E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research 


Effects of soy isoflavone genistein on lipid profile and hepatic steatosis in high-fat-fed Wistar rats

Deepa Kameswari Perumal, Mangaiarkkarasi Adhimoolam, Erli Amel Ivan, Meher Ali Rajamohammed.

Abstract
Background: Hyperlipidemia is a major cause of atherosclerosis-induced conditions such as coronary heart disease, ischemic cerebrovascular disease, and peripheral vascular disease. Due to various adverse effects with the current pharmacological therapy, many plant-derived compounds are being tested to lower serum lipid levels. Genistein, a soy isoflavone, showed promising results in several studies.

Aims and Objectives: The study aimed to evaluate the effectiveness of genistein on serum lipid profile and its hepatoprotective activity in hyperlipidemic male albino Wistar rats.

Materials and Methods: Thirty-six male Wistar rats were randomly divided into six groups. Animals were given high cholesterol diet (0.75% cholesterol + 1.5% bile salt) to induce hyperlipidemia. The animals were treated with atorvastatin (10 mg/kg oral) and genistein (1 mg/kg oral and 5 mg/kg oral) once daily for a period of 30 days. Blood samples were collected for biochemical analysis of lipoproteins and a portion of liver tissue was taken for histopathological examination. Statistical analysis was performed by one-way analysis of variance test followed by post hoc DunnettÂ’s multiple comparison test. P < 0.05 was considered statistically significant.

Results: Oral administration of genistein showed a significant reduction in serum total cholesterol, triglycerides, and low-density lipoprotein levels. Histopathological examination of liver showed a significant reduction in hepatic steatosis (P < 0.001) with no inflammatory changes as compared to high cholesterol-treated rats.

Conclusion: The present study demonstrated significant hypolipidemic and hepatoprotective activities of genistein at a dose of 5 mg/kg in the experimental rats.

Key words: Genistein; Hypolipidemia; Hepatic Steatosis; High-fat Diet


 
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How to Cite this Article
Pubmed Style

Perumal DK, Adhimoolam M, Ivan EA, Rajamohammed MA. Effects of soy isoflavone genistein on lipid profile and hepatic steatosis in high-fat-fed Wistar rats. Natl J Physiol Pharm Pharmacol. 2019; 9(9): 856-861. doi:10.5455/njppp.2019.9.0621617062019


Web Style

Perumal DK, Adhimoolam M, Ivan EA, Rajamohammed MA. Effects of soy isoflavone genistein on lipid profile and hepatic steatosis in high-fat-fed Wistar rats. https://www.njppp.com/?mno=52499 [Access: December 01, 2022]. doi:10.5455/njppp.2019.9.0621617062019


AMA (American Medical Association) Style

Perumal DK, Adhimoolam M, Ivan EA, Rajamohammed MA. Effects of soy isoflavone genistein on lipid profile and hepatic steatosis in high-fat-fed Wistar rats. Natl J Physiol Pharm Pharmacol. 2019; 9(9): 856-861. doi:10.5455/njppp.2019.9.0621617062019



Vancouver/ICMJE Style

Perumal DK, Adhimoolam M, Ivan EA, Rajamohammed MA. Effects of soy isoflavone genistein on lipid profile and hepatic steatosis in high-fat-fed Wistar rats. Natl J Physiol Pharm Pharmacol. (2019), [cited December 01, 2022]; 9(9): 856-861. doi:10.5455/njppp.2019.9.0621617062019



Harvard Style

Perumal, D. K., Adhimoolam, . M., Ivan, . E. A. & Rajamohammed, . M. A. (2019) Effects of soy isoflavone genistein on lipid profile and hepatic steatosis in high-fat-fed Wistar rats. Natl J Physiol Pharm Pharmacol, 9 (9), 856-861. doi:10.5455/njppp.2019.9.0621617062019



Turabian Style

Perumal, Deepa Kameswari, Mangaiarkkarasi Adhimoolam, Erli Amel Ivan, and Meher Ali Rajamohammed. 2019. Effects of soy isoflavone genistein on lipid profile and hepatic steatosis in high-fat-fed Wistar rats. National Journal of Physiology, Pharmacy and Pharmacology, 9 (9), 856-861. doi:10.5455/njppp.2019.9.0621617062019



Chicago Style

Perumal, Deepa Kameswari, Mangaiarkkarasi Adhimoolam, Erli Amel Ivan, and Meher Ali Rajamohammed. "Effects of soy isoflavone genistein on lipid profile and hepatic steatosis in high-fat-fed Wistar rats." National Journal of Physiology, Pharmacy and Pharmacology 9 (2019), 856-861. doi:10.5455/njppp.2019.9.0621617062019



MLA (The Modern Language Association) Style

Perumal, Deepa Kameswari, Mangaiarkkarasi Adhimoolam, Erli Amel Ivan, and Meher Ali Rajamohammed. "Effects of soy isoflavone genistein on lipid profile and hepatic steatosis in high-fat-fed Wistar rats." National Journal of Physiology, Pharmacy and Pharmacology 9.9 (2019), 856-861. Print. doi:10.5455/njppp.2019.9.0621617062019



APA (American Psychological Association) Style

Perumal, D. K., Adhimoolam, . M., Ivan, . E. A. & Rajamohammed, . M. A. (2019) Effects of soy isoflavone genistein on lipid profile and hepatic steatosis in high-fat-fed Wistar rats. National Journal of Physiology, Pharmacy and Pharmacology, 9 (9), 856-861. doi:10.5455/njppp.2019.9.0621617062019