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Incidence of peptic ulcer in bronchial asthma and chronic obstructive pulmonary disease and its relation to Helicobacter pylori infection

Nesriene El-Margoushy, Ahmed M. A. Mansour, Nihad El-Nashar, Manal El-Nashar, Tamer Askar.

Abstract
Background: Asthma and chronic obstructive pulmonary disease (COPD) are characterized by a progressive airflow limitation. COPD is considered the fourth leading cause of death worldwide. Helicobacter pylori is a Gram-negative bacteria are closely associated with peptic ulcer development.

Aims and Objectives: This study aimed to compare the incidence of peptic ulcer disease between asthmatic and COPD group of patients and evaluation of its relation to H. pylori infection.

Materials and Methods: This study includes 50 patients with COPD from both sexes (M: 35/F:15), 50 patients with bronchial asthma from both sexes (M: 30/F: 20) from King Abdul-Aziz Hospital, Taif area, and 25 healthy control volunteers (M: 17/F: 8) matched in age and sex. Total immunoglobulin E (IgE), pH, pO2, pCO2, forced vital capacity (FVC), forced expiratory volume in first second (FEV1)/FVC, and forced expiratory flow (FEF) 25-75 were measured and matched between various groups.

Results: Total serum IgE T-IgE showed a non-significant increase in COPD patients compared to control (68.33 ± 16.74) while it increased significantly in asthmatic patients (243.65 ± 120.54) compared to control. Regarding pH, pO2, and pCO2 relation between control and asthmatic patients, the results are non-significant while it was significant (P < 0.05) for pH between control and COPD patients and was highly significant (P < 0.001) for pO2 and pCO2 in the two groups. For FVC, FEV1/FVC, and FEF 25-75 between control and asthma patients, results considered highly significant (P < 0.001) while it showed a significant difference (P < 0.05) for FEV1 in both groups. For FVC, FEV1/FVC, and FEF 25-75 between control and COPD patients, the results are considered highly significant (P < 0.001), and a very highly significant difference (P < 0.05) for control and COPD.

Conclusion: Close interaction between the incidence of peptic ulcer disease with asthma and COPD group of patients in relation to H. pylori infection was confirmed.

Key words: Peptic Ulcer; Chronic Obstructive Pulmonary Disease; Bronchial Asthma; Helicobacter pylori Infection


 
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How to Cite this Article
Pubmed Style

Nesriene El-Margoushy, Ahmed M. A. Mansour, Nihad El-Nashar, Manal El-Nashar, Tamer Askar. Incidence of peptic ulcer in bronchial asthma and chronic obstructive pulmonary disease and its relation to Helicobacter pylori infection. Natl J Physiol Pharm Pharmacol. 2016; 6(5): 376-380. doi:10.5455/njppp.2016.6.20160409224042016

Web Style

Nesriene El-Margoushy, Ahmed M. A. Mansour, Nihad El-Nashar, Manal El-Nashar, Tamer Askar. Incidence of peptic ulcer in bronchial asthma and chronic obstructive pulmonary disease and its relation to Helicobacter pylori infection. https://www.njppp.com/?mno=224840 [Access: February 01, 2023]. doi:10.5455/njppp.2016.6.20160409224042016

AMA (American Medical Association) Style

Nesriene El-Margoushy, Ahmed M. A. Mansour, Nihad El-Nashar, Manal El-Nashar, Tamer Askar. Incidence of peptic ulcer in bronchial asthma and chronic obstructive pulmonary disease and its relation to Helicobacter pylori infection. Natl J Physiol Pharm Pharmacol. 2016; 6(5): 376-380. doi:10.5455/njppp.2016.6.20160409224042016


Vancouver/ICMJE Style

Nesriene El-Margoushy, Ahmed M. A. Mansour, Nihad El-Nashar, Manal El-Nashar, Tamer Askar. Incidence of peptic ulcer in bronchial asthma and chronic obstructive pulmonary disease and its relation to Helicobacter pylori infection. Natl J Physiol Pharm Pharmacol. (2016), [cited February 01, 2023]; 6(5): 376-380. doi:10.5455/njppp.2016.6.20160409224042016


Harvard Style

Nesriene El-Margoushy, Ahmed M. A. Mansour, Nihad El-Nashar, Manal El-Nashar, Tamer Askar (2016) Incidence of peptic ulcer in bronchial asthma and chronic obstructive pulmonary disease and its relation to Helicobacter pylori infection. Natl J Physiol Pharm Pharmacol, 6 (5), 376-380. doi:10.5455/njppp.2016.6.20160409224042016


Turabian Style

Nesriene El-Margoushy, Ahmed M. A. Mansour, Nihad El-Nashar, Manal El-Nashar, Tamer Askar. 2016. Incidence of peptic ulcer in bronchial asthma and chronic obstructive pulmonary disease and its relation to Helicobacter pylori infection. National Journal of Physiology, Pharmacy and Pharmacology, 6 (5), 376-380. doi:10.5455/njppp.2016.6.20160409224042016


Chicago Style

Nesriene El-Margoushy, Ahmed M. A. Mansour, Nihad El-Nashar, Manal El-Nashar, Tamer Askar. "Incidence of peptic ulcer in bronchial asthma and chronic obstructive pulmonary disease and its relation to Helicobacter pylori infection." National Journal of Physiology, Pharmacy and Pharmacology 6 (2016), 376-380. doi:10.5455/njppp.2016.6.20160409224042016


MLA (The Modern Language Association) Style

Nesriene El-Margoushy, Ahmed M. A. Mansour, Nihad El-Nashar, Manal El-Nashar, Tamer Askar. "Incidence of peptic ulcer in bronchial asthma and chronic obstructive pulmonary disease and its relation to Helicobacter pylori infection." National Journal of Physiology, Pharmacy and Pharmacology 6.5 (2016), 376-380. Print. doi:10.5455/njppp.2016.6.20160409224042016


APA (American Psychological Association) Style

Nesriene El-Margoushy, Ahmed M. A. Mansour, Nihad El-Nashar, Manal El-Nashar, Tamer Askar (2016) Incidence of peptic ulcer in bronchial asthma and chronic obstructive pulmonary disease and its relation to Helicobacter pylori infection. National Journal of Physiology, Pharmacy and Pharmacology, 6 (5), 376-380. doi:10.5455/njppp.2016.6.20160409224042016


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