E-ISSN 2231-3206 | ISSN 2320-4672
 

Original Research 


A study to evaluate the pattern, causality, predictability, and severity of adverse drug reactions to corticosteroid therapy in pediatric idiopathic nephrotic syndrome at a tertiary care center

Nandini H C, Sushma Muraraiah, Anil Kumar.

Abstract
Background: Adverse drug reactions (ADRs) in children cannot be predicted based on those observed in adults. Systematic surveillance of ADRs in children, in particular to corticosteroids are limited.

Aim and Objective: The aim of the study was to evaluate the pattern as well as causality, preventability, and severity of occurrence of ADRs due to corticosteroid therapy in pediatric idiopathic nephrotic syndrome (INS).

Materials and Methods: After obtaining approval from Institutional Ethics Committee and informed consent/assent, 98 patients who developed ADRs were included in the study. Each patient’s demographic, clinical, treatment data, response pattern, and ADRs to corticosteroids as per Indian Academy of Pediatrics guidelines were noted in the pro forma. The data were analyzed using descriptive statistics.

Results: Total of 148 ADRs were observed due to corticosteroids among 98 patients diagnosed with nephrotic syndrome. The most common ADR was cushingoid features (18%), followed by infections (14%), gastrointestinal symptoms (11.48%), hypocalcemia (8%), and growth retardation (7%). About 45% of the ADRs were of “possible” causality and 32% were certain. Severity assessment indicates 54% as mild and majority of ADRs were not preventable.

Conclusions: This study provides data of ADRs to corticosteroid therapy in INS patients. Most of the ADRs were predictable and possibly preventable and mild, which highlights the importance of early detection and management of ADR.

Key words: Idiopathic Nephrotic Syndrome; Adverse Drug Reactions; Corticosteroids


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Nandini H C
Articles by Sushma Muraraiah
Articles by Anil Kumar
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

C NH, Muraraiah S, Kumar A. A study to evaluate the pattern, causality, predictability, and severity of adverse drug reactions to corticosteroid therapy in pediatric idiopathic nephrotic syndrome at a tertiary care center. Natl J Physiol Pharm Pharmacol. 2022; 12(10): 1583-1587. doi:10.5455/njppp.2022.12.10372202103022022


Web Style

C NH, Muraraiah S, Kumar A. A study to evaluate the pattern, causality, predictability, and severity of adverse drug reactions to corticosteroid therapy in pediatric idiopathic nephrotic syndrome at a tertiary care center. https://www.njppp.com/?mno=131876 [Access: December 01, 2022]. doi:10.5455/njppp.2022.12.10372202103022022


AMA (American Medical Association) Style

C NH, Muraraiah S, Kumar A. A study to evaluate the pattern, causality, predictability, and severity of adverse drug reactions to corticosteroid therapy in pediatric idiopathic nephrotic syndrome at a tertiary care center. Natl J Physiol Pharm Pharmacol. 2022; 12(10): 1583-1587. doi:10.5455/njppp.2022.12.10372202103022022



Vancouver/ICMJE Style

C NH, Muraraiah S, Kumar A. A study to evaluate the pattern, causality, predictability, and severity of adverse drug reactions to corticosteroid therapy in pediatric idiopathic nephrotic syndrome at a tertiary care center. Natl J Physiol Pharm Pharmacol. (2022), [cited December 01, 2022]; 12(10): 1583-1587. doi:10.5455/njppp.2022.12.10372202103022022



Harvard Style

C, N. H., Muraraiah, . S. & Kumar, . A. (2022) A study to evaluate the pattern, causality, predictability, and severity of adverse drug reactions to corticosteroid therapy in pediatric idiopathic nephrotic syndrome at a tertiary care center. Natl J Physiol Pharm Pharmacol, 12 (10), 1583-1587. doi:10.5455/njppp.2022.12.10372202103022022



Turabian Style

C, Nandini H, Sushma Muraraiah, and Anil Kumar. 2022. A study to evaluate the pattern, causality, predictability, and severity of adverse drug reactions to corticosteroid therapy in pediatric idiopathic nephrotic syndrome at a tertiary care center. National Journal of Physiology, Pharmacy and Pharmacology, 12 (10), 1583-1587. doi:10.5455/njppp.2022.12.10372202103022022



Chicago Style

C, Nandini H, Sushma Muraraiah, and Anil Kumar. "A study to evaluate the pattern, causality, predictability, and severity of adverse drug reactions to corticosteroid therapy in pediatric idiopathic nephrotic syndrome at a tertiary care center." National Journal of Physiology, Pharmacy and Pharmacology 12 (2022), 1583-1587. doi:10.5455/njppp.2022.12.10372202103022022



MLA (The Modern Language Association) Style

C, Nandini H, Sushma Muraraiah, and Anil Kumar. "A study to evaluate the pattern, causality, predictability, and severity of adverse drug reactions to corticosteroid therapy in pediatric idiopathic nephrotic syndrome at a tertiary care center." National Journal of Physiology, Pharmacy and Pharmacology 12.10 (2022), 1583-1587. Print. doi:10.5455/njppp.2022.12.10372202103022022



APA (American Psychological Association) Style

C, N. H., Muraraiah, . S. & Kumar, . A. (2022) A study to evaluate the pattern, causality, predictability, and severity of adverse drug reactions to corticosteroid therapy in pediatric idiopathic nephrotic syndrome at a tertiary care center. National Journal of Physiology, Pharmacy and Pharmacology, 12 (10), 1583-1587. doi:10.5455/njppp.2022.12.10372202103022022