E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research 


A cross-sectional study of serum level of malondialdehyde in type 2 diabetes mellitus individuals of rural population of North Karnataka

Amar Arun Barawade, Sanjay Bhalerao, Shivprasad Goudar.

Abstract
Background: Oxidative stress is not only involved in the pathogenesis of many chronic diseases like diabetes mellitus (DM) but also in various physiological processes like aging. In this process, highly reactive free radicals are formed. These free radicals react with lipids and carry out lipid peroxidation, which result in the formation of aldehyde products like malondialdehyde (MDA). The serum level of MDA can serve as an important indicator of oxidative stress. This study helps to assess differences in MDA level as a biomarker of oxidative stress in healthy and type 2 DM (T2DM) patients.

Aims and Objectives: This study aims to investigate the serum MDA level in T2DM patients and its association with other risk factors such as obesity, diet, and duration of diabetes in T2DM patients.

Materials and Methods: The present cross-sectional study was conducted in 93 T2DM patients and 93 healthy individuals. Serum levels of MDA are the most commonly used markers of this process which was measured as thiobarbituric acid reactive substances (TBARS). The MDA-TBA adduct so formed has a colorimetric measurement at 532 nm on spectrophotometer.

Results: The MDA concentrations of healthy controls and T2DM patients were 0.931 and 2.684 ╬╝mol/l, respectively. The serum MDA concentration in T2DM patients was significantly elevated (P < 0.001) compared with healthy individuals. MDA levels were significantly correlated (P < 0.001) with conventional risk factors such as diet, truncal obesity, and duration of diabetes in T2DM patients.

Conclusion: Serum level of MDA was significantly increased in T2DM patients. It may be a good marker of oxidative stress that is involved in various complications of T2DM. Elevated MDA levels are also associated with conventional risk factors such as diet, truncal obesity, and duration of diabetes.

Key words: Lipid Peroxidation; Malondialdehyde; Oxidative Stress; Type 2 Diabetes Mellitus


 
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How to Cite this Article
Pubmed Style

Barawade AA, Bhalerao S, Goudar S. A cross-sectional study of serum level of malondialdehyde in type 2 diabetes mellitus individuals of rural population of North Karnataka. Natl J Physiol Pharm Pharmacol. 2019; 9(9): 934-939. doi:10.5455/njppp.2019.9.0724517072019


Web Style

Barawade AA, Bhalerao S, Goudar S. A cross-sectional study of serum level of malondialdehyde in type 2 diabetes mellitus individuals of rural population of North Karnataka. https://www.njppp.com/?mno=55434 [Access: December 01, 2022]. doi:10.5455/njppp.2019.9.0724517072019


AMA (American Medical Association) Style

Barawade AA, Bhalerao S, Goudar S. A cross-sectional study of serum level of malondialdehyde in type 2 diabetes mellitus individuals of rural population of North Karnataka. Natl J Physiol Pharm Pharmacol. 2019; 9(9): 934-939. doi:10.5455/njppp.2019.9.0724517072019



Vancouver/ICMJE Style

Barawade AA, Bhalerao S, Goudar S. A cross-sectional study of serum level of malondialdehyde in type 2 diabetes mellitus individuals of rural population of North Karnataka. Natl J Physiol Pharm Pharmacol. (2019), [cited December 01, 2022]; 9(9): 934-939. doi:10.5455/njppp.2019.9.0724517072019



Harvard Style

Barawade, A. A., Bhalerao, . S. & Goudar, . S. (2019) A cross-sectional study of serum level of malondialdehyde in type 2 diabetes mellitus individuals of rural population of North Karnataka. Natl J Physiol Pharm Pharmacol, 9 (9), 934-939. doi:10.5455/njppp.2019.9.0724517072019



Turabian Style

Barawade, Amar Arun, Sanjay Bhalerao, and Shivprasad Goudar. 2019. A cross-sectional study of serum level of malondialdehyde in type 2 diabetes mellitus individuals of rural population of North Karnataka. National Journal of Physiology, Pharmacy and Pharmacology, 9 (9), 934-939. doi:10.5455/njppp.2019.9.0724517072019



Chicago Style

Barawade, Amar Arun, Sanjay Bhalerao, and Shivprasad Goudar. "A cross-sectional study of serum level of malondialdehyde in type 2 diabetes mellitus individuals of rural population of North Karnataka." National Journal of Physiology, Pharmacy and Pharmacology 9 (2019), 934-939. doi:10.5455/njppp.2019.9.0724517072019



MLA (The Modern Language Association) Style

Barawade, Amar Arun, Sanjay Bhalerao, and Shivprasad Goudar. "A cross-sectional study of serum level of malondialdehyde in type 2 diabetes mellitus individuals of rural population of North Karnataka." National Journal of Physiology, Pharmacy and Pharmacology 9.9 (2019), 934-939. Print. doi:10.5455/njppp.2019.9.0724517072019



APA (American Psychological Association) Style

Barawade, A. A., Bhalerao, . S. & Goudar, . S. (2019) A cross-sectional study of serum level of malondialdehyde in type 2 diabetes mellitus individuals of rural population of North Karnataka. National Journal of Physiology, Pharmacy and Pharmacology, 9 (9), 934-939. doi:10.5455/njppp.2019.9.0724517072019