Time domain measures of heart rate variability during acute mental stress in Type 2 diabetics- A case control study

Anupama Deepak; Deepak A N; Shobha Nallulwar; Vitthal Khode

doi:10.5455/njppp.2014.4.080720131

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Online Published: 08 Jul 2013

Natl J Physiol Pharm Pharmacol. 2014; 4(1): 34-38

doi: 10.5455/njppp.2014.4.080720131

Time domain measures of heart rate variability during acute mental stress in Type 2 diabetics- A case control study

Anupama Deepak, Deepak A N, Shobha Nallulwar, Vitthal Khode.

Cited By:14

Abstract
Background: Cardiovascular Autonomic Diabetic Neuropathy (CADN) is one of the most important diabetes- associated complications. Reduced heart rate variation (HRV) is the earliest indicator of CADN. The prospect of using time domain analysis of HRV using mental arithmetic as a stressor has for early diagnosis of CADN has not been studied so far.

Aims & Objective: To compare time domain parameters of HRV at rest and during acute mental stress between Type 2 diabetics and non- diabetics.

Materials and Methods: 30 male asymptomatic, Type 2 diabetics with duration of diabetes of 2-8 yrs with RBS ≥ 200 mg/dl or FBS ≥ 126 mg/dl in the age group of 30-65 yrs were chosen as subjects. 30 age and sex matched healthy non-diabetics were chosen as controls. HRV analysis was done using ECG recorded at rest in supine position for 5 min and during 5 min of acute mental stress testing.

Results: At rest standard deviation of all R-R intervals (SDNN), root mean square of successive RR- interval differences (RMSSD), number of intervals differing by > 50ms from adjacent interval (NN50) and percentage of NN50 (pNN50) were significantly less in diabetics as compared to non- diabetics. Mental stress showed increases in HR, SBP and DBP in non-diabetics as well as diabetics but SDNN was significantly less in diabetics as compared to non- diabetics during stress.

Conclusion: Data from the study demonstrated that diabetics with 8-10 yrs history had already developed parasympathetic autonomic neuropathy. Time domain analysis of HRV during mental stress can be used as a valuable tool for early diagnosis of autonomic neuropathy to prevent further complications.

Key words: Heart rate variability, Time Domain Analysis, Cardiovascular Diabetic Autonomic Neuropathy

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Pubmed Style

Deepak A, N DA, Nallulwar S, Khode V. Time domain measures of heart rate variability during acute mental stress in Type 2 diabetics- A case control study. Natl J Physiol Pharm Pharmacol. 2014; 4(1): 34-38. doi:10.5455/njppp.2014.4.080720131

Web Style

Deepak A, N DA, Nallulwar S, Khode V. Time domain measures of heart rate variability during acute mental stress in Type 2 diabetics- A case control study. https://www.njppp.com/?mno=40570 [Access: June 26, 2026]. doi:10.5455/njppp.2014.4.080720131

AMA (American Medical Association) Style

Deepak A, N DA, Nallulwar S, Khode V. Time domain measures of heart rate variability during acute mental stress in Type 2 diabetics- A case control study. Natl J Physiol Pharm Pharmacol. 2014; 4(1): 34-38. doi:10.5455/njppp.2014.4.080720131

Vancouver/ICMJE Style

Deepak A, N DA, Nallulwar S, Khode V. Time domain measures of heart rate variability during acute mental stress in Type 2 diabetics- A case control study. Natl J Physiol Pharm Pharmacol. (2014), [cited June 26, 2026]; 4(1): 34-38. doi:10.5455/njppp.2014.4.080720131

Harvard Style

Deepak, A., N, . D. A., Nallulwar, . S. & Khode, . V. (2014) Time domain measures of heart rate variability during acute mental stress in Type 2 diabetics- A case control study. Natl J Physiol Pharm Pharmacol, 4 (1), 34-38. doi:10.5455/njppp.2014.4.080720131

Turabian Style

Deepak, Anupama, Deepak A N, Shobha Nallulwar, and Vitthal Khode. 2014. Time domain measures of heart rate variability during acute mental stress in Type 2 diabetics- A case control study. National Journal of Physiology, Pharmacy and Pharmacology, 4 (1), 34-38. doi:10.5455/njppp.2014.4.080720131

Chicago Style

Deepak, Anupama, Deepak A N, Shobha Nallulwar, and Vitthal Khode. "Time domain measures of heart rate variability during acute mental stress in Type 2 diabetics- A case control study." National Journal of Physiology, Pharmacy and Pharmacology 4 (2014), 34-38. doi:10.5455/njppp.2014.4.080720131

MLA (The Modern Language Association) Style

APA (American Psychological Association) Style

Deepak, A., N, . D. A., Nallulwar, . S. & Khode, . V. (2014) Time domain measures of heart rate variability during acute mental stress in Type 2 diabetics- A case control study. National Journal of Physiology, Pharmacy and Pharmacology, 4 (1), 34-38. doi:10.5455/njppp.2014.4.080720131

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