To compare the efficacy of trimetazidine and diltiazem in chronic stable angina

Sharanjit Kaur; Sami Manzoor; Banta Singh; Harinder Jot Singh; Seema Rai; Diksha Kumari

doi:10.5455/njppp.2016.6.0101913062016

2026, Vol: 16, Issue: 1

16 / 1Current Issue Online First Archive Aims and Scope Abstracting & Indexing Most Accessed Articles Most Downloaded Articles Most Cited Articles

Required files to be uploaded

NJPPP Manuscript Submission Form
Title Page

« Previous Article

Original Research
Online Published: 23 Jun 2016

Natl J Physiol Pharm Pharmacol. 2016; 6(6): 526-530

doi: 10.5455/njppp.2016.6.0101913062016

To compare the efficacy of trimetazidine and diltiazem in chronic stable angina

Sharanjit Kaur, Sami Manzoor, Banta Singh, Harinder Jot Singh, Seema Rai, Diksha Kumari.

Cited By:1

Abstract
Background: Trimetazidine, a cytoprotective agent, is better anti-ischemic drug than conventional agents without causing any change in heart rate and blood pressure.

Aims and Objectives: To compare the efficacy of trimetazidine with diltiazem in chronic stable angina.

Materials and Methods: Thirty diagnosed cases of chronic stable angina were subjected to TMT I with total effort duration and time to precipitate angina being the end point. Patients were given 60 mg of trimetazidine for 8 weeks, in addition to their conventional treatment and subjected to another TMT II with the same end points. After a washout period of 2 weeks, the same patients were put on diltiazem 60 mg TDS for 8 weeks again with another third TMT III to evaluate the results.

Results: The mean age of all patients was 57.70 ± 8.44. The mean increase in effort duration between TMT II (7.50 ± 1.52) and I (6.21 ± 1.65 min) was 1.29 min which was statistically significant (P < 0.001) while difference between TMT III (7.21 ± 1.56) and I (6.21 ± 1.65 min) was 1.0 min (P < 0.05 s). The difference observed between TMT III and II was 0.29 (P > 0.05 not significant). The increase in time to ST-segment depression between TMT I and II was 1.35 min. (P < 0.001), whereas the difference between TMT I and III was 1.01 min (P < 0.05 significant). Anginal attacks per week with diltiazem were 1.81 ± 0.59 and 1.67 ± 0.52 with trimetazidine (P > 0.005).

Conclusions: The patients with stable angina had a better clinical improvement after treatment with trimetazidine, without any adverse effects.

Key words: Stable Angina; Diltiazem; Trimetazidine; Metabolic Modulators; Cytoprotection

	ARTICLE TOOLS
	Abstract
	PDF Fulltext
	How to cite this article
	Citation Tools
	Related Records
	Articles by Sharanjit Kaur Articles by Sami Manzoor Articles by Banta Singh Articles by Harinder Jot Singh Articles by Seema Rai Articles by Diksha Kumari
	on Google
	on Google Scholar

How to Cite this Article

Pubmed Style

Kaur S, Manzoor S, Singh B, Singh HJ, Rai S, Kumari D. To compare the efficacy of trimetazidine and diltiazem in chronic stable angina. Natl J Physiol Pharm Pharmacol. 2016; 6(6): 526-530. doi:10.5455/njppp.2016.6.0101913062016

Web Style

Kaur S, Manzoor S, Singh B, Singh HJ, Rai S, Kumari D. To compare the efficacy of trimetazidine and diltiazem in chronic stable angina. https://www.njppp.com/?mno=216236 [Access: June 26, 2026]. doi:10.5455/njppp.2016.6.0101913062016

AMA (American Medical Association) Style

Kaur S, Manzoor S, Singh B, Singh HJ, Rai S, Kumari D. To compare the efficacy of trimetazidine and diltiazem in chronic stable angina. Natl J Physiol Pharm Pharmacol. 2016; 6(6): 526-530. doi:10.5455/njppp.2016.6.0101913062016

Vancouver/ICMJE Style

Kaur S, Manzoor S, Singh B, Singh HJ, Rai S, Kumari D. To compare the efficacy of trimetazidine and diltiazem in chronic stable angina. Natl J Physiol Pharm Pharmacol. (2016), [cited June 26, 2026]; 6(6): 526-530. doi:10.5455/njppp.2016.6.0101913062016

Harvard Style

Kaur, S., Manzoor, . S., Singh, . B., Singh, . H. J., Rai, . S. & Kumari, . D. (2016) To compare the efficacy of trimetazidine and diltiazem in chronic stable angina. Natl J Physiol Pharm Pharmacol, 6 (6), 526-530. doi:10.5455/njppp.2016.6.0101913062016

Turabian Style

Kaur, Sharanjit, Sami Manzoor, Banta Singh, Harinder Jot Singh, Seema Rai, and Diksha Kumari. 2016. To compare the efficacy of trimetazidine and diltiazem in chronic stable angina. National Journal of Physiology, Pharmacy and Pharmacology, 6 (6), 526-530. doi:10.5455/njppp.2016.6.0101913062016

Chicago Style

Kaur, Sharanjit, Sami Manzoor, Banta Singh, Harinder Jot Singh, Seema Rai, and Diksha Kumari. "To compare the efficacy of trimetazidine and diltiazem in chronic stable angina." National Journal of Physiology, Pharmacy and Pharmacology 6 (2016), 526-530. doi:10.5455/njppp.2016.6.0101913062016

MLA (The Modern Language Association) Style

Kaur, Sharanjit, Sami Manzoor, Banta Singh, Harinder Jot Singh, Seema Rai, and Diksha Kumari. "To compare the efficacy of trimetazidine and diltiazem in chronic stable angina." National Journal of Physiology, Pharmacy and Pharmacology 6.6 (2016), 526-530. Print. doi:10.5455/njppp.2016.6.0101913062016

APA (American Psychological Association) Style

Kaur, S., Manzoor, . S., Singh, . B., Singh, . H. J., Rai, . S. & Kumari, . D. (2016) To compare the efficacy of trimetazidine and diltiazem in chronic stable angina. National Journal of Physiology, Pharmacy and Pharmacology, 6 (6), 526-530. doi:10.5455/njppp.2016.6.0101913062016

About National Journal of Physiology, Pharmacy and Pharmacology

Contact Information

How to cite this article