12), 2521-2524. doi:10.5455/NJPPP.2024.v14.i12.4



Turabian Style

Mathialagan, Renu Meena, and Deepalakshmi K. 2024. Thyroid hormone levels in gestational diabetes mellitus – A cross-sectional study. National Journal of Physiology, Pharmacy and Pharmacology, 14 (12), 2521-2524. doi:10.5455/NJPPP.2024.v14.i12.4



Chicago Style

Mathialagan, Renu Meena, and Deepalakshmi K. "Thyroid hormone levels in gestational diabetes mellitus – A cross-sectional study." National Journal of Physiology, Pharmacy and Pharmacology 14 (2024), 2521-2524. doi:10.5455/NJPPP.2024.v14.i12.4



MLA (The Modern Language Association) Style

Mathialagan, Renu Meena, and Deepalakshmi K. "Thyroid hormone levels in gestational diabetes mellitus – A cross-sectional study." National Journal of Physiology, Pharmacy and Pharmacology 14.12 (2024), 2521-2524. Print. doi:10.5455/NJPPP.2024.v14.i12.4



APA (American Psychological Association) Style

Mathialagan, R. M. & K, . D. (2024) Thyroid hormone levels in gestational diabetes mellitus – A cross-sectional study. National Journal of Physiology, Pharmacy and Pharmacology, 14 (12), 2521-2524. doi:10.5455/NJPPP.2024.v14.i12.4