E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research
Online Published: 27 Dec 2024


Assessment of etiology and pharmacotherapy of patients with anemia in chronic myeloid leukemia: Challenges and opportunities in a tertiary care government hospital

Ritadeepa Jana, Shuvra Neel Baul, Sandeep Saha, Suman Chattopadhyay, Ananya Mandal, Arijit Ghosh.


Abstract
Background:
Chronic Myeloid Leukaemia (CML) is the most prevalent blood malignancy in India. Anemia, splenomegaly, weight loss, fatigue are the most common symptoms and Imatinib, a first generation Tyrosine kinase inhibitor (TKI) is the choice of treatment.

Aim:
The objective of the study was to assess the etiology of anemia in CML and the pattern of pharmacotherapy, medication adherence and adverse drug reaction (ADR) in these patients in a tertiary care government hospital.

Methods:
This cross sectional observational study was conducted between January 2023 and May 2024 on 40 patients of all age groups and of both sexes, presented with CML and anemia to outpatient department of hematology. General, hematological and cytogenetic investigations were done to assess the outcome of treatment. Drug adherence and ADRs were also assessed.

Results:
Of the participants 25% were male and Imatinib mesylate, was the mainstay of treatment (92%) which is supplied free of cost. High rate of medication adherence was noted (85%). A total of 70 ADRs were noted among the patients participating in the study commonest being anemia (55%).

Conclusion:
Anemia remains a major problem in management of CML patients and need continuous assessment and management.

Key words: Chronic myeloid leukemia, Imatinib mesylate, Adverse drug reaction


 
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How to Cite this Article
Pubmed Style

Jana R, Baul SN, Saha S, Chattopadhyay S, Mandal A, Ghosh A. Assessment of etiology and pharmacotherapy of patients with anemia in chronic myeloid leukemia: Challenges and opportunities in a tertiary care government hospital. Natl J Physiol Pharm Pharmacol. 2024; 14(12): 2525-2529. doi:10.5455/NJPPP.2024.v14.i12.5


Web Style

Jana R, Baul SN, Saha S, Chattopadhyay S, Mandal A, Ghosh A. Assessment of etiology and pharmacotherapy of patients with anemia in chronic myeloid leukemia: Challenges and opportunities in a tertiary care government hospital. https://www.njppp.com/?mno=227780 [Access: February 07, 2025]. doi:10.5455/NJPPP.2024.v14.i12.5


AMA (American Medical Association) Style

Jana R, Baul SN, Saha S, Chattopadhyay S, Mandal A, Ghosh A. Assessment of etiology and pharmacotherapy of patients with anemia in chronic myeloid leukemia: Challenges and opportunities in a tertiary care government hospital. Natl J Physiol Pharm Pharmacol. 2024; 14(12): 2525-2529. doi:10.5455/NJPPP.2024.v14.i12.5



Vancouver/ICMJE Style

Jana R, Baul SN, Saha S, Chattopadhyay S, Mandal A, Ghosh A. Assessment of etiology and pharmacotherapy of patients with anemia in chronic myeloid leukemia: Challenges and opportunities in a tertiary care government hospital. Natl J Physiol Pharm Pharmacol. (2024), [cited February 07, 2025]; 14(12): 2525-2529. doi:10.5455/NJPPP.2024.v14.i12.5



Harvard Style

Jana, R., Baul, . S. N., Saha, . S., Chattopadhyay, . S., Mandal, . A. & Ghosh, . A. (2024) Assessment of etiology and pharmacotherapy of patients with anemia in chronic myeloid leukemia: Challenges and opportunities in a tertiary care government hospital. Natl J Physiol Pharm Pharmacol, 14 (12), 2525-2529. doi:10.5455/NJPPP.2024.v14.i12.5



Turabian Style

Jana, Ritadeepa, Shuvra Neel Baul, Sandeep Saha, Suman Chattopadhyay, Ananya Mandal, and Arijit Ghosh. 2024. Assessment of etiology and pharmacotherapy of patients with anemia in chronic myeloid leukemia: Challenges and opportunities in a tertiary care government hospital. National Journal of Physiology, Pharmacy and Pharmacology, 14 (12), 2525-2529. doi:10.5455/NJPPP.2024.v14.i12.5



Chicago Style

Jana, Ritadeepa, Shuvra Neel Baul, Sandeep Saha, Suman Chattopadhyay, Ananya Mandal, and Arijit Ghosh. "Assessment of etiology and pharmacotherapy of patients with anemia in chronic myeloid leukemia: Challenges and opportunities in a tertiary care government hospital." National Journal of Physiology, Pharmacy and Pharmacology 14 (2024), 2525-2529. doi:10.5455/NJPPP.2024.v14.i12.5



MLA (The Modern Language Association) Style

Jana, Ritadeepa, Shuvra Neel Baul, Sandeep Saha, Suman Chattopadhyay, Ananya Mandal, and Arijit Ghosh. "Assessment of etiology and pharmacotherapy of patients with anemia in chronic myeloid leukemia: Challenges and opportunities in a tertiary care government hospital." National Journal of Physiology, Pharmacy and Pharmacology 14.12 (2024), 2525-2529. Print. doi:10.5455/NJPPP.2024.v14.i12.5



APA (American Psychological Association) Style

Jana, R., Baul, . S. N., Saha, . S., Chattopadhyay, . S., Mandal, . A. & Ghosh, . A. (2024) Assessment of etiology and pharmacotherapy of patients with anemia in chronic myeloid leukemia: Challenges and opportunities in a tertiary care government hospital. National Journal of Physiology, Pharmacy and Pharmacology, 14 (12), 2525-2529. doi:10.5455/NJPPP.2024.v14.i12.5