E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research 


Vitamin E improves quality of life in patients with alcoholic liver disease

Bhanu Prakash Kolasani, Prasanand Sasidharan, Divyashanthi C M, Adithiya Kumar.

Cited by (1)

Abstract
Background: Alcoholic Liver Disease (ALD) is a major cause of morbidity and mortality not only in India but also worldwide. The evidence that oxidative stress is involved in the pathogenesis of ALD and Vitamin E deficiency being well documented in patients of ALD, an antioxidant like Vitamin E could likely be beneficial in patients with ALD.

Aims and Objectives: To study the effect of Vitamin E supplementation over a period of 12 weeks on Quality of life of patients with ALD.

Materials and Methods: This is a prospective, open labeled, randomized study involving a total of 30 adult patients diagnosed with ALD who were randomized into two groups of 15 each and were designated as group A (received standard treatment) and group B (received Vitamin E along with standard treatment). Quality of life was assessed by using Chronic Liver Disease Questionnaire (CLDQ) through its various domains along with global score, as a baseline measure before and after completing the treatment period of three months in each group and the scores were recorded and compared.

Result: In group A, scores in CLDQ-FA, CLDQ-AC domains and CLDQ-Global showed a statistically highly significant (P<0.001) improvement whereas in group B, there was a statistically highly significant change in all the domains of CLDQ along with CLDQ-Global score after the treatment duration. When the differences observed in various CLDQ scores in Group A were compared with those seen in Group B, the changes in CLDQ-Global score and CLDQ-SY domain score observed in Group B were highly significant (PV0.001) and also CLDQ-AB domain and CLDQ-FA domain in Group B were statistically significant (P<0.05) compared to their respective changes observed in Group A.

Conclusion: The result of this study suggests that supplementation of Vitamin E to standard treatment has significantly improved the Quality of Life in patients with ALD as evidenced by an improvement in the CLDQ scoring.

Key words: Chronic liver disease questionnaire (CLDQ); vitamin e; alcoholic liver disease; antioxidant


 
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Pubmed Style

Bhanu Prakash Kolasani, Prasanand Sasidharan, Divyashanthi C M, Adithiya Kumar. Vitamin E improves quality of life in patients with alcoholic liver disease. Natl J Physiol Pharm Pharmacol. 2016; 6(4): 269-275. doi:10.5455/njppp.2016.6.27012016125


Web Style

Bhanu Prakash Kolasani, Prasanand Sasidharan, Divyashanthi C M, Adithiya Kumar. Vitamin E improves quality of life in patients with alcoholic liver disease. https://www.njppp.com/?mno=216599 [Access: January 04, 2023]. doi:10.5455/njppp.2016.6.27012016125


AMA (American Medical Association) Style

Bhanu Prakash Kolasani, Prasanand Sasidharan, Divyashanthi C M, Adithiya Kumar. Vitamin E improves quality of life in patients with alcoholic liver disease. Natl J Physiol Pharm Pharmacol. 2016; 6(4): 269-275. doi:10.5455/njppp.2016.6.27012016125



Vancouver/ICMJE Style

Bhanu Prakash Kolasani, Prasanand Sasidharan, Divyashanthi C M, Adithiya Kumar. Vitamin E improves quality of life in patients with alcoholic liver disease. Natl J Physiol Pharm Pharmacol. (2016), [cited January 04, 2023]; 6(4): 269-275. doi:10.5455/njppp.2016.6.27012016125



Harvard Style

Bhanu Prakash Kolasani, Prasanand Sasidharan, Divyashanthi C M, Adithiya Kumar (2016) Vitamin E improves quality of life in patients with alcoholic liver disease. Natl J Physiol Pharm Pharmacol, 6 (4), 269-275. doi:10.5455/njppp.2016.6.27012016125



Turabian Style

Bhanu Prakash Kolasani, Prasanand Sasidharan, Divyashanthi C M, Adithiya Kumar. 2016. Vitamin E improves quality of life in patients with alcoholic liver disease. National Journal of Physiology, Pharmacy and Pharmacology, 6 (4), 269-275. doi:10.5455/njppp.2016.6.27012016125



Chicago Style

Bhanu Prakash Kolasani, Prasanand Sasidharan, Divyashanthi C M, Adithiya Kumar. "Vitamin E improves quality of life in patients with alcoholic liver disease." National Journal of Physiology, Pharmacy and Pharmacology 6 (2016), 269-275. doi:10.5455/njppp.2016.6.27012016125



MLA (The Modern Language Association) Style

Bhanu Prakash Kolasani, Prasanand Sasidharan, Divyashanthi C M, Adithiya Kumar. "Vitamin E improves quality of life in patients with alcoholic liver disease." National Journal of Physiology, Pharmacy and Pharmacology 6.4 (2016), 269-275. Print. doi:10.5455/njppp.2016.6.27012016125



APA (American Psychological Association) Style

Bhanu Prakash Kolasani, Prasanand Sasidharan, Divyashanthi C M, Adithiya Kumar (2016) Vitamin E improves quality of life in patients with alcoholic liver disease. National Journal of Physiology, Pharmacy and Pharmacology, 6 (4), 269-275. doi:10.5455/njppp.2016.6.27012016125