A randomized open-label study to compare the effects of amlodipine and cilnidipine on heart rate and proteinuria in subjects with hypertension with proteinuria

Ajay D Shanbhag; Hema Narasimhe Gowda; Laxmegowda

doi:10.5455/njppp.2018.8.0723228072018

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Original Research
Online Published: 08 Aug 2018

Natl J Physiol Pharm Pharmacol. 2018; 8(11): 1485-1490

doi: 10.5455/njppp.2018.8.0723228072018

A randomized open-label study to compare the effects of amlodipine and cilnidipine on heart rate and proteinuria in subjects with hypertension with proteinuria

Ajay D Shanbhag, Hema Narasimhe Gowda, Laxmegowda.

Cited By:5

Abstract
Background: Calcium channel blockers (CCBs) are a commonly used class of drugs for the treatment of hypertension. Cilnidipine is a novel CCB with a dual L/N-type CCB property, thus favoring additional renal and cardiovascular protection.

Aims and Objectives: The aims of this study were to evaluate the effects and their linearity across the time frame of amlodipine and cilnidipine in hypertensive subjects with proteinuria on heart rate and proteinuria.

Materials and Methods: A prospective, randomized, open-label study was carried out on hypertensive subjects with proteinuria attending the General Medicine OPD in K.R Hospital, Mysore. 60 subjects satisfying the inclusion and exclusion criteria were included in the study. Heart rate and urine protein-to-creatinine ratio (UPCR) were measured at baseline and at 12 weeks along with weekly heart rate monitoring. The dose of amlodipine and cilnidipine was titrated depending on the blood pressure control. Descriptive statistics, independent sample t-test, repeated measure ANOVA, and Cramers V-test were used to analyze the results.

Results: Demographic profile was well matched in both the groups. The heart rate was significantly higher at 12 weeks in subjects treated with amlodipine, while subjects in the cilnidipine group showed a significantly higher heart rate compared to baseline (P < 0.05). Furthermore, while the UPCR was significantly decreased in the cilnidipine group, a significant increase was seen in the amlodipine group, thereby resulting in a significant intergroup difference (P < 0.05).

Conclusion: Cilnidipine is, thus, a better alternative in hypertensive patients with proteinuria due to its cardioprotective and renoprotective actions.

Key words: Proteinuria; Heart Rate; Amlodipine; Cilnidipine

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Pubmed Style

Shanbhag AD, Gowda HN, Laxmegowda . A randomized open-label study to compare the effects of amlodipine and cilnidipine on heart rate and proteinuria in subjects with hypertension with proteinuria. Natl J Physiol Pharm Pharmacol. 2018; 8(11): 1485-1490.

doi:10.5455/njppp.2018.8.0723228072018

Web Style

Shanbhag AD, Gowda HN, Laxmegowda . A randomized open-label study to compare the effects of amlodipine and cilnidipine on heart rate and proteinuria in subjects with hypertension with proteinuria. https://www.njppp.com/?mno=1137 [Access: June 27, 2026].

doi:10.5455/njppp.2018.8.0723228072018

AMA (American Medical Association) Style

Shanbhag AD, Gowda HN, Laxmegowda . A randomized open-label study to compare the effects of amlodipine and cilnidipine on heart rate and proteinuria in subjects with hypertension with proteinuria. Natl J Physiol Pharm Pharmacol. 2018; 8(11): 1485-1490.

doi:10.5455/njppp.2018.8.0723228072018

Vancouver/ICMJE Style

Shanbhag AD, Gowda HN, Laxmegowda . A randomized open-label study to compare the effects of amlodipine and cilnidipine on heart rate and proteinuria in subjects with hypertension with proteinuria. Natl J Physiol Pharm Pharmacol. (2018), [cited June 27, 2026]; 8(11): 1485-1490.

doi:10.5455/njppp.2018.8.0723228072018

Harvard Style

Shanbhag, A. D., Gowda, . H. N. & Laxmegowda, . (2018) A randomized open-label study to compare the effects of amlodipine and cilnidipine on heart rate and proteinuria in subjects with hypertension with proteinuria. Natl J Physiol Pharm Pharmacol, 8 (11), 1485-1490.

doi:10.5455/njppp.2018.8.0723228072018

Turabian Style

Shanbhag, Ajay D, Hema Narasimhe Gowda, and Laxmegowda. 2018. A randomized open-label study to compare the effects of amlodipine and cilnidipine on heart rate and proteinuria in subjects with hypertension with proteinuria. National Journal of Physiology, Pharmacy and Pharmacology, 8 (11), 1485-1490.

doi:10.5455/njppp.2018.8.0723228072018

Chicago Style

Shanbhag, Ajay D, Hema Narasimhe Gowda, and Laxmegowda. "A randomized open-label study to compare the effects of amlodipine and cilnidipine on heart rate and proteinuria in subjects with hypertension with proteinuria." National Journal of Physiology, Pharmacy and Pharmacology 8 (2018), 1485-1490.

doi:10.5455/njppp.2018.8.0723228072018

MLA (The Modern Language Association) Style

doi:10.5455/njppp.2018.8.0723228072018

APA (American Psychological Association) Style

doi:10.5455/njppp.2018.8.0723228072018

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