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Original Research

Online Publishing Date:
23 / 06 / 2016

 


To compare the efficacy of trimetazidine and diltiazem in chronic stable angina

Sharanjit Kaur, Sami Manzoor, Banta Singh, Harinder Jot Singh, Seema Rai, Diksha Kumari.


Abstract
Background: Trimetazidine, a cytoprotective agent, is better anti-ischemic drug than conventional agents without causing any change in heart rate and blood pressure.

Aims and Objectives: To compare the efficacy of trimetazidine with diltiazem in chronic stable angina.

Materials and Methods: Thirty diagnosed cases of chronic stable angina were subjected to TMT I with total effort duration and time to precipitate angina being the end point. Patients were given 60 mg of trimetazidine for 8 weeks, in addition to their conventional treatment and subjected to another TMT II with the same end points. After a washout period of 2 weeks, the same patients were put on diltiazem 60 mg TDS for 8 weeks again with another third TMT III to evaluate the results.

Results: The mean age of all patients was 57.70 ± 8.44. The mean increase in effort duration between TMT II (7.50 ± 1.52) and I (6.21 ± 1.65 min) was 1.29 min which was statistically significant (P < 0.001) while difference between TMT III (7.21 ± 1.56) and I (6.21 ± 1.65 min) was 1.0 min (P < 0.05 s). The difference observed between TMT III and II was 0.29 (P > 0.05 not significant). The increase in time to ST-segment depression between TMT I and II was 1.35 min. (P < 0.001), whereas the difference between TMT I and III was 1.01 min (P < 0.05 significant). Anginal attacks per week with diltiazem were 1.81 ± 0.59 and 1.67 ± 0.52 with trimetazidine (P > 0.005).

Conclusions: The patients with stable angina had a better clinical improvement after treatment with trimetazidine, without any adverse effects.

Key words: Stable Angina; Diltiazem; Trimetazidine; Metabolic Modulators; Cytoprotection


 
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How to Cite this Article
Pubmed Style

Sharanjit Kaur, Sami Manzoor, Banta Singh, Harinder Jot Singh, Seema Rai, Diksha Kumari. To compare the efficacy of trimetazidine and diltiazem in chronic stable angina. Natl J Physiol Pharm Pharmacol. 2016; 6(6): 526-530. doi:10.5455/njppp.2016.6.0101913062016

Web Style

Sharanjit Kaur, Sami Manzoor, Banta Singh, Harinder Jot Singh, Seema Rai, Diksha Kumari. To compare the efficacy of trimetazidine and diltiazem in chronic stable angina. https://www.njppp.com/?mno=216236 [Access: March 14, 2024]. doi:10.5455/njppp.2016.6.0101913062016

AMA (American Medical Association) Style

Sharanjit Kaur, Sami Manzoor, Banta Singh, Harinder Jot Singh, Seema Rai, Diksha Kumari. To compare the efficacy of trimetazidine and diltiazem in chronic stable angina. Natl J Physiol Pharm Pharmacol. 2016; 6(6): 526-530. doi:10.5455/njppp.2016.6.0101913062016


Vancouver/ICMJE Style

Sharanjit Kaur, Sami Manzoor, Banta Singh, Harinder Jot Singh, Seema Rai, Diksha Kumari. To compare the efficacy of trimetazidine and diltiazem in chronic stable angina. Natl J Physiol Pharm Pharmacol. (2016), [cited March 14, 2024]; 6(6): 526-530. doi:10.5455/njppp.2016.6.0101913062016


Harvard Style

Sharanjit Kaur, Sami Manzoor, Banta Singh, Harinder Jot Singh, Seema Rai, Diksha Kumari (2016) To compare the efficacy of trimetazidine and diltiazem in chronic stable angina. Natl J Physiol Pharm Pharmacol, 6 (6), 526-530. doi:10.5455/njppp.2016.6.0101913062016


Turabian Style

Sharanjit Kaur, Sami Manzoor, Banta Singh, Harinder Jot Singh, Seema Rai, Diksha Kumari. 2016. To compare the efficacy of trimetazidine and diltiazem in chronic stable angina. National Journal of Physiology, Pharmacy and Pharmacology, 6 (6), 526-530. doi:10.5455/njppp.2016.6.0101913062016


Chicago Style

Sharanjit Kaur, Sami Manzoor, Banta Singh, Harinder Jot Singh, Seema Rai, Diksha Kumari. "To compare the efficacy of trimetazidine and diltiazem in chronic stable angina." National Journal of Physiology, Pharmacy and Pharmacology 6 (2016), 526-530. doi:10.5455/njppp.2016.6.0101913062016


MLA (The Modern Language Association) Style

Sharanjit Kaur, Sami Manzoor, Banta Singh, Harinder Jot Singh, Seema Rai, Diksha Kumari. "To compare the efficacy of trimetazidine and diltiazem in chronic stable angina." National Journal of Physiology, Pharmacy and Pharmacology 6.6 (2016), 526-530. Print. doi:10.5455/njppp.2016.6.0101913062016


APA (American Psychological Association) Style

Sharanjit Kaur, Sami Manzoor, Banta Singh, Harinder Jot Singh, Seema Rai, Diksha Kumari (2016) To compare the efficacy of trimetazidine and diltiazem in chronic stable angina. National Journal of Physiology, Pharmacy and Pharmacology, 6 (6), 526-530. doi:10.5455/njppp.2016.6.0101913062016


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